The Role of Bioactive Compounds in Natural Products Extracted from Plants in Cancer Treatment and Their Mechanisms Related to Anticancer Effects

Abstract

Cancer is one of the greatest causes of death worldwide. With the development of surgery, radiotherapy, and medical agents, the outcomes of cancer patients have greatly improved. However, the underlying mechanisms of cancer are not yet fully understood. Recently, natural products have been proven to be beneficial for various conditions and have played important roles in the development of novel therapies. A substantial amount of evidence indicates that bioactive compounds could improve the outcomes of cancer patients via various pathways, such as endoplasmic reticulum stress, epigenetic modification, and modulation of oxidative stress. Here, we review the current evidence of bioactive compounds in natural products for the treatment of cancer and summarize the underlying mechanisms in this pathological process.

Unprecedented Approach of Fabrication and Analysis of a Bioactive PDMS/Hydroxyapatite/Graphene Nanocomposite Scaffold with a Vascular Channel to Combat Carcinogenesis

“…Interestingly, the vascular PDMS/HA/Gr-based hybrid nanocomposite showed highest swelling rate constant K swell and lowest degradation rate constant K degrade . It further indicates that the bioactive HA and/or graphene particles may degrade or release from the PDMS matrix and interact with the normal and cancerous cells easily. − Here, the best increased mass indicates the hydrophilic nature of the PDMS/HA/Gr scaffold, but the lowest degradation suggests the interphase molecules, which helped to decelerate the unwanted reactions in the matrix. This could be due to the result of the interfacial or interphase effect of molecular OH of HA on the Si–OH or CH 3 –OH of PDMS matrix.…”

Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling

“…This is not only due to their diverse chemical structures and biological activities, but also because of their lower toxicity compared with drugs synthesized chemically ( 29 ). Therefore, identifying natural plant extracts and their functional mechanisms has become a major area of research ( 30 ). The present study highlighted the anti-tumor effects of icariin-curcumol on PCa cells.…”

Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview

“…[90] Bioactive compounds have emerged as potential inhibitors of angiogenesis, disrupting this vital supply chain and thereby impairing tumor growth and metastasis. [9,91] Harmine and certain β-carboline derivatives have been shown to possess anti-angiogenic properties. [92] They can limit the proliferation of vascular endothelial cells and reduce the production of pro-angiogenic factors, thereby inhibiting the formation of new blood vessels that are crucial for tumor growth and metastasis.…”