In the course of work with the purpose of developing a complex pathopsychologically grounded system of psychotherapy and psychoprophylaxis for students of higher educational institutions with depressive disorders of affective (DDAR) and neurotic (DDNR) registers, a complex psychodiagnostic, psychometric, and clinical and psychopathological study of 200 students from various universities at the age of 17-24 was conducted. According to the results of the study, it was revealed that the effect of factors related to the start of studies at the university results in the highest probability of depressive disorders of the neurotic register among younger students. Students of senior years are maximally adapted to the conditions of study; therefore, the incidence of these disorders, both clinical and subclinical, is average among them, whereas in senior years there is an increase in the incidence of depressive disorders of the affective register. The article also presents the diagnostic results of studying the emotional sphere of students, the syndromological structure of depressive disorders of both registers, and formulated recommendations on the diagnosis and treatment of patients with depressions in the primary medical system.