The role of depression in the relationship between cognitive decline and quality of life among breast cancer patients

Park, Jin Hee; Jung, Yuh‐Seog; Jung, Young-Mi; Bae, Sun Hyoung

doi:10.1007/s00520-018-4546-x

Cited by 32 publications

(26 citation statements)

References 28 publications

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“…Milbury et al reported that the mean score of QOL was 104.12 ± 14.77 in USA during the year 2017 [ 45 ], Matthies et al reported a mean QOL score of 102.66 ± 22 in Germany during the year 2019 [ 46 ]. However, the mean QOL score observed in our investigation was closer to the Asian situation-the mean score of QOL in Korea was 91.26 ± 20.08 as reported by Park et al in 2019 [ 47 ]. QOL in the current study was at a lower level in its individual capacity possibly because of three reasons.…”

Section: Discussionsupporting

confidence: 81%

The effect of fear of progression on quality of life among breast cancer patients: the mediating role of social support

Ban

et al. 2021

Health Qual Life Outcomes

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Background Women with breast cancer are prone to have mental stress and be stimulated by the fear of progression (FOP), then giving rise to a lower quality of life (QOL). The study aimed to examine the relationships between FOP, social support and QOL, and further explore whether social support mediates the association between FOP and QOL among Chinese patients with breast cancer. Methods The cross-sectional study was conducted from October 2019 to May 2020 at Anshan Cancer Hospital in Liaoning, China. 244 female breast cancer patients completed questionnaires including the Functional Assessment of Cancer Therapy for Breast (FACT-B), Multi-Dimensional Scale of Perceived Social Support (MSPSS), and Fear of Progression (FOP). Hierarchical multiple regression analysis was performed to assess the associations between FOP, social support and QOL. Asymptotic and resampling strategies were used to explore the mediating role of social support. Results The mean QOL score was 90.6 ± 17.0 among the patients with breast cancer. FOP was negatively correlated with QOL, while social support was positively related to QOL. Social support partly mediated the association between FOP and QOL, and the proportion of the mediating effect accounted for by social support was 25%. Conclusions Chinese breast cancer patients expressed low QOL. Social support could mediate the association between FOP and QOL. Medical staffs and cancer caregivers should alleviate patients’ FOP to improve their QOL by facilitating social support.

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Section: Discussionsupporting

confidence: 81%

The effect of fear of progression on quality of life among breast cancer patients: the mediating role of social support

Ban

et al. 2021

Health Qual Life Outcomes

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“…However, BC poses many challenges during treatment, including the lack of breast tissue, sleep disorders, and anxiety. These challenges can trigger psychological distress [5], whose impact may extend far beyond the period of diagnosis and treatment, and this problem is receiving more attention [6]. Positive psychological reactions can improve patients' quality of life, whereas negative reactions can have the opposite effect.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Among Rumination, Coping Strategies, and Subjective Well-being in Chinese Patients With Breast Cancer: A Cross-sectional study

Liu

Jiang

Shi

2020

Asian Nursing Research

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Purpose: To investigate the relationship between rumination, coping strategies, and subjective wellbeing (SWB) and test the mediating effects of coping strategies on rumination and SWB in patients with breast cancer (BC). Methods: This cross-sectional study assessed rumination, coping strategies, and SWB using the General Well-being Schedule, the Chinese Event-Related Rumination Inventory, and the Medical Coping Modes Questionnaire in BC patients admitted to a tertiary general hospital in China. Results: SWB was positively associated with the total score for rumination (r ¼ .32, p < .01), deliberate rumination (r ¼ .75, p < .01), and confrontation (r ¼ .58, p < .01). The relationship between rumination and SWB was mediated by confrontation (indirect effect ¼ .74). Conclusion: BC diagnosis can affect patient's SWB. These findings indicate that rumination and confrontation have direct and indirect effects on SWB. Therefore, psychological interventions focused on improving coping may increase SWB. Notwithstanding, larger longitudinal studies are needed to further examine the relationship between cognitive processes, coping strategies, and SWB.

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“…Studies elucidated that breast cancer chemotherapy impairs cognitive functions 61 such as problems with memory, attention, processing speed, and executive functioning. 3 And fatigue (B=−20.385, P≤0.001) was the only non-hematological toxicity that negatively associated with impairment of cognitive functioning among our study participants. As it was explained above, the social functioning of our study participants persistently decreased from baseline to the end of the chemotherapy course.…”

Section: Discussionmentioning

confidence: 68%

“… 1 , 2 As such, there is a need to understand the impact of breast cancer treatment on quality of life (QoL) to help breast cancer patients cope with cancer and its treatment. 3 It is due to the quality of life is frequently deteriorated during and after cancer chemotherapy, though the expected treatment outcome in chronic diseases like cancer is the improvement of quality of life. 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

The Impact of AC and AC-T Chemotherapy’s Toxicities on Quality of Life Among Women with Breast Cancer in Ethiopia: A Prospective Patient-Reported Outcomes Study

Gadisa

Wang

Yimer

2021

BCTT

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Purpose The study aimed to evaluate the quality of life patterns and the effects of AC and AC-T chemotherapy’s toxicities on QoL among Ethiopian women with breast cancer. Methods QoL was measured at baseline and at every end of two cycles, for the median of 8 cycles among 146 breast cancer women on AC and AC-T chemotherapy, using EORTC QLQ-C30 and BR23 instruments. The effect of QoL score, socio-demographic, and clinical variables at baseline were adjusted for the effect of chemotherapy’s toxicities on QoL. Results Overall QoL, all functional scales (except cognitive functioning, body image, future perspectives, and sexual functioning) and symptom scales (except dyspnea, insomnia, pain score, arm, and breast symptoms) of EORTC QLQ-C30 and BR23 deteriorated significantly both clinically and statistically, in particular, during the first two cycles of chemotherapy. After the end of cycle 2 or 4, except for cognitive, social functioning, and financial difficulties of the patients, almost all other QoL dimensions were improved towards pretreatment score by the end of cycle 8. In addition to age, educational status, and tumor stage, the Global Health Status (−10.55≤B≤−7.71, P≤0.013), and the functional scales (−25.320≤B≤−6.351, P≤0.033) of EORTC QLQ-C30 and BR23 were significantly affected at least by one of the AC and AC-T chemotherapy’s toxicity such as grade≥2 fatigue, dysgeusia, constipation, dry mouth, vomiting, oral mucositis, skin hyperpigmentation and/or peripheral neuropathy than their lower grade. Grade≥2 fatigue, dysgeusia, oral mucositis, constipation, peripheral neuropathy, anemia arthralgia/myalgia, dry mouth, diarrhea, constipation, and/or skin hyperpigmentation were positively predicted for the deterioration of symptoms scale of EORTC QLQ-C30 and BR23 (4.819≤B≤26.451, P≤0.043). Conclusion Quality of life among Ethiopian breast cancer patients on AC and AC-T regimens significantly deteriorated particularly during the first two cycles of chemotherapy. In addition to the age, tumor stage and educational status of the patients, grade≥2 fatigue, dysgeusia, constipation, oral mucositis, dry mouth, peripheral neuropathy, and skin hyperpigmentation due to AC and AC-T chemotherapy were frequently associated with deterioration of different scales/items QoL. Hence, devising different strategies to improve the deteriorated QoL due to chemotherapy’s toxicities particularly during the first two cycles has paramount importance.

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The role of depression in the relationship between cognitive decline and quality of life among breast cancer patients

Cited by 32 publications

References 28 publications

The effect of fear of progression on quality of life among breast cancer patients: the mediating role of social support

The effect of fear of progression on quality of life among breast cancer patients: the mediating role of social support

The Relationship Among Rumination, Coping Strategies, and Subjective Well-being in Chinese Patients With Breast Cancer: A Cross-sectional study

The Impact of AC and AC-T Chemotherapy’s Toxicities on Quality of Life Among Women with Breast Cancer in Ethiopia: A Prospective Patient-Reported Outcomes Study

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