The role of cancer stem cells in pathogenesis of colorectal cancer

Szaryńska, Magdalena; Olejniczak, Agata; Kmieć, Zbigniew

doi:10.5604/17322693.1227897

Cited by 14 publications

(13 citation statements)

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“…Recently, tremendous effort has been made to better understand the mechanisms of CRC development and its metastasis. Current concepts revolve around stem cells [ 40 , 41 ], the role of innate immunity [ 42 , 43 ], and alterations in the microbiome [ 44 ]. Our observation that SexH receptors are expressed not only in CRC cells but, what is more important, also in CRC colonic patient samples sheds new light on this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer

et al. 2018

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BackgroundColorectal cancer (CRC) is a leading cause of death in the western world, and its incidence increases with patient age. It is also known that with age there occur changes in the levels of certain hormones, including an increase in the secretion of pituitary gonadotropins (PtGs) as a result of the loss of gonadal hormone feedback. We recently reported that functional PtG receptors are expressed in human lung cancer cells, rhabdomyosarcoma cells, and malignant hematopoietic stem cells.FindingsHere we report for the first time that the receptors for follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are expressed in primary tumor samples isolated from CRC patients as well as in the established human CRC cell lines HTC116 and HTB37. Moreover, we also report that PtGs stimulate chemotaxis, adhesion, and proliferation of these cell lines.ConclusionsOur results suggest that PtGs play an important and underappreciated role in CRC pathogenesis, and we call for further studies to better define their role in gastrointestinal malignancies and their direct effect on putative CRC cancer stem cells.

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Section: Discussionmentioning

confidence: 99%

A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer

et al. 2018

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“…Colorectal cancer (CRC) is the third most common malignant tumor in humans, and is also the most common malignant gastrointestinal tumor . Although considerable efforts have been made to clarify the etiology and pathogenesis of CRC, many questions remain unanswered . It is important to elucidate the molecular mechanisms of CRC tumorigenesis and progression to facilitate the development of effective treatments.…”

Section: Introductionmentioning

confidence: 99%

“…1 Although considerable efforts have been made to clarify the etiology and pathogenesis of CRC, many questions remain unanswered. 2,3 It is important to elucidate the molecular mechanisms of CRC tumorigenesis and progression to facilitate the development of effective treatments.…”

Section: Introductionmentioning

confidence: 99%

Small nucleolar RNA host gene 1 promotes development and progression of colorectal cancer through negative regulation of miR‐137

Yin

Peng

et al. 2019

Molecular Carcinogenesis

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Small nucleolar RNA host gene 1 (SNHG1) is critical in the progression of cancers. However, the mechanism by which SNHG1 regulates the progression of colorectal cancer (CRC) remains unclear. Expressions of SNHG1 and miR‐137 in CRC tissues and cell lines were evaluated by quantitative real‐time polymerase chain reaction. A luciferase reporter gene assay was conducted to investigate miR‐137 target. Additionally, RNA pull‐down assay was performed to explore the physical association between miR‐137, SNHG1, and RNA induced silencing complex (RISC). Cell cycling and invasion were examined by flow cytometry (FCM) and transwell assays. The in vivo carcinogenic activity of SNHG1 was examined using murine xenograft models. Expression of RICTOR, serine/threonine kinase 1 (AKT), serum and glucocorticoid‐inducible kinase 1 (SGK1), p70S6K1, and LC3II/LC3I ratio was examined by Western blot analysis. SNHG1 upregulation was observed in CRC tissues and cell lines, which was associated with the lymph node metastasis, advanced TNM stage and poorer prognosis. SNHG1 increased RICTOR level in CRC via sponging miR‐137. In addition, SNHG1 silencing inhibited CRC cell proliferation and migration in vitro and in vivo. SNHG1 regulated RICTOR expression by sponging miR‐137 and promoted tumorgenesis in CRC.

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“…Different resistance of cells to the applied treatment may also determine this phenomenon. The only surviving cells are those capable of adjusting to environmental changes by developing efficient protective mechanisms; it is these cells that contribute to disease recurrence [34,35].…”

Section: The Role Of Stem Cells In Carcinogenesismentioning

confidence: 99%

Cancer stem cells – a new chance for successful treatment of cancer

Badowska-Kozakiewicz¹,

Budzik²

2015

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Cancer stem cells are undifferentiated cells capable of being transformed into all types of cells comprising the tumour mass. As demonstrated by recent findings, they are responsible for the development of both haematopoietic malignancies and solid lesions. Cancer stem cells determine the unlimited growth of tumours and the variety of their morphology; they are also suspected of being the factor responsible for metastases. Their capability for renewal is the cause of disease recurrences even after long remission periods. Studies have shown that cancer stem cells may develop from normal stem cells, mature cells, and differentiated, or already transformed cells. What differentiate these cells from other cancer cells are rare mitotic divisions, which play a protective role for the cancer genome. StreszczenieNowotworowe komórki macierzyste to niezróżnicowane komórki zdolne do przekształcania się we wszystkie typy komórek budujących masę nowotworu. Jak się okazało w ostatnich latach, odpowiedzialne są zarówno za rozwój nowotworów układu krwiotwórczego, jak i powstawanie zmian litych. To właśnie te komórki warunkują nieograniczony wzrost nowotworów, ich różnorodność w budowie morfologicznej oraz -jak się przypuszcza -są czynnikiem powodującym powstawanie przerzutów. Ich zdolność do odnowy jest przyczyną nawrotów choroby, nawet po dłuższych okresach remisji. Wyniki badań wykazały, że nowotworowe komórki macierzyste mogą się rozwijać z prawidłowych komórek macierzystych, komórek dojrzałych, zróżnicowanych oraz komórek już transformowanych nowotworowo. Cechą wyróżniającą nowotworowe komórki macierzyste, w odróżnieniu od pozostałych komórek nowotworowych, są rzadkie podziały mitotyczne, pełniące funkcję ochronną dla genomu komórek nowotworu. Stem cellsNormal stem cells (NSC) are relatively non-specialised cells capable of division leading to identical offspring cells (self-renewal potential), as well as differentiation into one or more types of specialised cells in particular conditions (differentiation potential). This distinguishes these cells from other cells of the human body, which die after reaching their division limit.Stem cell divisions can be classified into two types: symmetric division leading to two stem cells that maintain the traits of the parent cell; and asymmetric division, leading to one stem cell identical to the parent cell and another one that undergoes differentiation or, in particular conditions, apoptosis [1]. Stem cells collected from blastocyst embryos are capable of differentiating into any type of systemic cells; these are referred to as embryonic stem cells. Stem cells are also present in mature organisms; they are known as somatic or adult stem cells. However, they are capable of differentiating only into some types of specialised cells. Although the quantity of NSCs in the human body is very low (they account for less than one per million of all body cells), ongoing studies have allowed us to isolate and multiply these cells with ever increasing efficacy while offering chances for b...

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The role of cancer stem cells in pathogenesis of colorectal cancer

Cited by 14 publications

References 0 publications

A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer

A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer

Small nucleolar RNA host gene 1 promotes development and progression of colorectal cancer through negative regulation of miR‐137

Cancer stem cells – a new chance for successful treatment of cancer

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