The role of CAPE in PI3K/AKT/mTOR activation and oxidative stress on testis torsion

Dilber, Yagmur; İnan, Sevinç; Ercan, Gülinnaz; Şencan, Aydın

doi:10.1016/j.acthis.2015.11.004

Cited by 27 publications

(21 citation statements)

References 33 publications

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“…Prior studies have demonstrated that testicular torsion for 30 min – 1 hr followed by testicular detorsion for 1–4 hr is enough to cause I/R injury(Dilber, Inan, Ercan, & Sencan, ). Thus, we developed a rat experimental model in which the testis was rotated for 2 hr followed by 24 hr of detorsion to induce significant testicular I/R damage in left testes of the rats in order to evaluate the benefits of rosiglitazone application before detorsion was performed.…”

Section: Discussionmentioning

confidence: 99%

Protective influence of rosiglitazone against testicular ischaemia-reperfusion injury in rats

et al. 2018

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Testicular torsion is a urology urgent disease which causes testicular injury and potential sterility. In this study, we explored the protective influence of rosiglitazone on testicular ischaemia-reperfusion damage. There were 28 male Sprague Dawley rats in total, which were assigned randomly to four groups. Group A was blank control one; group B was testicular injury one; group C was rosiglitazone one; group D was rosiglitazone antagonist one. The testicles were counter-rotated after 2 hr and then underwent orchiectomy 24 hr later. We found that testicular tissue structure of rats was seriously damaged in groups B and D. However, group C had better testicular architecture. Similar findings were also shown for lipid peroxidation by evaluating the MDA activity (p < .05). Unlike group B or group D, the levels of inflammation by evaluating the MPO activity, the levels of TNF-a, IL-1 and IL-6 and the expressions of ICAM-1 were prominently lower in group C (p < .05) as well. So our researches demonstrated that rosiglitazone significantly decreased the amount of responsive oxygen radical and regulated inflammatory responses. Rosiglitazone had a protective influence against testicular ischaemia-reperfusion injury in rats and possibly depended on its anti-inflammatory and antioxidant traits.

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Section: Discussionmentioning

confidence: 99%

Protective influence of rosiglitazone against testicular ischaemia-reperfusion injury in rats

et al. 2018

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“…3,11 Detorsion of the testes is followed by reperfusion and oxygenation, characterized by an increase in free-oxygen radicals and reactive nitrogen radicals (such as NO). 2,18 These biochemical changes have toxic effects, such as lipid peroxidation, protein oxidation, and oxidative damage to DNA. MDA is an end product of lipid peroxidation and a marker of oxidative damage; its level increases in tissue exposed to I/R injury.…”

Section: Discussionmentioning

confidence: 99%

“…Testicular torsion is an acute clinical condition that occurs in male newborns, children, and adolescents. 1,2 If ischemia of the testes persists for > 6 hours, it may result in the loss of testicular function and infertility. 3 The underlying mechanisms that cause testicular injury are ischemia due to testicular torsion and reperfusion after detorsion.…”

Section: Introductionmentioning

confidence: 99%

“…Ischemic damage occurs initially and is exacerbated by subsequent reperfusion injury. [1][2][3] Following ischemia/reperfusion (I/R), overproduction of reactive oxygen species (ROS) and nitrogen species (RNS) is thought to be the major cause of testicular injury. ROS can lead to a decrease in glutathione (GSH) and an increase in the lipid peroxidation of the last product of the peroxidation process, malondialdehyde (MDA), eventually resulting in deterioration of membrane integrity and cell death.…”

Section: Introductionmentioning

confidence: 99%

“…ROS can lead to a decrease in glutathione (GSH) and an increase in the lipid peroxidation of the last product of the peroxidation process, malondialdehyde (MDA), eventually resulting in deterioration of membrane integrity and cell death. 1,2,4 Experimental studies have shown that spermatogonia and spermatocytes are the cells most sensitive to testicular ischemia. Various antioxidants have been used to decrease the impact of free-oxygen radicals.…”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Hypericum perforatum and Quercetin in a Rat Model of Ischemia/Reperfusion Injury of Testes

et al. 2017

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Thymoquinone protects human retinal pigment epithelial cells against hydrogen peroxide induced oxidative stress and apoptosis

Liang

Zhao

et al. 2018

J of Cellular Biochemistry

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Oxidative stress in retinal pigment epithelium (RPE) cells may contribute to the progression of age-related macular degeneration. Thymoquinone (TQ), an active component derived from Nigella sativa, possesses antioxidative effect. However, the role of TQ in RPE cells under oxidative stress condition remains unclear. The present study aimed to examine the protective effect of TQ against hydrogen peroxide (H 2 O 2 )-induced oxidative stress in human RPE cells. Our results showed that TQ improved the cell viability and apoptosis in H 2 O 2induced ARPE cells. We also found that the levels of reactive oxygen species and malondialdehyde induced by H 2 O 2 were reduced after the pretreatment of TQ. In addition, the inhibitory effect of H 2 O 2 on the glutathione (GSH) level and superoxide dismutase activity was markedly attenuated by TQ pretreatment. Moreover, TQ enhanced the activation of Nrf2/heme oxygenase 1 (HO-1) signaling pathway in H 2 O 2 -induced ARPE cells. Knockdown of Nrf2 abolished the protective effect of TQ on H 2 O 2 -induced oxidative damage. These results suggested that TQ protected ARPE cells from H 2 O 2 -induced oxidative stress and apoptosis via the Nrf2/HO-1 signaling pathway. K E Y W O R D S age-related macular degeneration (AMD), apoptosis, Nrf2/heme oxygenase 1 (HO-1) signaling pathway, oxidative stress, retinal pigment epithelium (RPE) cells, thymoquinone (TQ)

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The role of CAPE in PI3K/AKT/mTOR activation and oxidative stress on testis torsion

Cited by 27 publications

References 33 publications

Protective influence of rosiglitazone against testicular ischaemia-reperfusion injury in rats

Protective influence of rosiglitazone against testicular ischaemia-reperfusion injury in rats

Protective Effects of Hypericum perforatum and Quercetin in a Rat Model of Ischemia/Reperfusion Injury of Testes

Thymoquinone protects human retinal pigment epithelial cells against hydrogen peroxide induced oxidative stress and apoptosis

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