The Role of CCR7 in T _H 1 and T _H 2 Cell Localization and Delivery of B Cell Help in Vivo

Abstract

Subsets of murine CD4+ T cells localize to different areas of the spleen after adoptive transfer. Naïve and T helper 1 (TH1) cells, which express the chemokine receptor CCR7, are home to the periarteriolar lymphoid sheath, whereas activated TH2 cells, which lack CCR7, form rings at the periphery of the T cell zones near B cell follicles. Retroviral transduction of TH2 cells with CCR7 forces them to localize in a TH1-like pattern and inhibits their participation in B cell help in vivo but not in vitro. Thus, differential expression of chemokine receptors results in unique cellular migration patterns that are important for effective immune responses.

CD30 triggering by agonistic antibodies regulates CXCR4 expression and CXCL12 chemotactic activity in the cell line L540

“…11 Although there is no appreciable change in CXCL12 responsiveness from the cortex to the medulla, 58 a less intense medullary expression of CXCR4 has been reported 63 that may reflect the reduced density of lymphocytes there, 58,63 as a result of apoptotic events favored by CD30 stimulation in the medullary context. 10 CCR7 is preferentially expressed in transitional cells 57 and medullary CD30 ϩ cells. 11,58 Thus, synergistic effects of CXCL12 and CCL21 30 may be driven by CD30 stimulation during thymic differentiation.…”

“…54,58,59 The regulation of CXCR4 and CCR7 on CD30 ϩ cells is likely to provide signals for the homing of activated T cells to specific sites 28,29,31,60 to inhibit the delivery of B-cell help and the activity of cytolytic CD8 ϩ cell trafficking. 57 CD30 ϩ cancers either of hematologic 6 or nonhematologic lineage 12 have distinctive clinical features and localize to CXCL12-CCL21-rich tissues, including the lymph nodes, spleen, liver, bone marrow, lung, and brain, 4,30,61,62 with a diffusion pattern that may be conditioned by CD30-dependent regulation of CXCR4 and CCR7. 30 The thymic microenvironment is rich in CXCL12 ϩ CD153 ϩ epithelial cells and in CD30 ϩ CXCR4 ϩ T cells.…”

“…29,38 The CCR7-CCL21 system plays an important role in naive lymphocyte homing to secondary lymphoid organs, which is impaired by disruption of the CCR7 gene [54][55][56] and is required for typical lymphoid tissue localization of Th1-type lymphocytes. 56,57 Both CCR7 and CXCR4 participate in the recruitment of lymphocytes from blood, 30,54 but CXCR4 Ϫ lymphocytes develop and seed peripheral lymphoid tissues normally. 54,58,59 The regulation of CXCR4 and CCR7 on CD30 ϩ cells is likely to provide signals for the homing of activated T cells to specific sites 28,29,31,60 to inhibit the delivery of B-cell help and the activity of cytolytic CD8 ϩ cell trafficking.…”

Chemokine Expression Dynamics in Mycobacterial (Type-1) and Schistosomal (Type-2) Antigen-Elicited Pulmonary Granuloma Formation

“…Of these, SLC and ELC are reportedly involved in cellular migration patterns in lymphoid tissues [7][8][9][10][11][12] and SDF-␣ in vascular and cerebellar development and hematopoiesis. [67][68][69] The detected transcripts were possibly derived from endogenous lungassociated lymphoid tissues.…”

“…It is noteworthy that among these, SDF-1␣, ELC and SLC have been implicated in the physiological recirculation of lymphocytes to lymphoid tissues. [7][8][9][10][11][12] Because these CKs were not induced with inflammation, it suggested that CKs are functionally segregated.…”