The Role of Different Inflammatory Indices in the Diagnosis of COVID-19

Eissa, Marwa Sayed Abdel Latif; Shaarawy, Sabry; Abdellateif, Mona S.

doi:10.2147/ijgm.s337488

“…Chen et al [ 24 ] have demonstrated that SIRI was an effective inflammatory marker to estimate hyperuricaemia in rural Chinese women and was likely to optimise the risk stratification and prevention of hyperuricaemia. A recent study [ 25 ] has shown that SIRI was significantly higher in patients with coronavirus disease 2019 (COVID-19) than those in the control group, whereas its diagnostic value in COVID-19 was moderate. In this study, SIRI was used for the early diagnosis of CRBSI in patients undergoing haemodialysis for the first time, and the diagnostic effect was increasing.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Systemic Inflammatory Response Index for Catheter-Related Bloodstream Infection in Patients Undergoing Haemodialysis

Yang

¹

,

Wang

²

,

Hua

³

et al. 2022

Journal of Immunology Research

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Objective. This study was aimed at investigating the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein-to-albumin ratio (CAR), and systemic inflammatory response index (SIRI) for catheter-related bloodstream infection (CRBSI) in patients undergoing haemodialysis. Methods. A total of 296 patients undergoing haemodialysis with vascular access were selected and divided into the infected (58 patients) and uninfected (238 patients) groups. Their aetiological and general characteristics were retrospectively collected. The NLR, PLR, CAR, and SIRI were calculated. Results. The NLR, PLR, CAR, and SIRI values in the infected group were significantly higher than those in the uninfected group ( P < 0.05 ). After the anti-infective treatment, the NLR, PLR, CAR, and SIRI values in patients with CRBSI were significantly decreased ( P < 0.05 ). The NLR, CAR, and SIRI showed diagnostic efficacy in patients with CRBSI with cut-off values of 4.485 ( area under the curve AUC = 0.827 , 95 % confidence interval CI = 0.768 – 0.887 ), 0.975 ( AUC = 0.836 , 95 % CI = 0.779 – 0.892 ), and 3.390 ( AUC = 0.947 , 95 % CI = 0.919 – 0.976 ). The CAR and SIRI values in patients with gram-negative bacterial infection were significantly higher than those with gram-positive bacterial infection ( P < 0.05 ). The AUCs of CAR and SIRI were 0.693 (0.537–0.848) and 0.821 (0.700–0.942) in differentiating gram-negative and gram-positive bacterial infections, respectively. Conclusion. Our results showed SIRI as a novel and efficient indicator for the early diagnosis of CRBSI in patients undergoing haemodialysis.

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“…This demonstrates the importance of parameters that can predict poor outcome in patients with COVID-19. It is known that indices calculated by whole blood parameters alone or by their ratios to each other can be used to show systemic inflammation in COVID-19 and many cancers (9). This study was aimed to evaluate the value of inflammation parameters in predicting ICU admission and mortality in patients with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“…Parameters such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic inflammation index (SII), monocyte to lymphocyte ratio, derived NLR (dNLR), mean platelet volume to platelet ratio (MPR), lymphocyte to monocyte ratio (LMR), C-reactive protein (CRP) albumin ratio (CAR), CRP lymphocyte ratio (CRP/L), neutrophil to lymphocyte, platelet ratio (NLPR), systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI) have been studied in many inflammatory diseases and cancers and also the role of them in the diagnosis, prognosis and follow-up of patients with COVID-19 has also been studied (6,7,8,9,10).…”

Section: Introductionmentioning

confidence: 99%

The Role of Inflammatory Parameters in the Prognosis of Patients with COVID-19

Canoğlu¹,

Çalışkan²,

Sinmez³

et al. 2022

hamidiyemedj

0

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Background:The prognostic significance of inflammatory parameters in patients with Coronavirus disease-2019 (COVID-19) has been investigated. Materials and Methods:Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, C-reactive protein (CRP) albumin ratio (CAR), systemic inflammation index (SII), CRP-lymphocyte ratio (CRP/L), neutrophil to lymphocyte, platelet ratio (NLPR), red cell volume distribution width index (RDW-SD), and procalcitonin were evaluated in relation to admission to intensive care unit (ICU) and mortality in 419 patients with moderate-to-severe COVID-19.Results: NLR, CAR, CRP/L, NLPR, RDW-SD and procalcitonin levels were higher both in those who needed ICU compared to those who did not (p=0.001, 0.005, 0.002, 0.001, 0.001 and 0.001; respectively), and in those who died compared to the survival group (p=0.001, 0.024, 0.009, 0.001, 0.001 and 0.001; respectively). SII was higher only in those who needed ICU (p=0.001). NLR (0.610, p=0.002), CAR (0.602, p=0.005), SII (0.573, p=0.043), CRP/L (0.593, p=0.010), and NLPR (0.618, p=0.001) were statistically significant for admission to ICU; and NLR (0.637, p=0.006), CAR (0.613, p=0.024), CRP/L (0.605, p=0.035) and NLPR (0.660, p=0.001) were statistically significant for mortality in the evaluation of area under curve in ROC analysis. RDW-SD was an independent risk factor for both ICU admission [odds ratio (OR): 1.194, p=0.024] and mortality (OR: 1.263, p=0.002), and procalcitonin was an independent risk factor for ICU admission (OR: 1.492, p=0.034) in multivariate analysis. Conclusion:NLR, CAR, CRP/L, NLPR, RDW-SD and procalcitonin were determined as prognostic parameters in terms of both the need for ICU and mortality in patients with COVID-19. SII was a prognostic parameter only for the need for ICU.

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“…Severe cases had significantly lower P/N counts compared to moderately severe COVID‐19 patients. Eissa et al 37 identified neutrophil to lymphocyte to platelet ratio (NLPR) > 0.011 (OR = 38.751) and CRP/L > 7.6 (OR = 7.604) as being independent diagnostic factors for COVID‐19 among several different inflammatory indices. Another research revealed that neutrophil‐to‐platelet ratio (NPR) had the highest predictive value at ICU admission among COVID‐19 patients in multivariable logistic regression models with NLR, PLR, and SII 38 .…”

Section: Discussionmentioning

confidence: 99%

Platelet‐derived immuno‐inflammatory indices show best performance in early prediction of COVID‐19 progression

Milenković

¹

,

Djindjić

²

,

Djordjević

³

et al. 2022

Clinical Laboratory Analysis

4

0

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Background Coronavirus disease 2019 (COVID‐19) profoundly affects the immune and hematopoietic systems with various degrees of reactive changes in the blood cell counts. Immuno‐inflammatory indices are considered a simple and effective tool in the prediction of COVID‐19 outcomes. We aimed to evaluate and compare the usefulness of leukocyte and platelet counts‐based immuno‐inflammatory indices on admission to hospital in predicting COVID‐19 progression and mortality. Methods A total of 945 patients were enrolled. In addition to blood cell counts, we assessed hemogram‐derived immuno‐inflammatory indices in relation to COVID‐19 progression and death. The indices were tested by analysis of variance, receiver operating characteristic curve analysis, and binomial logistic regressions. Results Patients with severe COVID‐19 had significantly higher counts of neutrophils, eosinophils, and large immature cells (LIC), while decreased counts of platelets and monocytes. Lymphopenia was found in all of the patients, but without significant association with the outcomes. Patients with a LIC count ≥0.265 x 0 9 /L had 54.7% more odds of having COVID‐19 progression. In multivariable analyses, platelets/neutrophil‐to‐lymphocyte ratio (P/NLR) and platelets‐to‐neutrophil radio (P/N) were significant independent predictors of COVID‐19 progression and mortality. The odds of a poor outcome were two times higher in cases with P/NLR < 43 x 10 9 /L and P/N < 29 x 10 9 /L. Conclusion Indices that include platelet count in combination with neutrophil and/or lymphocyte counts displayed the best discriminatory ability and prognostic value of COVID‐19 outcomes. Additionally, LIC showed promising results in the early identification of severe COVID‐19.

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The Role of Different Inflammatory Indices in the Diagnosis of COVID-19

Cited by 31 publications

References 46 publications

Diagnostic Value of Systemic Inflammatory Response Index for Catheter-Related Bloodstream Infection in Patients Undergoing Haemodialysis

Diagnostic Value of Systemic Inflammatory Response Index for Catheter-Related Bloodstream Infection in Patients Undergoing Haemodialysis

The Role of Inflammatory Parameters in the Prognosis of Patients with COVID-19

Platelet‐derived immuno‐inflammatory indices show best performance in early prediction of COVID‐19 progression

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