The role of Cutibacterium acnes in auto-inflammatory bone disorders

Zimmermann, Petra; Curtis, Nigel

doi:10.1007/s00431-018-3263-2

Cited by 32 publications

(21 citation statements)

References 38 publications

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“…However, in individual cases, Propionibacterium/Cutibacterium acnes may be present, which complicates the diagnosis as they may represent contamination [ 5 , 33 ]. Thus, a clinical dilemma exists as acute or chronic bacterial osteomyelitis may not exhibit high inflammatory parameters, especially when low-virulent strains of bacteria are present, such as Propionibacteriae [ 34 , 35 ].…”

Section: The Role Of Histopathology and Microbiologymentioning

confidence: 99%

New Insights into Adult and Paediatric Chronic Non-bacterial Osteomyelitis CNO

Hedrich

Morbach

Reiser³

et al. 2020

Curr Rheumatol Rep

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Purpose of Review To describe in detail the clinical synopsis and pathophysiology of chronic non-bacterial osteomyelitis and SAPHO syndrome. Recent Findings Chronic non-bacterial osteomyelitis (CNO) has been identified as a disease entity for almost 50 years. This inflammatory bone disorder is characterized by osteolytic as well as hyperostotic/osteosclerotic lesions. It is chronic in nature, but it can present with episodic flairs and phases of remission, which have led to the denomination “chronic recurrent osteomyelitis”, with its severe multifocal form “chronic recurrent multifocal osteomyelitis” (CRMO). For almost three decades, an infectious aetiology had been considered, since especially Propionibacterium acnes had been isolated from bone lesions of individual patients. However, this concept has been challenged since long-term antibiotic therapy did not alter the course of disease and modern microbiological techniques (including PCR) failed to confirm bone infection as an underlying cause. Over recent years, a profound dysregulation of cytokine expression profiles has been demonstrated in innate immune cells of CNO patients. A hallmark of monocytes from CNO patients is the failure to produce immune regulatory cytokines interleukin-10 (IL-10) and IL-19, which have been linked with genetic and epigenetic alterations. Subsequently, a significant upregulation of pro-inflammatory, NLRP3 inflammasome-dependent cytokines (IL-1β and TNF-α), has been demonstrated. Summary The current knowledge on CNO, the underlying molecular pathophysiology, and modern imaging strategies are summarized; differential diagnoses, treatment options, outcome measures, as well as quality of life studies are discussed.

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Section: The Role Of Histopathology and Microbiologymentioning

confidence: 99%

New Insights into Adult and Paediatric Chronic Non-bacterial Osteomyelitis CNO

Hedrich

Morbach

Reiser³

et al. 2020

Curr Rheumatol Rep

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“…Although the etiology is considered to be autoinflammatory, Cutibacterium acnes infection may activate the process in some cases. Cultures are usually negative, and biopsy shows sterile, nonspecific osteitis without sequestrum formation [151]. SAPHO has been associated with axial spondyloarthropathy and CRMO, a childhood variant of chronic nonbacterial osteomyelitis (CNO) [152].…”

Section: Sapho Syndromementioning

confidence: 99%

Glossary of terms for musculoskeletal radiology

et al. 2020

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Members of the International Skeletal Society compiled a glossary of terms for musculoskeletal radiology. The authors also represent national radiology or pathology societies in Asia, Australia, Europe, and the USA. We provide brief descriptions of musculoskeletal structures, disease processes, and syndromes and address their imaging features. Given the abundance of musculoskeletal disorders and derangements, we chose to omit most terms relating to neoplasm, spine, intervention, and pediatrics. Consensus agreement was obtained from 19 musculoskeletal radiology societies worldwide.

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“…Osteoarticular lesions associated with SAPHO syndrome are most frequently found on the anterior chest wall (63%) [ 2 ], and skull involvement is rare. Although SAPHO syndrome is characterized by aseptic inflammation of the bone joint, Cutibacterium acnes ( C.ances ) may be involved in the pathology of SAPHO syndrome, and a few cases of C. acnes have reportedly been detected in SAPHO syndrome bone cultures [ 3 ]. In this letter, we report a case of SAPHO syndrome, in which the lesions were limited to the skull and C. acnes was detected after 10 days of skull bone culture.…”

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confidence: 99%

“…Cutibacterium acnes is a Gram-positive, anaerobic bacterium that is a normal component of the flora found in the mucous membranes and skin and is involved in the development of acne [ 7 ]. The detection of C. acnes in culture can easily be influenced by the culturing environment and requires a long-term culture of ∼10 days [ 3 ]. Although the aetiology of SAPHO syndrome has not been clarified, infections, such as C. acnes , have previously been associated with the aetiology of SAPHO syndrome.…”

mentioning

confidence: 99%

“…Although the aetiology of SAPHO syndrome has not been clarified, infections, such as C. acnes , have previously been associated with the aetiology of SAPHO syndrome. Some cases have reported the detection of C. acnes in bone cultures derived from patients with SAPHO syndrome or related diseases [ 3 , 7 ]. One study reported that SAPHO syndrome bone cultures were positive for C. acnes in 14 out of 21 patients, and antibiotic treatments reduced mean osteitis scores among these patients [ 8 ], suggesting the potential usefulness of antimicrobial treatments for patients who are positive for C. acnes .…”

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confidence: 99%

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