Chronodisruption: effects on reproduction, transgenerational health of offspring and epigenome

Satı, Leyla

doi:10.1530/rep-20-0298

Cited by 5 publications

(6 citation statements)

References 123 publications

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“…The placenta exposes maternal melatonin to the fetus at daily rhythmic intervals, with low concentrations during the day and high concentrations at night ( 8 ). Disrupting this rhythm during pregnancy may lead to detrimental outcomes for the mother and the growing fetus in utero and in adult life ( 8 , 56 , 61 , 73 ). The development of the embryo, uterine implantation, placentation, and delivery may be regulated by the clock molecular machinery in the circadian rhythm ( 73 ).…”

Section: Melatonin In the Placentamentioning

confidence: 99%

“…Disrupting this rhythm during pregnancy may lead to detrimental outcomes for the mother and the growing fetus in utero and in adult life ( 8 , 56 , 61 , 73 ). The development of the embryo, uterine implantation, placentation, and delivery may be regulated by the clock molecular machinery in the circadian rhythm ( 73 ). Circadian disruption or chronodisruption in pregnant women can lead to adverse outcomes in the offspring ( 61 ).…”

Section: Melatonin In the Placentamentioning

confidence: 99%

“…The circadian rhythm and CLOCK genes are essential in regulating the reproductive system ( 73 , 133 ) and parturition ( 56 ). Misalignment of this rhythm (chronodisruption) can adversely affect reproductive function and birthing outcomes ( 73 ).…”

Section: Viral Infections During Pregnancymentioning

confidence: 99%

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Melatonin: the placental antioxidant and anti-inflammatory

Joseph,

Schuch,

Hossack

et al. 2024

Front. Immunol.

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Melatonin (N-acetyl-5-methoxytryptamine) is an indolamine hormone with many physiological and biological roles. Melatonin is an antioxidant, anti-inflammatory, free radical scavenger, circadian rhythm regulator, and sleep hormone. However, its most popular role is the ability to regulate sleep through the circadian rhythm. Interestingly, recent studies have shown that melatonin is an important and essential hormone during pregnancy, specifically in the placenta. This is primarily due to the placenta’s ability to synthesize its own melatonin rather than depending on the pineal gland. During pregnancy, melatonin acts as an antioxidant and anti-inflammatory, which is necessary to ensure a stable environment for both the mother and the fetus. It is an essential antioxidant in the placenta because it reduces oxidative stress by constantly scavenging for free radicals, i.e., maintain the placenta’s integrity. In a healthy pregnancy, the maternal immune system is constantly altered to accommodate the needs of the growing fetus, and melatonin acts as a key anti-inflammatory by regulating immune homeostasis during early and late gestation. This literature review aims to identify and summarize melatonin’s role as a powerful antioxidant and anti-inflammatory that reduces oxidative stress and inflammation to maintain a favorable homeostatic environment in the placenta throughout gestation.

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Section: Melatonin In the Placentamentioning

confidence: 99%

Section: Melatonin In the Placentamentioning

confidence: 99%

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Melatonin: the placental antioxidant and anti-inflammatory

Joseph,

Schuch,

Hossack

et al. 2024

Front. Immunol.

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“…Diurnal rhythms of sperm count, sperm motility, and sperm chromatin integrity have been found in rodents. There are also several studies which have investigated the diurnal variation of semen parameters in humans ( Ni et al, 2019 ; Sati, 2020 ). Variations in semen parameters were found across different time points in most of the studies, although a high-resolution sampling study is required to confidently profile the circadian pattern.…”

Section: Circadian Physiology In Major Organs Associated With Complex Diseasementioning

confidence: 99%

Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease

Xin

Yuan

et al. 2021

Front. Genet.

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The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles of environmental light. Fundamental mechanisms of how the circadian clock regulates organ physiology and metabolism have been elucidated at a rapid speed in the past two decades. Here we review circadian networks in more than six organ systems associated with complex disease, which cluster around metabolic disorders, and seek to propose critical regulatory molecules controlled by the circadian clock (named clock-controlled checkpoints) in the pathogenesis of complex disease. These include clock-controlled checkpoints such as circadian nuclear receptors in liver and muscle tissues, chemokines and adhesion molecules in the vasculature. Although the progress is encouraging, many gaps in the mechanisms remain unaddressed. Future studies should focus on devising time-dependent strategies for drug delivery and engagement in well-characterized organs such as the liver, and elucidating fundamental circadian biology in so far less characterized organ systems, including the heart, blood, peripheral neurons, and reproductive systems.

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“…Exclusion criteria included requirements for publication in English and operational definitions of shiftwork and/or nightshift, with a focus on primary research papers over meta-analyses. Additionally, the scope of this review includes reproductive and fertility measures up to birth, but does not focus on the long-term influence of shiftwork on offspring, although it should be noted that there is evidence that shiftwork can exert generational effects [81]. Within this review, shiftwork was defined as exposure to any combination of evening shifts, night shifts, and/or rotating shifts.…”

Section: Chronic Shiftwork Negatively Impacts Fertility In Women 21mentioning

confidence: 99%

Shiftwork and Light at Night Negatively Impact Molecular and Endocrine Timekeeping in the Female Reproductive Axis in Humans and Rodents

Yaw

McLane-Svoboda

Hoffmann

2020

IJMS

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Shiftwork, including work that takes place at night (nightshift) and/or rotates between day and nightshifts, plays an important role in our society, but is associated with decreased health, including reproductive dysfunction. One key factor in shiftwork, exposure to light at night, has been identified as a likely contributor to the underlying health risks associated with shiftwork. Light at night disrupts the behavioral and molecular circadian timekeeping system, which is important for coordinated timing of physiological processes, causing mistimed hormone release and impaired physiological functions. This review focuses on the impact of shiftwork on reproductive function and pregnancy in women and laboratory rodents and potential underlying molecular mechanisms. We summarize the negative impact of shiftwork on female fertility and compare these findings to studies in rodent models of light shifts. Light-shift rodent models recapitulate several aspects of reproductive dysfunction found in shift workers, and their comparison with human studies can enable a deeper understanding of physiological and hormonal responses to light shifts and the underlying molecular mechanisms that may lead to reproductive disruption in human shift workers. The contributions of human and rodent studies are essential to identify the origins of impaired fertility in women employed in shiftwork.

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Chronodisruption: effects on reproduction, transgenerational health of offspring and epigenome

Cited by 5 publications

References 123 publications

Melatonin: the placental antioxidant and anti-inflammatory

Melatonin: the placental antioxidant and anti-inflammatory

Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease

Shiftwork and Light at Night Negatively Impact Molecular and Endocrine Timekeeping in the Female Reproductive Axis in Humans and Rodents

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