The role of fibrin glue instillation under skin flaps in the prevention of seroma formation and related morbidities following breast and axillary surgery for breast cancer: A meta‐analysis

Sajid, M. S.; Hutson, Kristian; Kalra, L.; Bonomi, Riccardo

doi:10.1002/jso.23140

Cited by 23 publications

(15 citation statements)

References 54 publications

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“…Another reported off‐label application of bioadhesives is to prevent seroma, which is a common postsurgical complication. Interruption of lymphatic system and vasculatures during surgery causes drainage and accumulation of serous fluids in the space created by surgery 92, 93. If not treated, seroma can cause massive complications 92.…”

Section: Applications Of Bioadhesives In Tissue Engineeringmentioning

confidence: 99%

Design Strategies and Applications of Tissue Bioadhesives

Mehdizadeh

Yang

2012

Macromolecular Bioscience

372

377

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In the past two decades tissue adhesives and sealants have revolutionized hemostasis and wound management in traumatic and surgical injuries. Various biological-driven glues and synthetic adhesives are clinically utilized either as an adjunct to conventional hemostats and wound closure techniques, such as suturing, or as a replacement to them. The ability to effectively and promptly control bleeding, thus, reducing the risk of complications due to severe blood loss, in addition to convenience of use render medical adhesive a highly suitable tool for wound management. This review focuses on existing tissue adhesive systems, their structure, functioning mechanism, indicated and off-label applications, and limitations. It also includes the latest advances in the development of new tissue adhesives as well as the emerging applications in regenerative medicine. We expect that this review will provide insightful discussion on tissue bioadhesive design and lead to innovations for the development of the next generation of tissue bioadhesives and their related biomedical applications.

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Section: Applications Of Bioadhesives In Tissue Engineeringmentioning

confidence: 99%

Design Strategies and Applications of Tissue Bioadhesives

Mehdizadeh

Yang

2012

Macromolecular Bioscience

372

377

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“…A prospective, randomized, single center report [188] performed over one year as well as a separate meta-analysis [189] found a lack of success using fibrin sealant to reduce serous drainage following mastectomy. The first [188] found trends, but no statistically significant benefit of using fibrin sealant ( n = 31) as compared to control ( n = 29) to reduce seroma formation (16.1% versus 24.1%, P = 0.43).…”

Section: Most Frequent Fibrin Sealant Clinical Literature Applicatmentioning

confidence: 99%

“…This method may have allowed the more slowly polymerizing fibrin sealant to run off to the more dependent portions of the wound before polymerizing resulting in an uneven seal. The meta-analysis [189] suggested that thus far fibrin sealant has failed to prove a benefit in terms of postoperative seroma formation, average seroma volume, wound infection, complications, and length of stay. The authors recommended a new, controlled, large, multicenter, prospective, randomized, clinical trial to resolve this issue.…”

Section: Most Frequent Fibrin Sealant Clinical Literature Applicatmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current fibrin sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of fibrin sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin sealant remains useful hemostat, sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin sealant has multiple new uses that should result in further improvements in patient care.

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“…3 articles investigated the impact of different instruments/fibrin glue on seroma production [16,17,18]. Other authors published on primary breast infections occurring without breast surgery or on breast wound dressing [19,20].…”

Section: Resultsmentioning

confidence: 99%

Should a Drain Be Placed in Early Breast Cancer Surgery?

et al. 2014

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Background: The current surgical debate has led to a reduction in the extent of surgery performed and thereby to a reduced occurrence of surgical trauma and, over the recent years, reduced seroma formation. This reduction in surgical procedures calls the need for a drain into question. Method: Using Google Scholar and the National Library of Medicine (PubMed), a literature review was performed on systematic reviews and meta-analyses regarding breast cancer surgery ± axillary dissection. Additionally, randomized trials for the time period after the last systematic review were included and evaluated according to the Jadad score. Results: The search returned 5 systematic reviews, in which a total of 1,075 patients were included (537 cases and 538 controls). Since the last review, no prospective randomized trial meeting the inclusion criteria has been published. The current reviews conclude that insertion of a drain is associated with a longer hospital stay and reduced seroma formation. The data regarding wound infection and drain insertion is inconclusive. The omission of a drain is associated with early discharge, reduced postsurgical pain, and early mobilization, but also with an increase in out-patient seroma aspirations. Conclusion: The omission of a drain is possible in early breast cancer surgery (wide local excision and sentinel node biopsy) with adequate surgical techniques and instruments.

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The role of fibrin glue instillation under skin flaps in the prevention of seroma formation and related morbidities following breast and axillary surgery for breast cancer: A meta‐analysis

Cited by 23 publications

References 54 publications

Design Strategies and Applications of Tissue Bioadhesives

Design Strategies and Applications of Tissue Bioadhesives

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Should a Drain Be Placed in Early Breast Cancer Surgery?

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