1988
DOI: 10.1016/0027-5107(88)90074-7
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The role of blood platelets in nucleoside metabolism: assay, cellular location and significance of thymidine phosphorylase in human blood

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Cited by 24 publications
(11 citation statements)
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“…Blood platelets are one of the richest sources of TP20. Chemotherapy induced thrombocytopenia may reduce the amount of TP and then weak the role of TP.…”
Section: Discussionmentioning
confidence: 99%
“…Blood platelets are one of the richest sources of TP20. Chemotherapy induced thrombocytopenia may reduce the amount of TP and then weak the role of TP.…”
Section: Discussionmentioning
confidence: 99%
“…Although TP is not a secreted protein, high cellular turnover and substantial cell necrosis are thought to occur inside solid tumors, permitting intracellular enzymes to spill into the plasma, thereby raising plasma TP. For these reasons, we assumed that intracellular TP activity was proportional to the amount of D-dRib produced, although we did not directly measure the amount of D-dRib produced in TP-overexpressing cells (21). We observed that the addition of TP or D-dRib promoted invasion of gastric cancer cells and that this activity was more pronounced in TP-overexpressing cells.…”
Section: Discussionmentioning
confidence: 95%
“…AZT is an example of a thymidine analog that is not a substrate for thymidine phos phorylase [17]; however, we have shown that it is only as active as IUDR in reducing for mation of viral plaques in human kératino cytes infected with HSV-1. Drugs which combine the features of AZT, i.e.…”
Section: Discussionmentioning
confidence: 99%
“…The studies with IUDR indicate that human kér atinocytes infected in vitro with HSV-1 are useful model system that possess some im portant biochemical features of the human epidermis. We have extended the use of this model to measure the ID5o values of two new thymidine analogs, BVDU and AZT, that were selected because of their difference as substrates for thymidine phosphorylase; BVDU is a substrate for thymidine phos phorylase [16] whereas AZT is not [17]. The ID50 of BVDU in HSV-1-infected human kératinocytes was 0.18 pM (table 3); addi tion of 3 pA/ thymidine reduced the activity of BVDU by threefold (data not shown).…”
Section: Effect O F 6-at and Thymidine On The An Tiviral Activity O Fmentioning
confidence: 99%