Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling
Wen Sheng,
Bonan Li,
Tiansong Sun
et al.
Abstract:Ferroptosis is a form of regulatory cell death that relies on iron and reactive oxygen species (ROS) to inhibit tumors. The present study aimed to investigate whether icariin-curcumol could be a novel ferroptosis inducer in tumor inhibition. Various concentrations of icariin-curcumol were used to stimulate prostate cell lines (RWPE-2, PC-3, VCAP and DU145). Small interfering negative control (si-NC) and si-nuclear factor erythroid 2-related factor 2 (Nrf2) were used to transfect DU145 cells. Cell viability was… Show more
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