The role of CUGBP1 in age-dependent changes of liver functions

Jones, Karlie; Timchenko, Lubov; Timchenko, Nikolai A.

doi:10.1016/j.arr.2012.02.007

Cited by 34 publications

(32 citation statements)

References 78 publications

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“…Studies with young and old mice suggested that the phosphorylation of C/EBP␣ at S193 is the major pathway of regulation of interactions of C/EBP␣ with HDAC1 (14). In agreement with these observations, generation of C/EBP␣-S193D mice (further called S193D mice) showed that young S193D mice have increased amounts of HDAC1-C/EBP␣ complexes and have developed liver dysfunctions that are typically observed in old mice (6).…”

supporting

confidence: 68%

“…Two members of C/EBP family, C/EBP␣ and C/EBP␤, are expressed at high levels in the liver and are involved in the epigenetic control of liver proliferation and steatosis by interacting with p300 and HDAC1 (13)(14)(15). Studies with young and old mice suggested that the phosphorylation of C/EBP␣ at S193 is the major pathway of regulation of interactions of C/EBP␣ with HDAC1 (14).…”

mentioning

confidence: 99%

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Age-associated Change of C/EBP Family Proteins Causes Severe Liver Injury and Acceleration of Liver Proliferation after CCl4 Treatments

Hong

Lewis

Iakova

et al. 2014

Journal of Biological Chemistry

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Background: Older patients are more sensitive to drug-mediated development of liver disorders. Results: Age and CCl 4 treatments change expression of C/EBP proteins leading to repression of key regulators of liver biology. Conclusion:The age-associated alterations of C/EBP proteins cause severe liver injury after CCl 4 treatments. Significance: Understanding of mechanisms of age-associated severe liver injury is important for development of therapeutic approaches.

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supporting

confidence: 68%

mentioning

confidence: 99%

Age-associated Change of C/EBP Family Proteins Causes Severe Liver Injury and Acceleration of Liver Proliferation after CCl4 Treatments

Hong

Lewis

Iakova

et al. 2014

Journal of Biological Chemistry

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“…It is reported that Cugbp1‐mediated translational elevation of Hdac1 is one of the key events conducing to epigenetic changes in the liver of old mice, which lead to the development of age‐associated dysfunction of the liver [reviewed in Jones et al . (2012)]. Elevated activity of these miRNAs in df/df mice may therefore contribute to reduce systemic inflammation and improve health span.…”

Section: Discussionmentioning

confidence: 99%

Circulating microRNA signature of genotype‐by‐age interactions in the long‐lived Ames dwarf mouse

et al. 2015

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SummaryRecent evidence demonstrates that serum levels of specific miRNAs significantly change with age. The ability of circulating sncRNAs to act as signaling molecules and regulate a broad spectrum of cellular functions implicates them as key players in the aging process. To discover circulating sncRNAs that impact aging in the long‐lived Ames dwarf mice, we conducted deep sequencing of small RNAs extracted from serum of young and old mice. Our analysis showed genotype‐specific changes in the circulating levels of 21 miRNAs during aging [genotype‐by‐age interaction (GbA)]. Genotype‐by‐age miRNAs showed four distinct expression patterns and significant overtargeting of transcripts involved in age‐related processes. Functional enrichment analysis of putative and validated miRNA targets highlighted cellular processes such as tumor suppression, anti‐inflammatory response, and modulation of Wnt, insulin, mTOR, and MAPK signaling pathways, among others. The comparative analysis of circulating GbA miRNAs in Ames mice with circulating miRNAs modulated by calorie restriction (CR) in another long‐lived mouse suggests CR‐like and CR‐independent mechanisms contributing to longevity in the Ames mouse. In conclusion, we showed for the first time a signature of circulating miRNAs modulated by age in the long‐lived Ames mouse.

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“…FUBP3 and XRN2 are the exceptions that do not encode an RNA-recognition motif and instead have either an hnRNP-K-homology domain or a CCHCtype zinc-finger motif that mediate RNA binding, respectively. Importantly, the identified RBPs have known established functions in the regulation of gene expression and they affect ARTICLE transcription, mRNA stability, translational regulation, mRNA processing and more [28][29][30][31][32][33] .…”

Section: Resultsmentioning

confidence: 99%

“…Our approach identified six novel MICB regulators; five negative regulators: FUBP3, HuR, XRN2, MATR3 and CUGBP1; as well as one positive regulator, IGF2BP2-short. The MICBregulating RBPs identified in the current study include wellknown RBPs with already established roles in well-known pathologies functioning as regulators of additional genes; HuR in cancer, metastasis and angiogenesis 44 , CUGBP1 in muscle pathologies 45,46 and liver dysfunction 29 and IGF2BP2 is implicated in the aetiology of late onset of type-2 diabetes 47 .…”

Section: Discussionmentioning

confidence: 99%

RNA-binding proteins regulate the expression of the immune activating ligand MICB

et al. 2014

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The recognition of stress-induced ligands by the activating receptor NKG2D expressed on cytotoxic lymphocytes is crucial for the prevention and containment of various diseases and is also one of the best-studied examples of how danger is sensed by the immune system. Still, however, the mechanisms leading to the expression of the NKG2D ligands are far from being completely understood. Here, we use an unbiased and systematic RNA pull-down approach combined with mass spectrometry to identify six RNA-binding proteins (RBPs) that bind and regulate the expression of MICB, one of the major stress-induced ligands of NKG2D. We further demonstrate that at least two of the identified RBPs function during genotoxic stress. Our data provide insights into stress recognition and hopefully open new therapeutic venues.

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The role of CUGBP1 in age-dependent changes of liver functions

Cited by 34 publications

References 78 publications

Age-associated Change of C/EBP Family Proteins Causes Severe Liver Injury and Acceleration of Liver Proliferation after CCl4 Treatments

Age-associated Change of C/EBP Family Proteins Causes Severe Liver Injury and Acceleration of Liver Proliferation after CCl4 Treatments

Circulating microRNA signature of genotype‐by‐age interactions in the long‐lived Ames dwarf mouse

RNA-binding proteins regulate the expression of the immune activating ligand MICB

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