The role of complement in biomaterial-induced inflammation

Nilsson, Bo; Ekdahl, Kristina Nilsson; Mollnes, Tom Eirik; Lambris, John D.

doi:10.1016/j.molimm.2006.06.020

Cited by 381 publications

(313 citation statements)

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“…the immune and inflammatory response. Generally, hydrophilic surfaces induce milder responses compared to the ones set by hydrophobic surfaces [47]. Despite the experimental limitations resultant from measuring the contact angle in a powder material, both samples were found to be hydrophilic.…”

Section: Accepted M Manuscriptmentioning

confidence: 89%

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

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Cabrita

et al. 2013

Materials Science and Engineering: C

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Two commercial bone grafts used in dentistry (Osteobiol Gen-Os®, a xenograft of porcine origin, and Bonelike®, a hydroxyapatite based synthetic material), in the form of granules, were characterized and evaluated in vivo regarding the intensity of the tissue inflammatory response. These biomaterials were characterized in terms of morphology, particle size distribution, porosity and pore size, specific surface are and density. The chemical composition and structure of the materials were accessed by Fourier-Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD). The graft materials were implanted in the gluteus maximus muscles of Wistar rats and the inflammatory response evaluated through histological analysis, after one week of implantation.The results showed that the two grafts have quite different characteristics in practically all the evaluated properties. While Osteobiol® exhibits a structure and composition similar to the natural bone, Bonelike® is constituted by a main crystalline phase of hydroxyapatite and two secondary phases of -and -tricalcium phosphate. Osteobiol® granules, besides being larger, are irregular, and exhibit sharp-edged tips, while those of Bonelike® are approximately cylindrical, with round contours, and more uniform in size. The in vivo response evaluated from the inflammatory infiltrates revealed that although both implants did not cause severe inflammation, Bonelike® granules elicit a consistently more intense inflammatory reaction than that triggered by the granules of Osteobiol®, particularly in terms of collagen production and formation of fibrous capsule. This reaction was partly explained in terms of the characteristics evaluated for the granules of this material.

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Section: Accepted M Manuscriptmentioning

confidence: 89%

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Figueiredo

Coimbra

Cabrita

et al. 2013

Materials Science and Engineering: C

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“…The activation of the complement system is one of the most significant challenges when blood is exposed to foreign materials 16, 17, 18, 19. Measures of C3a and SC5b‐9, also called Terminal Complement Complex (TCC), are widely used as complement activation markers.…”

Section: Methodsmentioning

confidence: 99%

Improved ex vivo blood compatibility of central venous catheter with noble metal alloy coating

et al. 2015

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Central line associated bloodstream infections (CLABSIs) are a serious cause of morbidity and mortality induced by the use of central venous catheters (CVCs). Nobel metal alloy (NMA) coating is an advanced surface modification that prevents microbial adhesion and growth on catheters and thereby reduces the risk of infection. In vitro microbiological analyses have shown up to 90% reduction in microbial adhesion on coated CVC compared to uncoated ones. This study aimed to assess the blood compatibility of NMA‐coated CVC according to ISO 10993‐4. Hemolysis, thrombin–antithrombin (TAT) complex, platelet counts, fibrin deposition, and C3a and SC5b‐9 complement activation were analyzed in human blood exposed to the NMA‐coated and control CVCs using a Chandler‐loop model. NMA‐coated CVC did not induce hemolysis and fell in the “nonhemolytic” category according to ASTM F756‐00. Significantly lower amounts of TAT were generated and less fibrin was deposited on NMA‐coated CVC than on uncoated ones. Slightly higher platelet counts and lower complement markers were observed for NMA‐coated CVC compared to uncoated ones. These data suggest that the NMA‐coated CVC has better ex vivo blood compatibility compared to uncoated CVC. © 2015 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1359–1365, 2016.

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“…The formed thiolate acts as a base and catalyzes the transfer of the acyl group to hydroxyl groups, prototypically located on carbohydrate residues that coat pathogens 27 . This mechanism also occurs with some nonnatural hydroxlyated material surfaces 28,29 , including Pluronic-coated materials 30 . Biomaterials scientists have typically sought to avoid complement activation in order to minimize effects such as implant rejection and clearance of systemic drug delivery vehicles.…”

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confidence: 94%

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

et al. 2007

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The role of complement in biomaterial-induced inflammation

Cited by 381 publications

References 100 publications

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Improved ex vivo blood compatibility of central venous catheter with noble metal alloy coating

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

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