The role of external anti-inflammatory therapy of dermatoses in children

Шарова, Н. М.

doi:10.21518/2079-701x-2018-17-177-180

Med. sov.

2018

DOI: 10.21518/2079-701x-2018-17-177-180

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The role of external anti-inflammatory therapy of dermatoses in children

Н. М. Шарова

Abstract: The article deals with the clinical aspects of inflammatory manifestations of dermatoses at an early age. It presents the results of the use of a non-steroidal anti-inflammatory drug based on activated pyrithione zinc

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2022

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The efficacy of activated zinc pyrithione in the treatment of IgE-independent atopic dermatitis in children

et al. 2022

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Introduction. Colonization of the skin with S. aureus and S. epidermidis in children with atopic dermatitis leads to the initiation of inflammation and worsening of the disease. The control of overcolonization with S. aureus is an important issue in pediatric dermatological practice. At the same time, to achieve a controlled level of colonization, it is preferable to prescribe non-steroidal external agents. Activated zinc pyrithione has a wide range of complementary pharmacodynamic effects, including anti-inflammatory, pro-apoptogenic, antimicrobial, and antifungal. The article presents the results of the use of zinc pyrithione in mild IgE-independent atopic dermatitis in children. The results of the main clinical studies confirming the effect of zinc pyrithione on the microbiome in AD and the severity of the disease were analyzed.Aim. To evaluate the therapeutic and microbiological efficacy of activated zinc pyrithione as monotherapy in patients with IgEindependent atopic dermatitis.Materials and methods. 30 patients aged 2 to 8 years with mild atopic dermatitis in the acute stage were divided into 2 groups. Group 1 received activated zinc pyrithione, group 2 received a combined topical steroid.Results. Both groups showed a significant reduction in S. aureus skin colonization. In both groups, in comparison with the initial state, a significant decrease in the severity of clinical manifestations of AD was obtained. The therapeutic efficacy of zinc pyrithione was 93.3%, clinical remission was observed in 73.3% of cases.Conclusion. The totality of currently available data on the clinical efficacy and safety of activated zinc pyrithione allows us to recommend it as one of the effective agents for external therapy of mild IgE-independent atopic dermatitis. The use of activated zinc pyrithione showed a rapid, pronounced positive result of treatment, a decrease in the risk of secondary infection in observed children with IgE-independent atopic dermatitis.

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The efficacy of activated zinc pyrithione in the treatment of IgE-independent atopic dermatitis in children

et al. 2022

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The role of external anti-inflammatory therapy of dermatoses in children

Abstract: The article deals with the clinical aspects of inflammatory manifestations of dermatoses at an early age. It presents the results of the use of a non-steroidal anti-inflammatory drug based on activated pyrithione zinc

Cited by 1 publication

References 6 publications

The efficacy of activated zinc pyrithione in the treatment of IgE-independent atopic dermatitis in children

The efficacy of activated zinc pyrithione in the treatment of IgE-independent atopic dermatitis in children

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