The role of Chromium III  in the organism and its possible use in diabetes and obesity treatment

Lewicki, Sławomir; Zdanowski, Robert; Krzyżowska, Małgorzata; Lewicka, Aneta; Debski, Bogdan; Niemcewicz, Marcin; Goniewicz, Mariusz

doi:10.5604/1232-1966.1108599

Cited by 154 publications

(96 citation statements)

References 80 publications

(77 reference statements)

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“…Wyniki badań na zwierzętach wskazują na korzystne działanie organicznych i nieorganicznych związków chromu na gospodarkę węglowodanową i lipidową w ich organizmie (5,46,61,77,88), zwiększanie beztłuszczowej masy ciała oraz stężenia insuliny w surowicy, spadek śmiertelności (16,46,86,88).…”

Section: Chrom W żYwieniu Zwierząt I Ludziunclassified

“…Ujemny bilans Cr obserwowano u pacjentów cierpiących na cukrzycę typu I (54). Zwiększoną sekrecję tego pierwiastka z moczem stwierdzono także u szczurów po domię-śniowym podaniu insuliny (22,61).…”

Section: Toksykokinetykaunclassified

“…Natomiast Kabata-Pendias i Pendias (52) stwierdzają na podstawie wielu wyników badań, że najwięcej chromu występuje we włosach, skórze i zębach 0,2-1 mg·kg -1 , podczas gdy tkanki miękkie zawierają 0,02-0,1 mg·kg -1 . Wykazano, że niektóre tkanki, takie jak kości, jądra i najądrza, są zdolne do przechowywania Cr w sposób długotrwały w porównaniu do serca, trzustki i mózgu, gdzie usuwanie jonów chromu następuje stosunkowo szybko (61). Według Anke i wsp.…”

Section: Toksykokinetykaunclassified

“…(7) po podawaniu indykom CrCl 3 . U kur Cr podawany był w różnych formach (drożdże, pikolinian Cr, chlorek Cr) i powodował akumulację w wątrobie, nerkach i mięśniach bez wpływu na zawartość Cr w jajach (61,102). W przypadku badań Piva i wsp.…”

Section: Toksykokinetykaunclassified

“…Ponadto, metal ten pełni istotną funkcję w metabolizmie węglowodanów, białek i lipidów (5,13,18,43,46,61,68,85,86,99,101), zwłaszcza cholesterolu. Związki Cr (III) wchodzą w skład enzymów, kwasów rybonukleinowych, przyspieszają krzepnięcie krwi, zwiększają aktywność β-glukuronidazy (18).…”

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Trivalent chromium (CrIII) as a trace element essential for animals and humans

Kosla¹,

Lasocka²,

Skibniewska³

et al. 2018

Medycyna Weterynaryjna

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Trivalent chromium is considered an essential element in the nutrition of both animals and humans. Animal studies confirm many beneficial effects of organic and inorganic chromium compounds on carbohydrate, protein and lipid metabolism in the body. Glucose tolerance factor (GTF) has been demonstrated to involve an active form of trivalent chromium, which sustains normal glucose metabolism. Cr(III) compounds form enzymes and ribonucleic acids, accelerate blood clotting and increase β-glucuronidase activity. Chromium also participates in antioxidant processes, in the synthesis of RNA and DNA and in the immune response, as well as affects secretion of hormones and some vitamins. It has been demonstrated that chromium improves lean body mass in animals, increases growth rate and feed conversion and improves feed intake and energy efficiency. Organic chromium reduces mortality and improves animal reproduction parameters. It also enhances immunity and strengthens response to preventive vaccination. It has been noted in many animal species that a diet low in chromium leads to deficiency symptoms, such as reduced feed intake, lower weight gains, reproductive disorders and increased lipid levels. Chromium deficiency can also result from stress. Moderate chromium deficiency is a risk factor of ischemic heart disease with myocardial infarction. Such a condition may pose a great risk of coronary artery disease. Dietary chromium requirement of an animal body is probably 300 μg Cr/kg d.w. of feed, which is usually satisfied by the ration provided. The highest concentration of chromium is found in the hair, skin and teeth, followed by the liver, kidneys, spleen, and slightly lower in the heart, muscles, pancreas, lungs, bones and brain. Chromium absorption rates in the human intestine range between 0.5 and 2% of the daily intake of inorganic Cr forms, and from 25 to 30% of the element ingested as organic complexes. Clinical studies show that the kinetics of chromium excretion from the system are complex and can be described by a multi-range model, the half-life ranging from 13 min to 192 days. Dietary chromium nanocomposite supplementation (CrNano) used in pigs nutrition has significantly increased Cr content in the blood, longissimus muscle, heart, liver, kidneys, jejunum and ileum. Chromium nanocomposite supplementation acts more effectively on the tissues and, as a consequence, increases the accumulation of the element. .

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Section: Chrom W żYwieniu Zwierząt I Ludziunclassified

Section: Toksykokinetykaunclassified

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Trivalent chromium (CrIII) as a trace element essential for animals and humans

Kosla¹,

Lasocka²,

Skibniewska³

et al. 2018

Medycyna Weterynaryjna

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Ameliorative effect of a nano chromium metal–organic framework on experimental diabetic chronic kidney disease

Fakharzadeh

Kalanaky²,

Argani

et al. 2020

Drug Development Research

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Metal–Organic Frameworks (MOFs) are a new class of crystalline porous structures which can be used as a novel structure in diverse fields of medical science. Several studies have shown that chromium supplementation can be effective in amelioration of biochemical parameters of diabetes and its renal complications. Therefore, a chromium‐containing MOF (DIFc) was synthetized by nanochelating technology in the present study and then its effect on biochemical indices in diabetic rats was evaluated. Diabetes was induced by high‐fat diet consumption and streptozotocin (35 mg/kg) injection and then the treatment started 8 weeks after disease induction and continued for 8 weeks. The results showed that DIFc treatment decreased HOMA‐IR index, blood urea nitrogen, uric acid and malondialdehyde in plasma samples. This nano MOF also reduced albumin, malondialdehyde and 8‐isoprostane in urine specimen, while it increased creatinine clearance. In conclusion, DIFc MOF demonstrated promising results in the present study, indicating that it can be developed and evaluated in future investigations with the aim of designing a novel agent for management of diabetes and its renal complications.

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