The role of estrogen and testosterone in female rats in behavioral models of relevance to schizophrenia

Gogos, Andrea; Kwek, Perrin; Buuse, Maarten van den

doi:10.1007/s00213-011-2389-y

Cited by 56 publications

(42 citation statements)

References 52 publications

(61 reference statements)

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“…Whatever precise mechanisms involved, our findings clearly add to the growing literature suggesting that estrogen--related substances may have therapeutic value in the treatment of psychosis--related behavioral and cognitive deficits (Arad and Weiner, 2010b;Frye et al 2007;Gogos et al 2006Gogos et al , 2010Gogos et al , 2012Uban et al 2012;Van den Buuse and Eikelis, 2001). For instance the ER--α agonist PPT seems to represent a remarkably potent pharmacological compound that could possibly modulate PPI in populations of patients with sensorimotor gating pathologies of distinct etiology/pathophysiology given its significant effects on PPI both in normo--dopaminergic and hyper--dopaminergic states.…”

Section: Discussionsupporting

confidence: 56%

“…These findings readily emphasize a putative role of dopamine--dependent mechanisms in the behavioral actions of ER--α and ER--β selective agonists. In support of this notion, E2 is known to affect dopaminergic neurocircuits (Sánchez et al 2010), and it has been proposed that such effects readily contribute to the modulatory effects of E2 on sensorimotor gating in the form of PPI (Gogos et al , 2012. Moreover, ER--α and ER--β are both expressed in some of the most important brain areas involved in the PPI circuitry, including the (ventral) striatum and midbrain dopaminergic nuclei (Kuppers and Beyer, 1999;Laflamme et al 1998;Shughrue et al 1997;Toran--Allerand, 2004).…”

Section: Discussionmentioning

confidence: 97%

“…Indeed, E2 was previously shown to blunt the deleterious effects of the NMDA antagonist MK--801 on PPI (Gogos et al 2012;Van den Buuse and Eikelis, 2001) and on selective attention learning (Arad and Weiner, 2010b). Several studies have further implicated 5--HT1 and 5--HT2A serotonergic receptors in the behavioral effects of E2 and related ligands (Cyr et al 2002;Fink et al 1998;Gogos et al 2012;Weiner and Arad, 2009). …”

Section: Discussionmentioning

confidence: 99%

“…PPI thus reflects the ability to filter or gate intrusive sensory--motor information. Disruption of such filtering mechanisms can result in central stimulus overload and associated dysfunctions in allocating the limited brain resources to only the most important stimuli encountered in the environment, and such abnormalities appear to be a core deficit in psychosis--related disease (Braff et al 2001 Gogos et al 2006Gogos et al , 2010Gogos et al , 2012. Such investigations have, however, largely focused on females, whilst the putative benefits of estrogen--receptor (ER)--based ligands for treating schizophrenia--relevant symptoms in males has attained less attention (Arad and Weiner, 2010a,b;Kulkarni et al 2009Kulkarni et al , 2011Kulkarni et al , 2013).…”

Section: Introductionmentioning

confidence: 99%

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Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice

2015

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Rationale. Multiple lines of evidence suggest that the sex steroid hormone 17--β estradiol (E2) plays a protective role in schizophrenia. Systemic E2 enhances prepulse inhibition (PPI) of the acoustic startle reflex, an operational measure of sensorimotor gating known to be impaired in schizophrenia and related disorders. However, the relative contribution of different estrogen--receptor (ER) isoforms in these associations still awaits examination. Results. Acute pharmacological stimulation and blockade of ER--α, respectively, led to a dose--dependent increase and decrease in basal PPI. In contrast, acute treatment with preferential ER--β modulators spared PPI under basal conditions. Pretreatment with either ER--α or ER--β agonist was, however, effective in blocking amphetamine--induced PPI disruption. Conclusions.Our study demonstrates that activation of either ER isoform is capable of modulating dopamine--dependent PPI levels. At the same time, our results suggest that endogenous ER--α signaling may be more relevant than ER--β in the regulation of sensorimotor gating under basal conditions.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice

2015

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“…Additionally, some 'neuro-protective' effects of estrogen on DA and 5-HT NT system-related behaviours have been found, with estrogen exhibiting an ability to inhibit the DA D 2 and 5-HT 1A receptorinduced mediated behavioural changes in sensorimotor gating/information processing, which are deficient in people with mental illnesses (Dunlop and Nemeroff 2007;Gogos et al 2012). …”

Section: Discussionmentioning

confidence: 99%

Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats

et al. 2015

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. (2016). Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats. Journal of Psychopharmacology, 30 (2),[204][205][206][207][208][209][210][211][212][213][214] Early antipsychotic treatment in childhood/adolescent period has longterm effects on depressive-like, anxiety-like and locomotor behaviours in adult rats AbstractChildhood/adolescent antipsychotic drug (APD) use is exponentially increasing worldwide, despite limited knowledge of the long-term effects of early APD treatment. Whilst investigations have found that early treatment has resulted in some alterations to dopamine and serotonin neurotransmission systems (essential to APD efficacy), there have only been limited studies into potential long-term behavioural changes. This study, using an animal model for childhood/adolescent APD treatment, investigated the long-term effects of aripiprazole, olanzapine and risperidone on adult behaviours of male and female rats. Open-field/holeboard, elevated plus maze (EPM), social interaction and forced swim (FS) tests were then conducted in adult rats. Our results indicated that in the male cohort, early risperidone and olanzapine treatment elicited long-term hyper-locomotor effects (open-field/holeboard and FS tests), whilst a decrease in depressive-like behaviour (in FS test) was observed in response to olanzapine treatment. Furthermore, anxiolytic-like behaviours were found following testing in the open-field/holeboard and EPM in response to all three drug treatments. Effects in the female cohort, however, were to a far lesser extent, with behavioural attributes indicative of an increased depressive-like behaviour and hypo-locomotor activity exhibited in the FS test following early risperidone and olanzapine treatment. These results suggest that various APDs have different long-term effects on the behaviours of adult rats.

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Physiological Correlates of Premenstrual Dysphoric Disorder (PMDD)

Sundström‐Poromaa

2014

Electrophysiology and Psychophysiology in Psychiatry and Psychopharmacology

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Premenstrual dysphoric disorder (PMDD) is a mood disorder with onset of functionally impairing or distressing mood symptoms in the late luteal phase of the menstrual cycle. Psychophysiologic findings in PMDD broadly fall into two categories: vulnerability trait findings, thus categorized because they are present in the asymptomatic phases of the menstrual cycle, and state findings, which are only present in the symptomatic late luteal phase and which are potentially representative of the hormonal events and biological mechanisms that lead to PMDD. Trait vulnerability markers in PMDD include diminished cardiovascular stress responses, lower heart rate variability (reflecting increased vagal tone), and lower P300 amplitude, eventually suggesting that women with PMDD share a number of physiological correlates with related anxiety and mood disorders. State findings in PMDD include lower luteal phase prepulse inhibition and altered luteal phase emotion processing. Lower prepulse inhibition in the late luteal phase may be an important ovarian steroid-influenced indicative of altered serotonergic neurotransmission, of relevance for women with PMDD. Attempts to determine the neural correlates of emotion processing in the late luteal phase are thus far inconsistent, but promising.

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The role of estrogen and testosterone in female rats in behavioral models of relevance to schizophrenia

Abstract: Estrogen is functionally protective against 5-HT(1A)-, dopamine D(2)-, and NMDA receptor-induced PPI disruptions, while testosterone treatment enhances NMDA receptor-mediated PPI disruptions.

Cited by 56 publications

References 52 publications

Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice

Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice

Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats

Physiological Correlates of Premenstrual Dysphoric Disorder (PMDD)

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