The Role of Combination Calcipotriol plus Betamethasone Dipropionate Gel in the Treatment of Moderate-to-Severe Scalp Seborrhoeic Dermatitis

Yap, Felix Boon-Bin

doi:10.18295/squmj.2018.18.04.015

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…is study showed that the combination of betamethasone Dermatology Research and Practice and calcipotriol is useful in the treatment of moderate to severe scalp disease. However, the study was quasi-experimental and retrospective [20]. e observed discrepancy between studies can be due to variable experimental design, unknown status of basal serum 25(OH)D level, and disease severity.…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of 25-Hydroxyvitamin D in Patients with Seborrheic Dermatitis: A Case-Control Study

Rahimi

Nemati

Shafaei-Tonekaboni

2021

Dermatology Research and Practice

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Several autoimmune papulosquamous skin conditions such as psoriasis, systemic lupus erythematous, and lichen planus have been associated with vitamin D deficiency or correlated with serum vitamin D level. This study was aimed at comparing the 25-hydroxyvitamin D (25(OH)D) status in patients with facial or scalp seborrheic dermatitis with healthy subjects. This case-control study included 289 patients (118 with psoriasis and 171 sex- and age-matched control subjects) from the outpatient clinic of two hospital dermatology departments in the west of Mazandaran province, Iran. All patients and control subjects were studied during one season to avoid seasonal variations in vitamin D levels. Serum mean ± standard deviation of 25(OH)D levels were signiﬁcantly lower in seborrheic dermatitis patients than in control subjects (20.71 ± 8.16 vs. 23.91 ± 7.78, P = 0.007). Serum 25(OH)D levels were negatively associated with the risk of developing seborrheic dermatitis (odds ratio (OR): 0.898, 95% confidence interval (Cl): 0.840–0.960, P = 0.002). Also, vitamin D under 30 ng/ml was associated with OR: 4.22 (95% Cl: 1.077–16.534, P = 0.039) for seborrheic dermatitis. The severity of scalp disease was significantly associated with serum 25(OH)D level ( P = 0.003). Cases with severe scalp scores had significantly lower serum 25(OH)D level compared to moderate OR score ( P = 0.036). A similar trend was not seen in the facial disease. The 25(OH)D values are signiﬁcantly lower in seborrheic dermatitis patients than in healthy subjects. Furthermore, the scalp disease severity was associated with lower serum 25(OH)D level. Our results may suggest that vitamin D may play a role in the pathogenesis of seborrheic dermatitis.

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Section: Discussionmentioning

confidence: 99%

Serum Levels of 25-Hydroxyvitamin D in Patients with Seborrheic Dermatitis: A Case-Control Study

Rahimi

Nemati

Shafaei-Tonekaboni

2021

Dermatology Research and Practice

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“…The data in studies on the use of topical vit D analogs in the treatment of SD are still contradictory. While beneficial results are obtained in some studies, others are not found to be effective enough 32 - 37 .…”

Section: Discussionmentioning

confidence: 99%

Vitamin D levels in patients with seborrheic dermatitis

Akbaş

Kılınç

Şener

et al. 2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: Seborrheic dermatitis is a common papulosquamous skin disease with unknown pathogenesis. The aim of our study was to determine the serum level of 25-hydroxy vitamin D in patients with seborrheic dermatitis SD. METHODS: A total of 53 patients and 60 healthy controls were included in the study. Serum vitamin D, calcium, phosphorus, and parathormone levels were measured in the patient and control groups, and a comparison was made between the two groups regarding these parameters. RESULTS: Severe vitamin D deficiency was more frequent among patients with seborrheic dermatitisSD compared to controls (52.8 vs. 25.8%, p=0.003). In patients with severe vitamin D deficiency, seborrheic dermatitis SD was detected more frequently at an early age (p=0048) and in women (p=0.015). No correlation was found between the seborrheic dermatitis skin involvement site and vitamin D level. CONCLUSION: The fact that vitamin D levels decreased in patients with seborrheic dermatitis SD and patients with severe vitamin D deficiency develop seborrheic dermatitis SD earlier suggests that the low levels of vitamin D are related to seborrheic dermatitis.

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“…In an early Japanese open trial, application of tacalcitol (1,24dihydroxycholecalciferol) twice daily produced a 73% marked improvement in facial SD [94]. Basak and Ergin [95] divided sixty patients into two equal groups and treated with either calcipotriol (50 µg/mL) or betamethasone 17-valerate (1 mg/mL) solution twice daily for four weeks. Although both treatments displayed successful results, the betamethasone 17-valerate treatment was superior to that of calcipotriol treatment in all aspects.…”

Section: Seborrheic Dermatitismentioning

confidence: 99%

Impact of vitamin D on ultraviolet-induced photoaging and skin diseases

Ambagaspitiya,

Appuhamillage,

Dassanayake

2024

Exploration of Medicine

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Excessive exposure to ultraviolet (UV) radiation causes premature aging of the skin, known as photoaging. UV radiation induces DNA damage, oxidative stress, inflammatory reactions, and degradation of extracellular matrix (ECM) proteins, contributing to the aged skin phenotype. The skin synthesizes vitamin D upon UVB exposure, which plays a pivotal role in the proper function of multiple body systems. Vitamin D protects skin from photo-damage by repairing cyclobutane pyrimidine dimers, reversing oxidative stress, and reducing chronic inflammation. Moreover, various epidemiological studies have identified vitamin D deficiency as a marker for common dermatological disorders. Improvement of clinical outcomes with vitamin D supplementation further suggests its protective role against skin pathologies. This review comprehensively covers the involvement of vitamin D in combating UV-induced photoaging and various skin disorders, highlighting the significance of maintaining vitamin D adequacy for healthy skin.

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The Role of Combination Calcipotriol plus Betamethasone Dipropionate Gel in the Treatment of Moderate-to-Severe Scalp Seborrhoeic Dermatitis

Cited by 3 publications

References 13 publications

Serum Levels of 25-Hydroxyvitamin D in Patients with Seborrheic Dermatitis: A Case-Control Study

Serum Levels of 25-Hydroxyvitamin D in Patients with Seborrheic Dermatitis: A Case-Control Study

Vitamin D levels in patients with seborrheic dermatitis

Impact of vitamin D on ultraviolet-induced photoaging and skin diseases

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