RNA-binding proteins regulate the expression of the immune activating ligand MICB

Nachmani, Daphna; Gutschner, Tony; Reches, Adi; Diederichs, Sven; Mandelboim, Ofer

doi:10.1038/ncomms5186

Cited by 26 publications

(25 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RBPs can have a major impact on the half-life of lncRNA and mRNA molecules. 47,48 Recruitment of the RBP ELAVL1 to CTNNB1, mediated via the lncRNA UFC1, stabilizes CTNNB1 levels in the cytoplasm and increases levels of CTNNB1 in the nucleus. 14 Similar to DANCR and UFC1, the lncRNA lnc-betacatm functions via a CTNNB1 stabilization mechanism.…”

Section: Selected Functions and Molecular Mechanisms Of Ncrnas In Hccmentioning

confidence: 99%

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

Klingenberg

Matsuda

Diederichs

et al. 2017

Journal of Hepatology

Self Cite

306

269

View full text Add to dashboard Cite

show abstract

Section: Selected Functions and Molecular Mechanisms Of Ncrnas In Hccmentioning

confidence: 99%

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

Klingenberg

Matsuda

Diederichs

et al. 2017

Journal of Hepatology

Self Cite

306

269

View full text Add to dashboard Cite

show abstract

“…In addition, US18 and US20 target MICA for lysosomal degradation [10]. Finally, the viral miRNA miR-UL112 acts in synergy with cellular miRNAs to inhibit MICB expression in CMV-infected cells [11], and MICA expression is regulated by at least two RNA-binding proteins [12]. …”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus-Infected Primary Endothelial Cells Trigger NKG2C<sup>+</sup> Natural Killer Cells

et al. 2016

View full text Add to dashboard Cite

Among innate cells, natural killer (NK) cells play a crucial role in the defense against cytomegalovirus (CMV). In some individuals, CMV infection induces the expansion of NKG2C⁺ NK cells that persist after control of the infection. We have previously shown that KIR2DL⁺ NK cells, in contrast to NKG2C⁺ NK cells, contribute to controlling CMV infection using a CMV-infected monocyte-derived dendritic cell (MDDC) model. However, the nature of CMV-infected cells contributing to the expansion of the NKG2C⁺ NK cell subset remains unclear. To gain more insight into this question, we investigated the contribution of NKG2C⁺ NK cell activation by CMV-infected primary human aortic endothelial cells (EC) isolated from kidney transplant donors, which constitutively express the human leukocyte antigen (HLA)-E molecule. Here, we show that, although classic HLA class I expression was drastically downregulated, nonclassic HLA-E expression was maintained in CMV-infected EC. By comparing HLA expression patterns in CMV-infected EC, fibroblasts and MDDC, we demonstrate a cell-dependent modulation of HLA-E expression by CMV infection. NKG2C⁺ NK cell degranulation was significantly triggered by CMV-infected EC regardless of the nature of the HLA-E allele product. EC, predominantly present in vessels, may constitute a privileged site for CMV infection that drives a ‘memory' NKG2C⁺ NK cell subset.

show abstract

“…RBPs play a part in every aspect of RNA biogenesis, including transcription, pre-mRNA splicing, polyadenylation, RNA modification, transport, localization, translation, turnover, and immune activities (11)(12)(13)(14)(15). One major family of RBPs is the heterogeneous nuclear ribonucleoproteins (HNRNPs), which are among the most abundant proteins in the eukaryotic nucleus, taking part in processing of precursor mRNA (16).…”

mentioning

confidence: 99%

HNRNPR Regulates the Expression of Classical and Nonclassical MHC Class I Proteins

Reches¹,

Nachmani²,

Berhani³

et al. 2016

The Journal of Immunology

Self Cite

View full text Add to dashboard Cite

MHC class I molecules, in addition to their role in specific activation of the CTL of adaptive immune system, function also as the main ligands for NK cell inhibitory receptors, which prevent NK cells from killing normal, healthy cells. MHC class I proteins are divided into classical and nonclassical proteins. The former group consists of hundreds of HLA-A, B, and C alleles, which are universally expressed, whereas several alleles of the latter group, such as HLA-G, manifest a restricted expression pattern. Despite the important role played by these molecules in innate and adaptive immune responses, their complex expression regulation is not fully known. In our study, we investigated the regulation processes controlling the expression of MHC class I molecules, with a particular focus on their 3′ untranslated regions. We identified heterogeneous nuclear ribonucleoprotein R (HNRNPR) as an important positive regulator of classical and nonclassical MHC class I molecules. HNRNPR is a RNA-binding protein belonging to the heterogeneous nuclear ribonucleoprotein family, which has a known role in processing of precursor mRNA. We demonstrated that HNRNPR binds MHC class I mRNAs in their 3′ untranslated regions and enhances their stability and consequently their expression. Furthermore, regulation by HNRNPR modulates the cytotoxic activity of NK cells. In conclusion, we show that HNRNPR acts as a general positive regulator of MHC class I expression.

show abstract

RNA-binding proteins regulate the expression of the immune activating ligand MICB

Cited by 26 publications

References 51 publications

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

Cytomegalovirus-Infected Primary Endothelial Cells Trigger NKG2C<sup>+</sup> Natural Killer Cells

HNRNPR Regulates the Expression of Classical and Nonclassical MHC Class I Proteins

Contact Info

Product

Resources

About