The Role of Domestic Animals in the Epidemiology of Plague. II. Antibody to Yersinia pestis in Sera of Dogs and Cats

Rust, James H.; Miller, Bryan E.; Bahmanyar, M.; Marshall, John D.; Purnaveja, S.; Cavanaugh, Dan C.; Hla, U. S. T.

doi:10.1093/infdis/124.5.527

Cited by 54 publications

(36 citation statements)

References 7 publications

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“…21 In addition, exposure to plague-infected companion animals has been previously identified as a risk factor. [24][25][26] Other studies suggested that poor, unsanitary conditions are responsible for plague epidemics, because these conditions promote cohabitation of homes by humans and competent rodent hosts, which ultimately increases the potential of transmission. 21,27,28 Our study focuses on the plague-endemic West Nile region of Uganda, where, from 1999 to 2007, a mean of 223 human plague cases was reported annually to the Ugandan Ministry of Health.…”

Section: Introductionmentioning

confidence: 99%

Landscape and Residential Variables Associated with Plague-Endemic Villages in the West Nile Region of Uganda

MacMillan¹,

Enscore²,

Ogen-Odoi³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Abstract. Plague, caused by the bacteria Yersinia pestis , is a severe, often fatal disease. This study focuses on the plagueendemic West Nile region of Uganda, where limited information is available regarding environmental and behavioral risk factors associated with plague infection. We conducted observational surveys of 10 randomly selected huts within historically classified case and control villages (four each) two times during the dry season of 2006 ( N = 78 case huts and N = 80 control huts), which immediately preceded a large plague outbreak. By coupling a previously published landscape-level statistical model of plague risk with this observational survey, we were able to identify potential residence-based risk factors for plague associated with huts within historic case or control villages (e.g., distance to neighboring homestead and presence of pigs near the home) and huts within areas previously predicted as elevated risk or low risk (e.g., corn and other annual crops grown near the home, water storage in the home, and processed commercial foods stored in the home). The identified variables are consistent with current ecologic theories on plague transmission dynamics. This preliminary study serves as a foundation for future case control studies in the area.

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Section: Introductionmentioning

confidence: 99%

Landscape and Residential Variables Associated with Plague-Endemic Villages in the West Nile Region of Uganda

MacMillan¹,

Enscore²,

Ogen-Odoi³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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“…Persistence of antibodies against Y. pestis has already been evaluated in dogs aged 4 to 8 months (Rust et al, 1971). The presence of seropositivity in dogs indicates recent local activity and serological studies in dogs are easier than catching rodents.…”

Section: Resultsmentioning

confidence: 99%

Seroprevalence of Yersinia pestis in dogs and small rodents in one hyperendemic plague focus of Democratic Republic of Congo

Davoust¹,

Diatta²,

Shako³

et al. 2013

Afr. J. Microbiol. Res.

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Plague is endemic in Ituri of the Democratic Republic of Congo. In order to evaluate the role of commensal rodents and domestic dogs in the spread of the disease, we studied the seroprevalence at Rethy. Results showed that the 27/28 small rodents were seronegative (using immunoglobulin G anti-F1 enzyme-linked immunosorbent assay), but one of them, Nile rat was positive. These rodents serve as intermediaries, spreading the disease to domiciliary black rats. Of the 11 dogs tested by ELISA, 4 were seropositive (36%). Our results confirm that the serological prevalence in dogs is a reliable marker for the surveillance of plague.

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“…The role of pet animals, such as cats and dogs, in transmission has been suggested in past studies and anecdotally reported on several occasions [138][139][140]. Yet a more recent study provides supportive evidence that pet animals may play a more significant role in transmission of plague in endemic regions (e.g.…”

Section: Other Factors To Be Considered In the Re-emergence Of Plaguementioning

confidence: 94%

“…While dogs typically experience a milder form of the illness, presenting with nonspecific signs like lethargy, pyrexia, and purulent skin lesions, cats are highly susceptible to plague, presenting with a disease spectrum similar to that in humans and mortality in untreated cats is equally high [143]. Studies evaluating the serologic response to plague demonstrated that dogs in enzootic areas are frequently exposed to either infected rodents or rodent-fleas [139], cats are more likely to be exposed via predation on diseased animals and rodents. In both instances, caring for a diseased pet (cat or dog), or allowing close contact with a diseased pet dog (e.g.…”

Section: Other Factors To Be Considered In the Re-emergence Of Plaguementioning

confidence: 99%

Lessons Learned from Historic Plague Epidemics: The Relevance of an Ancient Disease in Modern Times

Boire¹

2014

J Anc Dis Prev Rem

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The Role of Domestic Animals in the Epidemiology of Plague. II. Antibody to Yersinia pestis in Sera of Dogs and Cats

Cited by 54 publications

References 7 publications

Landscape and Residential Variables Associated with Plague-Endemic Villages in the West Nile Region of Uganda

Landscape and Residential Variables Associated with Plague-Endemic Villages in the West Nile Region of Uganda

Seroprevalence of Yersinia pestis in dogs and small rodents in one hyperendemic plague focus of Democratic Republic of Congo

Lessons Learned from Historic Plague Epidemics: The Relevance of an Ancient Disease in Modern Times

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