1991
DOI: 10.1159/000210964
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Antiviral Activity of 5-Iodo-2’-Deoxyuridine and Related Drugs in Human Keratinocytes Infected in vitro with Herpes simplex Virus Type 1

Abstract: 5-Iodo-2′-deoxyuridine (IUDR) is a potent topical antiviral agent in experimental animals but is less active in man for treating cutaneous viral infections. We have shown here that IUDR is 5 times less active in human keratinocytes infected in vitro with herpes simplex virus type 1 than in guinea pig embryo cells infected in culture. To account, in part, for this difference in activity of IUDR, we measured the capacity of these different cultures to catabolize and thus inactivate the drug. IUDR is catabolized … Show more

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Cited by 2 publications
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“…The first antiviral drug 5-iodo-2′-deoxyuridine (idoxuridine, IDU) was designed for the herpes virus infection in 1960. 51 Computer aided drug design (CADD) played an important role in designing a suitable antiviral drug against the deadly viral infection. There are two types of CADD, structure based and ligand based.…”
Section: Current Status Of Biocomputational Approaches In Clinical Vi...mentioning
confidence: 99%
“…The first antiviral drug 5-iodo-2′-deoxyuridine (idoxuridine, IDU) was designed for the herpes virus infection in 1960. 51 Computer aided drug design (CADD) played an important role in designing a suitable antiviral drug against the deadly viral infection. There are two types of CADD, structure based and ligand based.…”
Section: Current Status Of Biocomputational Approaches In Clinical Vi...mentioning
confidence: 99%