The role of childhood abuse in HPA-axis reactivity in Social Anxiety Disorder: A pilot study

Elzinga, Bernet M.; Spinhoven, Philip; Berretty, Ed; Jong, Paula de; Roelofs, Karin

doi:10.1016/j.biopsycho.2009.09.006

Cited by 55 publications

(30 citation statements)

References 36 publications

(59 reference statements)

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“…Increased concentrations of cortisol in the saliva, urinary and plasma, as well as a deficiency in HPA feedback mechanism were found in patients with anxiety disorders (Mantella et al, 2008;Vreeburg et al, 2010). These high levels were also correlated with PTSD in humans (Elzinga et al, 2003(Elzinga et al, , 2010Heim et al, 2000), and with chronic stress in rodents (Surget et al, 2011). Exposure to chronic stress alters the structure and function of brain regions involved in the control of HPA axis responses to stress (Magarinosand and McEwen, 1995).…”

Section: Discussionmentioning

confidence: 90%

Anxiolytic effects of a novel herbal treatment in mice models of anxiety

et al. 2012

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Section: Discussionmentioning

confidence: 90%

Anxiolytic effects of a novel herbal treatment in mice models of anxiety

et al. 2012

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“…Childhood trauma has been of prime interest in HPA axis research, leading Elzinga et al (2010) to conduct a study investigating its effects in socially anxious patients. Participants in this study included those with: (i) SAD and a history of childhood abuse (n ¼9), (ii) SAD without a history of childhood abuse (n¼ 9), (iii) PTSD patients (n ¼ 16), and (iv) a group of healthy controls (n ¼16).…”

Section: Social Anxiety Disordermentioning

confidence: 99%

Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders

Furtado

Katzman

2015

Psychiatry Research

149

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“…Elzinga et al [99] found a significant association between a history of childhood abuse (emotional, physical or sexual abuse) and enhanced cortisol reactivity to a psychosocial stress task in patients with SP, although any difference in baseline cortisol levels has been reported between SP patients, PTSD patients and healthy controls (Table 4).…”

Section: Faravelli C Et Al Stress and Anxiety Disorders: A Reviewmentioning

confidence: 99%

“…However, several authors have hypothesized that HPA axis hyperactivity may link early stressful events to the development of SP [11,40,99] .…”

Section: Faravelli C Et Al Stress and Anxiety Disorders: A Reviewmentioning

confidence: 99%

Childhood stressful events, HPA axis and anxiety disorders

Faravelli

Sauro²,

Godini³

et al. 2012

WJP

140

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Anxiety disorders are among the most common of all mental disorders and their pathogenesis is a major topic in psychiatry, both for prevention and treatment. Early stressful life events and alterations of hypothalamic pituitary adrenal (HPA) axis function seem to have a significant role in the onset of anxiety. Existing data appear to support the mediating effect of the HPA axis between childhood traumata and posttraumatic stress disorder. Findings on the HPA axis activity at baseline and after stimuli in panic disordered patients are inconclusive, even if stressful life events may have a triggering function in the development of this disorder. Data on the relationship between stress, HPA axis functioning and obsessive-compulsive disorder (OCD) are scarce and discordant, but an increased activity of the HPA axis is reported in OCD patients. Moreover, normal basal cortisol levels and hyperresponsiveness of the adrenal cortex during a psychosocial stressor are observed in social phobics. Finally, abnormal HPA axis activity has also been observed in generalized anxiety disordered patients. While several hypothesis have attempted to explain these findings over time, currently the most widely accepted theory is that early stressful life events may provoke alterations of the stress response and thus of the HPA axis, that can endure during adulthood, predisposing individuals to develop psychopathology. All theories are reviewed and the authors conclude that childhood life events and HPA abnormalities may be specifically and transnosographically related to all anxiety disorders, as well as, more broadly, to all psychiatric disorders.

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The role of childhood abuse in HPA-axis reactivity in Social Anxiety Disorder: A pilot study

Cited by 55 publications

References 36 publications

Anxiolytic effects of a novel herbal treatment in mice models of anxiety

Anxiolytic effects of a novel herbal treatment in mice models of anxiety

Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders

Childhood stressful events, HPA axis and anxiety disorders

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