The role of exogenous Fibrinogen in cardiac surgery: stop bleeding or induce cardiovascular disease

Javaherforooshzadeh, Fatemeh; Mohammadtaghizadeh, Mohammadjavad; Bahadori, Hojatolah; Saki, Najmaldin; Rezaeeyan, Hadi

doi:10.1007/s11033-020-05880-y

Cited by 13 publications

(5 citation statements)

References 82 publications

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“…[51][52][53][54] Based on these, FAK signaling is also recognized as a therapeutic target for atherogenesis and cardiovascular diseases. [55][56][57] However, evidence of the direct relation among FAK, MMP-9, and AMI is still unavailable, which needs further study. Same as MMP-9, S100 is also one of the biomarkers of AMI as same as MMP-9.…”

Section: Discussionmentioning

confidence: 99%

Identification of Immuno-Inflammation-Related Biomarkers for Acute Myocardial Infarction Based on Bioinformatics

You,

Dong

2023

JIR

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Previous studies have confirmed that inflammation and immunity are involved in the pathogenesis of acute myocardial infarction (AMI). However, only few related genes are identified as biomarkers for the diagnosis and treatment of AMI. Patients and Methods: GSE48060 and GSE60993 datasets were retrieved from Gene Expression Omnibus. The differentially expressed immuno-inflammation-related genes (DEIIRGs) were obtained from GSE48060, and the biomarkers for AMI were screened and validated using the "Neuralnet" package and GSE60993 dataset. Further, the biomarker-based nomogram was constructed, and miRNAs, transcription factors (TFs), and potential drugs targeting the biomarkers were explored. Furthermore, immune infiltration analysis was analyzed in AMI. Finally, the biomarkers were verified by assessing their mRNA levels using real-time quantitative PCR (RT-qPCR). Results: First, eight biomarkers were screened via bioinformatics, and the artificial neural network model indicated a higher prediction accuracy for AMI even in the validation dataset. Nomogram had accurate forecasting ability for AMI as well. The TFs GTF2I, PHOX2B, RUNX1, and FOS targeting hsa-miR-1297 could regulate the expressions of ADM and CBLB, and RORA could effectively interact with melatonin and citalopram. RT-qPCR results for ADM, PI3, MMP9, NRG1 and CBLB were consistent with those of bioinformatic analysis. Conclusion:In conclusion, eight key immuno-inflammation-related genes, namely, SH2D1B, ADM, PI3, MMP9, NRG1, CBLB, RORA, and FASLG, may serve as the potential biomarkers for AMI, in which the downregulation of CBLB and upregulation of ADM, PI3, and NRG1 in AMI was detected for the first time, providing a new strategy for the diagnosis and treatment of AMI.

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Section: Discussionmentioning

confidence: 99%

Identification of Immuno-Inflammation-Related Biomarkers for Acute Myocardial Infarction Based on Bioinformatics

You,

Dong

2023

JIR

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“…They do not contain a random array of intracellular proteins, but a specific set of several protein families derived from plasma membranes, intracellular pathways, and cytosols [ 21 ]. In fact, exosomes usually contain a variety of biomolecules, including proteins, nucleic acids, lipids, lncRNA and miRNA and even viruses [ 15 , 22 ]. These particles communicate with recipient cells by three mechanisms; they are absorbed by them.…”

Section: Structure and Function Of Exosomementioning

confidence: 99%

“…In fact, exosome is a largely unknown "cell-to-cell" communication system, that is now increasingly considered for diagnostic and therapeutic use in CVD [ 12 ]. As a new type of treatment and diagnostic tool, they are involved in non-invasive assessment of limb response to injury, or in the treatment and development of a reliable treatment method [ 13 – 15 ]. The aim of this study was to evaluate exosomes for the incidence of ECs dysfunction in CVD.…”

Section: Introductionmentioning

confidence: 99%

Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease

et al. 2021

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Exosomes are spherical bilayer membrane vesicles with an average diameter of 40–100 nm. These particles perform a wide range of biological activities due to their contents, including proteins, nucleic acids, lipids, lncRNA, and miRNA. Exosomes are involved in inflammation induction, oxidative stress and apoptosis, which can be effective in endothelial dysfunction. Due to the induction of mentioned processes in the endothelial cells, the intercellular connections are destroyed, cell permeability increases and finally cell efficiency decreases and functional defects occur. Cardiovascular disease (CVDs) are of consequences of endothelial dysfunction. Thus by identifying the exosome signaling pathways, which induce inflammation, oxidative stress, and apoptosis, endothelial dysfunction and subsequently CVDs can be reduced; exosomes can be used for appropriate target therapy.

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“…For example, carrageenan has been used in different sectors such as drug delivery, packaging, and food additives [28,95,96], whereas cellulose has been studied in drug delivery and textiles [97]. Starch has also been explored in food packaging [98,99]; fibrinogen in drug delivery and wound healing [100,101]; silk in wound healing [102,103]; collagen in tissue engineering [104][105][106] and drug delivery [107][108][109]; pullulan in drug delivery [110], food packaging, and food stabilizing [111,112]; alginate in biomedical applications [113,114]; chitin in tissue engineering [115] and enzyme immobilization [116,117]; and collagen in tissue engineering [104][105][106] and drug delivery [107][108][109]. However, our literature search demonstrated that biopolymers have limited applications in water treatment even though they possess useful properties such as hydrophilicity, an optical nature, and an easy-to-functionalize capacity.…”

Section: Biopolymers' Applicationsmentioning

confidence: 99%

Recent Advances in Biopolymeric Membranes towards the Removal of Emerging Organic Pollutants from Water

2021

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Herein, this paper details a comprehensive review on the biopolymeric membrane applications in micropollutants’ removal from wastewater. As such, the implications of utilising non-biodegradable membrane materials are outlined. In comparison, considerations on the concept of utilising nanostructured biodegradable polymeric membranes are also outlined. Such biodegradable polymers under considerations include biopolymers-derived cellulose and carrageenan. The advantages of these biopolymer materials include renewability, biocompatibility, biodegradability, and cost-effectiveness when compared to non-biodegradable polymers. The modifications of the biopolymeric membranes were also deliberated in detail. This included the utilisation of cellulose as matrix support for nanomaterials. Furthermore, attention towards the recent advances on using nanofillers towards the stabilisation and enhancement of biopolymeric membrane performances towards organic contaminants removal. It was noted that most of the biopolymeric membrane applications focused on organic dyes (methyl blue, Congo red, azo dyes), crude oil, hexane, and pharmaceutical chemicals such as tetracycline. However, more studies should be dedicated towards emerging pollutants such as micropollutants. The biopolymeric membrane performances such as rejection capabilities, fouling resistance, and water permeability properties were also outlined.

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The role of exogenous Fibrinogen in cardiac surgery: stop bleeding or induce cardiovascular disease

Cited by 13 publications

References 82 publications

Identification of Immuno-Inflammation-Related Biomarkers for Acute Myocardial Infarction Based on Bioinformatics

Identification of Immuno-Inflammation-Related Biomarkers for Acute Myocardial Infarction Based on Bioinformatics

Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease

Recent Advances in Biopolymeric Membranes towards the Removal of Emerging Organic Pollutants from Water

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