The role of erythropoietin in hemorrhagic shock-induced liver and renal injury in rats

Algın, Mustafa Cem; Hacioğlu, Alper; Yaylak, Faik; Gülcan, Erim; Aydın, Taner; Hacioglu, Buket Altunkara; Ilhan, Demet; Çevik, Arif Alper; Ateş, Ersin

doi:10.1007/s12325-008-0114-y

Cited by 10 publications

(5 citation statements)

References 46 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In studies examining liver I/R damage in HS, rhEPO was shown to prevent liver damage. Comparision of effects of intravenous EPO given 60 minutes before and 30 minutes after experimental HS in rats in a study revealed that EPO is more effective in reducing liver damage if it is given before HS occurs (12). In a later experimental HS study, it was shown that EPO given three hours before the induction of HS significantly attenuated renal, hepatic and neuromuscular injury and dysfunction caused by HS (13).…”

Section: Discussionmentioning

confidence: 99%

“…In studies investigating post-MI liver tissue, the effects of betaine (an essential organic osmolyte) (3) and tribulus terrestris (a fruit) (5) have been examined. Previous studies on ischemic liver mostly focused on cold ischemia and reperfusion during liver transplantation (6)(7)(8)(9)(10)(11) or hemorrhagic shock (12)(13)(14). Studies investigating the effects of erythropoietin (EPO), which is the main hemopoietic hormone, for the prevention of cold ischemia in the liver that occur during transplantation started with Yilmaz (11).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Eritropoietinin MI Sonrası Karaciğer Dokusu Üzerinde Koruyucu Etkisi

GÜLEN

Bağla

Kaya

et al. 2022

Sağlık Bilimlerinde Değer

View full text Add to dashboard Cite

Aim: Cardiac hepatopathy arises due to heart failure and influences has effects on heart recovery after myocardial infarction (MI).The aim of this study was to investigate the protective effect of Erythropoietin (EPO) on liver tissue exposed to ischemia due to MI. Material and Methods: Experimental MI was established by left anterior descending coronary artery ligation (CAL) and EPO or saline was injected immediately after CAL to five groups of rats, which groups are Control, Saline, EPO 5000, EPO 10000, CAL+1h. CAL+1h group was sacrificed one hour after CAL without any treatment. Other groups were sacrificed six hours after the operation. Liver tissues were examined histopathologically by Hematoxylin Eosin (HE) staining and electron microscopy. Results: Degenerative changes in liver tissue such as vacuolization, sinusoidal dilatation, hepatocyte pyknosis, Kuppfer cell activation were observed. Vacuolization, and sinusoidal dilatation increased in the Saline group compared to the control group (p=0.010 for both). Degenerated hepatocytes with pyknotic nuclei as well as activated Kuppfer cells were decreased in the EPO 10000 group compared to the Saline group (p=0.009), and activated Kupfer cells were decreased compared to the Saline and CAL+1h groups (p=0.035 and p=0.019, respectively). Conclusion: EPO protected liver tissue from histopathological damages regardless of dose, when given at the time of MI. EPO, when given immediately after MI, protected liver tissue from histopathological damage regardless of dose. Considering the mutual interaction of liver and heart, applying EPO to MI patients at first sight may prevent post-MI liver damage and contribute to the recovery of the heart.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eritropoietinin MI Sonrası Karaciğer Dokusu Üzerinde Koruyucu Etkisi

GÜLEN

Bağla

Kaya

et al. 2022

Sağlık Bilimlerinde Değer

View full text Add to dashboard Cite

show abstract

“…5a). It has been reported that unbalanced immunoinflammatory reactions triggered by shock or trauma are linked to multiple organ failure, and multiple organ failure is the primary cause of the increased morbidity and mortality in patients with severe trauma or hemorrhagic shock (Bahrami et al 2006;Algin et al 2008). More specifically, the increase in systemic proinflammatory cytokines was associated with cellular injury and remote organ dysfunction, and these cytokines have been reported to play a role in the complex development mechanism of aggravated hepatic injury due to ischemiareperfusion (Sharma et al 2003;Prince et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock

Huang

Dong

2015

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

This study examined the effects of polyethylene oxide (PEO) on the survival rate, hemodynamics, blood gas indexes, lactic acid levels, microcirculation, and inflammatory cytokine levels in rats subjected to severe hemorrhagic shock. The shocked rats were resuscitated with either Ringer's lactate solution or 20 ppm of PEO in Ringer's lactate solution for 1 h. It was found that infusion of PEO effectively improved the survival, metabolic acidosis, oxygen delivery, hyperlactacidemia, tissue perfusion, and inflammatory responses of rats subjected to hemorrhagic shock. In addition, we found, for the first time, that PEO showed protective effects on hepatic and renal injury, as evidenced by the significant decreases in the elevated levels of alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, and creatinine caused by shock induction after infusion of PEO (p < 0.05, 60 min post-resuscitation by comparison with pre-resuscitation). All of these findings indicate that PEO exhibits strong therapeutic effects under conditions of severe hemorrhagic shock,which also provides theoretical and experimental bases for the clinical use of PEO.

show abstract

“…The effect of genistein is exerted through the blocking of the estrogenic effect. However, in another study [146], genistein (10 mg/kg, 30 min before hemorrhagic shock) reduced kidney injury during ischemic shock in rats by inhibiting inflammation. However, the effect of genistein on vasoconstriction was not studied.…”

Section: The Effects Of Genistein On Kidney Ischemia/reperfusion Injurymentioning

confidence: 92%

Effects of Genistein on Common Kidney Diseases

Peng

Shang

et al. 2022

Nutrients

View full text Add to dashboard Cite

Genistein is a naturally occurring phytoestrogen (soy or soybean products) that is classified as an isoflavone, and its structure is similar to that of endogenous estrogens; therefore, genistein can exert an estrogen-like effect via estrogen receptors. Additionally, genistein is a tyrosine kinase inhibitor, which enables it to block abnormal cell growth and proliferation signals through the inhibition of tyrosine kinase. Genistein is also an angiogenesis inhibitor and an antioxidant. Genistein has effects on kidney cells, some of the kidney’s physiological functions, and a variety of kidney diseases. First, genistein exerts a protective effect on normal cells by reducing the inflammatory response, inhibiting apoptosis, inhibiting oxidative stress, inhibiting remodeling, etc., but after cell injury, the protective effect of genistein decreases or even has the opposite effect. Second, genistein can regulate renin intake to maintain blood pressure balance, regulate calcium uptake to regulate Ca2+ and Pi balances, and reduce vasodilation to promote diuresis. Third, genistein has beneficial effects on a variety of kidney diseases (including acute kidney disease, kidney cancer, and different chronic kidney diseases), such as reducing symptoms, delaying disease progression, and improving prognosis. Therefore, this paper reviews animal and human studies on the protective effects of genistein on the kidney in vivo and in vitro to provide a reference for clinical research in the future.

show abstract

The role of erythropoietin in hemorrhagic shock-induced liver and renal injury in rats

Abstract: These results suggest that EPO is effective in attenuating liver and renal injury in HS, even with inhibition of tyrosine kinase activity with genistein.

Cited by 10 publications

References 46 publications

Eritropoietinin MI Sonrası Karaciğer Dokusu Üzerinde Koruyucu Etkisi

Eritropoietinin MI Sonrası Karaciğer Dokusu Üzerinde Koruyucu Etkisi

Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock

Effects of Genistein on Common Kidney Diseases

Contact Info

Product

Resources

About