The Role of Clostridia in Diarrheal Diseases of Man

The Histotoxic Clostridial Infections of Man 12

“…It must also be mentioned here that human enteric infections with C. perfringens type D have been clearly demonstrated on at least two occasions (355,545). From an epidemiological standpoint such cases are to be regarded as no more than oddities, yet they do indicate that several more of the known types and, therefore, several more of the known toxins of C. perfringens are potentially of importance in human disease (642). As for C. perfringens type A, it will be seen from Tables 2 and 3 that this organism can elaborate a-, 0-, K-, A-, and v-toxins.…”

“…Because this organism is a constant inhabitant of the human gut, proof of its direct involvement in enteric disease has been extremely difficult. The more recent data, obtained for the most part within the past decade, make it clear that we have to deal not with a single new disease but with a number of 1962] on August 28, 2020 by guest http://mmbr.asm.org/ Downloaded from distinct syndromes, separable both clinically and bacteriologically (642).…”

The Histotoxic Clostridial Infections of Man

“…Because this organism is a constant inhabitant of the human gut, proof of its direct involvement in enteric disease has been extremely difficult. The more recent data, obtained for the most part within the past decade, make it clear that we have to deal not with a single new disease but with a number of 1962] on December 13, 2020 by guest http://mmbr.asm.org/ Downloaded from distinct syndromes, separable both clinically and bacteriologically (642).…”