The role of circadian rhythm in male reproduction

Peterlin, Ana; Kunej, Tanja; Peterlin, Borut

doi:10.1097/med.0000000000000512

Cited by 14 publications

(11 citation statements)

References 40 publications

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“…Cry1 was expressed in Sertoli cells, spermatogonia, spermatocytes and in the interstitium. These mice showed no phenotypic abnormalities, with similar serum and intratesticular testosterone levels to wild-type mice and normal Sertoli and Leydig cells [107]. However, there was an increased number of degenerated and apoptotic germ cells in the testis corresponding to lower epididymal sperm counts and testicular cell apoptosis.…”

Section: Clockmentioning

confidence: 82%

“…Going deeply, the rs1801260 polymorphism associates with normal seminal parameters, while rs3817444 associates with both normal and abnormal seminal parameters [126]. Another study within this population highlighted the connection between CLOCK gene polymorphism and semen quality in idiopathic infertility [107]. Heterozygotes and homozygotes males (TC and CC) for a C allele variant at rs3749474 show a significant reduction in seminal volume, compared to TT genotype, and in addition, CC homozygotes have also both significantly lower concentration and sperm motility.…”

Section: Bmal1 Polymorphism Rs2278tt749mentioning

confidence: 99%

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Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility

Sciarra

Franceschini

Campolo

et al. 2020

IJMS

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Infertility represents a growing health problem in industrialized countries. Thus, a greater understanding of the molecular networks involved in this disease could be critical for the development of new therapies. A recent finding revealed that circadian rhythmicity disruption is one of the main causes of poor reproductive outcome. The circadian clock system beats circadian rhythms and modulates several physiological functions such as the sleep-wake cycle, body temperature, heart rate, and hormones secretion, all of which enable the body to function in response to a 24 h cycle. This intricated machinery is driven by specific genes, called “clock genes” that fine-tune body homeostasis. Stress of modern lifestyle can determine changes in hormone secretion, favoring the onset of infertility-related conditions that might reflect disfunctions within the hypothalamic–pituitary–gonadal axis. Consequently, the loss of rhythmicity in the suprachiasmatic nuclei might affect pulsatile sexual hormones release. Herein, we provide an overview of the recent findings, in both animal models and humans, about how fertility is influenced by circadian rhythm. In addition, we explore the complex interaction among hormones, fertility and the circadian clock. A deeper analysis of these interactions might lead to novel insights that could ameliorate the therapeutic management of infertility and related disorders.

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Section: Clockmentioning

confidence: 82%

Section: Bmal1 Polymorphism Rs2278tt749mentioning

confidence: 99%

Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility

Sciarra

Franceschini

Campolo

et al. 2020

IJMS

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“…Due to the inconsistent results of these studies, we suggest that this relationship could be affected by the circadian system, which has been established to be important in mature sperm production process. [27][28][29][30] Inappropriate sleep habits disrupt the rhythmic expression of circadian genes, leading to adverse effects on the male reproductive system. 31,32 Since the circadian sleep-wake cycle is regulated by melatonin, endogenous circadian rhythm disorders could disrupt the cycle by deregulating the production of melatonin and cortisol.…”

Section: Discussionmentioning

confidence: 99%

<p>Association Between Sleep Quality and Semen Parameters and Reproductive Hormones: A Cross-Sectional Study in Zhejiang, China</p>

Du¹,

Yang²,

Chen³

et al. 2020

NSS

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Background: The effects of sleep duration on semen quality have been documented in many epidemiological studies. However, the association between sleep quality and semen parameters and reproductive hormones is still unclear. Patients Enrollment and Methods: We conducted a cross-sectional study among 970 outpatients from the Reproductive Medicine Center in Zhejiang, China between October 2017 and July 2019. All participants delivered a semen sample, underwent a physical examination, and answered a questionnaire to provide the following information: demographics, life habits, and sleep habits. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI). We first divided the patients into two groups according to sleep quality (good sleep: PQSI < 5 and poor sleep: PSQI ≥ 5). Then, we analyzed routine sperm parameters (semen volume, sperm total motility, progressive motility, sperm concentration, total sperm number, and normal sperm morphology) and reproductive hormones (folliclestimulating hormone, luteinizing hormone, estrogen, testosterone, and prolactin) of each group. Finally, we used multivariate linear regression analysis and Spearman correlation coefficients to examine the relationship between sleep quality (discrete variable or dichotomous variable) and sperm parameters, reproductive hormones. Results: A negative correlation was found between the general PSQI scores and several semen parameters: total motility (r= −0.187979, p< 0.001), progressive motility (r= −0.192902, p< 0.001), concentration (r= −0.167063, p< 0.001), total sperm number (r= −0.160008, p< 0.001), and normal sperm morphology (r= −0.124511, p< 0.001). However, there was no significant correlation between the semen volume, all reproductive hormones and the general PSQI scores. After adjusting for confounders, men with poor sleep had lower total motility (β= −9.287; 95% CI, −12.050, −6.523), progressive motility (β= −8.853; 95% CI, −11.526, −6.180), concentration (log scale, β= −0.131; 95% CI, −0.181, −0.082), total sperm number (log scale, β= −0.137; 95% CI, −0.189, −0.084), and normal sperm morphology (β= −1.195; 95% CI, −1.844, −0.547), but semen volume and all reproductive hormones were not markedly altered. Conclusion: Poor sleep quality might be related to impaired semen quality, but we found no evidence that poor sleep quality affects reproductive hormones.

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“…Unfortunately, direct investigation of shift work on sperm quality is difficult due to difficulties to ensure environmental standardization for individuals in human studies. Thus, currently, shift work is not convincingly associated with either semen parameters or testosterone levels so far (Peterlin et al 2019) and comprehensive epidemiological studies with large groups of men with appropriate controls for relevant confounders are needed. As with the circadian regulation of female reproductive biology, a summary of the animal and human studies for male reproductive biology are presented in Table 2.…”

Section: The Role Of Circadian System In Male Reproductive Biologymentioning

confidence: 99%

Chronodisruption: effects on reproduction, transgenerational health of offspring and epigenome

Satı

2020

Reproduction

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The circadian system regulates the daily temporal organization in behavior and physiology, including neuroendocrine rhythms and reproduction. Modern life, however, increasingly impacts this complex biological system. Due to limitations of working with human subjects exposed to shiftwork schedules, most chronoregulation research has used rodent models. Recent publications in these model systems have emphasized the negative effects of circadian rhythm disruption on both female and male reproductive systems and fertility. Additionally, there is growing concern about the long-term effects of circadian rhythm disruptions during pregnancy on human offspring and their descendants as circadian regulation during pregnancy can also alter epigenetic programing in offspring. However, to truly know if such concerns apply to humans will require retrospective and prospective human studies. Therefore, this review will highlight the latest available evidence regarding potential effects of chronodisruption on both female and male reproductive systems. Additionally, it presents a comprehensive summary of transgenerational and epigenetic effects on adult offspring that result from maternal chronodisruption.

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The role of circadian rhythm in male reproduction

Cited by 14 publications

References 40 publications

Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility

Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility

<p>Association Between Sleep Quality and Semen Parameters and Reproductive Hormones: A Cross-Sectional Study in Zhejiang, China</p>

Chronodisruption: effects on reproduction, transgenerational health of offspring and epigenome

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