The Role of Fe3+ on Fe2+-Dependent Lipid Peroxidation in Phospholipid Liposomes.

Abstract

Lipid peroxidation in cell membrane phospholipids induced by reactive oxygen species (ROS) and/or free radicals leads to membrane damage and has been proposed to be a major mechanism for the onset of several pathological events in vivo including postischemic-reperfusion injury, cancer, Parkinson's disease, senile dementia and aging.

Effects of Different Phases of Cigarette Smoke on Lipid Peroxidation and Membrane Structure in Liposomes

“…Liposomes were incubated at 378C in closed tubes for different periods of time to study either FeSO 4 -initiated [47] ( [FeSO 4 ] ¼ 100 mM) or spontaneous LPO. At different times, aliquots of each suspension were withdrawn to evaluate the content of the DC and ketodienes (KD).…”

In vitro effect of aluminium upon erythrocyte membrane properties

“…It's known that Fe(II) facilitate the initiation and/or propagation of lipid peroxidation by increasing the rate of Fe(II)-generated reactive oxygen species [6,30,37]. Studies performed on liposome had reported that Al(III) -a metal without redox capacity -enhances Fe(II)-induced lipid peroxidation and causes membrane rigidification [45].…”

“…The hypothesis proposes that Al(III) can stimulate Fe(II)-initiated lipid peroxidation by increasing lipid packing and by promoting the formation of rigid clusters. Both processes will bring phospholipids acyl chain closer together, thus favouring the propagation step of lipid peroxidation [30,44] and membrane damage. Since RBC posses high iron quantities, the observed changes in the physical properties of RBC membranes could be due to this Al(III) ability.…”

Stabilization of Plasmid DNA and Lipid-Based Therapeutics as Dehydrated Formulations

“…Despite this great progress, prolonged storage of lipoplexes in aqueous formulation yet is difficult to achieve considering the high sensitivity of both DNA and lipid components to hydrolytic and oxidative degradation [61,66,67,79,[271][272][273]. Furthermore, it has been reported that DNA functionality and structure may be damaged directly by co-oxidation with lipids [274][275][276].…”