The role of erythropoietin in the acute phase of trauma management: Evidence today

Kanakaris, Nikolaos K.; Petsatodis, George; Chalidis, Byron; Manidakis, Nikolaos; Kontakis, Georgios; Giannoudis, PV

doi:10.1016/j.injury.2008.09.006

Cited by 11 publications

(8 citation statements)

References 87 publications

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“…There is a great requirement for additional and affordable anabolic treatments to remedy impaired fracture healing. The evidence supporting the close association of BMPs with bone metabolism and the identification of the role of BMPs in the process of fracture healing and the pathogenesis of osteoporosis makes them attractive target molecules for the development of anabolic therapies for the prevention as well as for the treatment of osteoporotic fractures (29,30). Consistent with other studies, which have reported enhanced fracture repair and stimulated early new bone formation with rhBMP-2 treatment in ovariectomized rats (7,8), the present study indicated that rhBMP-2 has a positive effect on fracture healing in estrogen-deficient mice.…”

Section: Discussionmentioning

confidence: 99%

Combination therapy with BMP‑2 and psoralen enhances fracture healing in ovariectomized mice

Huang

et al. 2018

Exp Ther Med

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The advantages of combining local delivery of bone morphogenetic protein (BMP)-2 with systemic or local anti-osteoporosis treatments have also been studied for enhancing osteoporotic fracture healing. The aim of the present study was to evaluate the effect of combination therapy with BMP-2 and psoralen on fracture repair in ovariectomized mice. At 6 weeks after bilateral ovariectomy, mice (n=30) underwent unilateral transverse osteotomy on the femur and were divided into 3 groups. In the model group (n=10), animals were implanted with an absorbable collagen sponge (ACS) alone and administered physiological saline intragastrically (i.g.). In the recombinant human (rh)BMP-2 group (n=10), animals were implanted with an ACS loaded with 2.5 µg rhBMP-2 and administered physiological saline i.g. In the psoralen + rhBMP-2 group (n=10) animals were implanted with an ACS loaded with 2.5 µg rhBMP-2 and administered psoralen i.g. The mice were euthanized after 21 days and their fractured femurs were assessed by micro computed tomography, histological analysis and biomechanical testing. Furthermore, the serum of the animals was analyzed. Psoralen + rhBMP-2 exerted more beneficial effects on callus consolidation and biomechanical strength. In addition, increased bone-specific alkaline phosphatase levels and decreased C-terminal telopeptide of type-1 collagen were observed in the Psoralen + rhBMP-2 group. However, no difference in estrogen levels was detected between the groups. In conclusion, the present study demonstrated that in ovariectomized mice, combination of locally delivered BMP-2 and systemically administered psoralen improved bone healing compared with BMP-2 alone.

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Section: Discussionmentioning

confidence: 99%

Combination therapy with BMP‑2 and psoralen enhances fracture healing in ovariectomized mice

Huang

et al. 2018

Exp Ther Med

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“…Strategies include synthetic coagulation factors, antifibrinolytics, Vitamin K, blood conservation techniques designed to minimize loss associated with therapeutic interventions, recombinant human erythropoietin (EPO), iron, supplementary vitamins (e.g. B12, C, folate) and replacement of oxygen‐carrying capacity by haemoglobin‐based oxygen carriers (HBOC) .…”

Section: Introductionmentioning

confidence: 99%

Management of injured patients who were Jehovah's Witnesses, where blood transfusion may not be an option: a retrospective review

et al. 2018

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“…Since the discovery of BMPs in 1965 [13], the central role of BMPs in human skeletal remodeling has been identified in numerous in vitro, in vivo and clinical studies [14,15]. More than 40 members of the BMP family have been identified, and BMPs have been implicated in the healing of osteoporotic fractures because of their key role in osteogenic differentiation and bone formation.…”

Section: Introductionmentioning

confidence: 99%

“…More than 40 members of the BMP family have been identified, and BMPs have been implicated in the healing of osteoporotic fractures because of their key role in osteogenic differentiation and bone formation. Among the many different BMPs, BMP-2, BMP-4, BMP-6 and BMP-7 are the most studied in osteoporosis and have been associated with its pathways [14]. Many studies have shown that BMP-2, BMP-4, BMP-6 or BMP-7 can regulate osteogenic differentiation of MSCs and bone regeneration both in vitro and in vivo [16,17,18,19,20].…”

Section: Introductionmentioning

confidence: 99%

Screening of Osteogenic-Enhancing Short Peptides from BMPs for Biomimetic Material Applications

et al. 2016

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Bone regeneration is an important issue in many situations, such as bone fracture and surgery. Umbilical cord mesenchymal stem cells (UC-MSCs) are promising cell sources for bone regeneration. Bone morphogenetic proteins and their bioactive peptides are biomolecules known to enhance the osteogenic differentiation of MSCs. However, fibrosis can arise during the development of implantable biomaterials. Therefore, it is important to control cell organization by enhancing osteogenic proliferation and differentiation and inhibiting fibroblast proliferation. Thus, we focused on the screening of such osteogenic-enhancing peptides. In the present study, we developed new peptide array screening platforms to evaluate cell proliferation and alkaline phosphatase activity in osteoblasts, UC-MSCs and fibroblasts. The conditions for the screening platform were first defined using UC-MSCs and an osteogenic differentiation peptide known as W9. Next, in silico screening to define the candidate peptides was carried out to evaluate the homology of 19 bone morphogenetic proteins. Twenty-five candidate 9-mer peptides were selected for screening. Finally, the screening of osteogenic-enhancing (osteogenic cell-selective proliferation and osteogenic differentiation) short peptide was carried out using the peptide array method, and three osteogenic-enhancing peptides were identified, confirming the validity of this screening.

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The role of erythropoietin in the acute phase of trauma management: Evidence today

Cited by 11 publications

References 87 publications

Combination therapy with BMP‑2 and psoralen enhances fracture healing in ovariectomized mice

Combination therapy with BMP‑2 and psoralen enhances fracture healing in ovariectomized mice

Management of injured patients who were Jehovah's Witnesses, where blood transfusion may not be an option: a retrospective review

Screening of Osteogenic-Enhancing Short Peptides from BMPs for Biomimetic Material Applications

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