The Role of Biodegradable Engineered Scaffold in Tissue Engineering

Amoabediny, Ghassem; Salehi, Asiyeh; Heli, Bentolhoda

doi:10.5772/24331

Cited by 16 publications

(10 citation statements)

References 53 publications

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“…Bio‐degradation is one of the most important and vital features of scaffolds to be utilized in biomedical purposes 58‐62 . In the tissue engineering context, the control and engineering of the degradation extent of fabricated scaffolds can be considered as an important issue 13,62,63 . In this regard, both hydrolytic and accelerated degradation analyses were carried out to investigate the effects of GO nanosheets and also GO‐CS nano‐hybrids on the degradation of here‐fabricated scaffolds.…”

Section: Resultsmentioning

confidence: 99%

Tuning polylactic acid scaffolds for tissue engineering purposes by incorporating graphene oxide‐chitosan nano‐hybrids

Majidi

Babaei

Kazemi‐Pasarvi

et al. 2020

Polymers for Advanced Techs

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The main goal of this study was to take an effective approach to promote polylactic acid (PLA) bio‐applications. In this regard, graphene oxide (GO) and spherical structure of GO‐chitosan nano‐hybrids (GO‐CS) were successfully synthesized and characterized using transmission electron microscopy, atomic force microscopy, Fourier‐transform infrared, UV–Vis, and elemental analyses. Thereafter, PLA scaffolds containing 1 wt% and 2 wt% of synthesized nanomaterials were fabricated through the solvent casting/particulate leaching procedure. Then, the biodegradability, cell adhesion, and bio‐safety properties of the prepared scaffolds were investigated. The results of bio‐degradation analyses demonstrated that the used nanomaterials prevented PLA from rapid and excessive degradation. The cell viability and contact angle results revealed that the surface hydrophilicity of PLA scaffolds was noticeably enhanced using both GO and GO‐CS nanoparticles. Although scaffolds containing GO represented a more hydrophilic surface, their cell viability reduced as a consequence of GO cytotoxicity. It was also revealed that incorporation of GO‐CS nano‐hybrids into PLA scaffold tuned the cell viability through facilitating cell adhesion, growth, and proliferation processes.

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Section: Resultsmentioning

confidence: 99%

Tuning polylactic acid scaffolds for tissue engineering purposes by incorporating graphene oxide‐chitosan nano‐hybrids

Majidi

Babaei

Kazemi‐Pasarvi

et al. 2020

Polymers for Advanced Techs

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“…Infection is another major problem that hinders wound healing and can cause various life-threatening complications, such as multiple organ system defects, bacteremia, and sepsis [ 9 ]. The primary approach to overcoming this problem is using wound dressings that contain antibacterial agents on the surface, which can gradually release the agents into the wounded area [ 10 , 11 ]. Effective antibacterial wound dressings have recently attracted a great deal of attention from researchers because they can inhibit the growth of Gram-positive and Gram-negative bacteria in the wound area [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…The range of the fibers’ diameter is from several micrometers down to a few nanometers. Their high surface area and high porosity subsequently resulted in effective controlled delivery of drugs and different biological molecules to the surrounding environment [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Bromelain- and Silver Nanoparticle-Loaded Polycaprolactone/Chitosan Nanofibrous Dressings for Skin Wound Healing

Saghafi,

Baharifar,

Najmoddin

et al. 2023

Gels

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A cutaneous wound is caused by various injuries in the skin, which can be wrapped with an efficient dressing. Electrospinning is a straightforward adjustable technique that quickly and continuously generates nanofibrous wound dressings containing antibacterial and anti-inflammatory agents to promote wound healing. The present study investigated the physicochemical and biological properties of bromelain (BRO)- and silver nanoparticle (Ag NPs)-loaded gel-based electrospun polycaprolactone/chitosan (PCL/CS) nanofibrous dressings for wound-healing applications. Electron microscopy results showed that the obtained nanofibers (NFs) had a uniform and homogeneous morphology without beads with an average diameter of 176 ± 63 nm. The FTIR (Fourier transform infrared) analysis exhibited the loading of the components. Moreover, adding BRO and Ag NPs increased the tensile strength of the NFs up to 4.59 MPa. BRO and Ag NPs did not significantly affect the hydrophilicity and toxicity of the obtained wound dressing; however, the antibacterial activity against E. coli and S. aureus bacteria was significantly improved. The in vivo study showed that the wound dressing containing BRO and Ag NPs improved the wound-healing process within one week compared to other groups. Therefore, gel-based PCL/CS nanofibrous dressings containing BRO and Ag NPs could be a promising solution for healing skin wounds.

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“…Currently, the use of biomaterials is well established in the fields of bioengineering and nanotechnology because these materials have important characteristics that can help improve the physical and chemical properties of existing materials. Moreover, certain processes can be applied to materials to enable them to serve as a structure that complements regenerating tissues without certain disadvantages [9], or in a matrix form with desirable properties that can meet application constraints that would otherwise require material replacement.…”

Section: Introductionmentioning

confidence: 99%

Study of Spider Silk Fibers by Raman Microscopy

Vargas-Charry¹,

Vargas‐Hernández²

2018

AJAC

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Spider silk fibers of species of the genera Araneus, Gasteracantha, and Linothele sericata were studied. The fibers are composed of axial threads and lateral villi, allowing adhesion to surfaces. Raman spectroscopy was used to determine the surface and internal composition of the threads forming the structure. In the three species, the characteristic amino acid peaks of the spider web were found between 2871 and 2975 cm −1 , which belong to L-glycine, L-alanine, L-glutamine, and L-proline. The threads are composed of a protective layer mainly composed of amides, alanine, and glycine. The fibrils surrounding the axial fibers consist mainly of amide II (1533 cm −1), which allows adhesion between the thread and the surfaces onto which the spider weaves the web. For the genus Linothele sericata, there is a peak on the surface of this spider web located at 2145 cm −1 , which is associated with isonitriles with R-N-C bonds.

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The Role of Biodegradable Engineered Scaffold in Tissue Engineering

Cited by 16 publications

References 53 publications

Tuning polylactic acid scaffolds for tissue engineering purposes by incorporating graphene oxide‐chitosan nano‐hybrids

Tuning polylactic acid scaffolds for tissue engineering purposes by incorporating graphene oxide‐chitosan nano‐hybrids

Bromelain- and Silver Nanoparticle-Loaded Polycaprolactone/Chitosan Nanofibrous Dressings for Skin Wound Healing

Study of Spider Silk Fibers by Raman Microscopy

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