The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview

Bobáľ, Pavel; Laštovičková, Markéta; Bobáľová, Janette

doi:10.3390/ijms222413345

Cited by 5 publications

(2 citation statements)

References 96 publications

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“…ATRA is now widely used in preclinical and clinical studies and has shown great anticancer potential in phase II and III clinical trials in patients with various cancers [180]. Specifically, ATRA has been shown to reverse the EMT process in breast cancer cells and hepatocarcinoma cells [195][196][197]. Compared with the prevention of EMT induction, a promising alternative strategy is to selectively target EMT-induced mesenchymal-like cancer cells by therapeutically inhibiting the functions of EMT-specific markers.…”

Section: Other Emt-targeted Therapies In Clinical Applicationsmentioning

confidence: 99%

The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update

Zhu

Lin

et al. 2022

Respir Res

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Cigarette smoke is a complex aerosol containing a large number of compounds with a variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly increases the risk of a variety of diseases, including chronic obstructive pulmonary disease (COPD) and lung cancer. Epithelial–mesenchymal transition (EMT) is a unique biological process, that refers to epithelial cells losing their polarity and transforming into mobile mesenchymal cells, playing a crucial role in organ development, fibrosis, and cancer progression. Numerous recent studies have shown that EMT is an important pathophysiological process involved in airway fibrosis, airway remodeling, and malignant transformation of COPD. In this review, we summarized the effects of cigarette smoke on the development and progression of COPD and focus on the specific changes and underlying mechanisms of EMT in COPD induced by cigarette smoke. We spotlighted the signaling pathways involved in EMT induced by cigarette smoke and summarize the current research and treatment approaches for EMT in COPD, aiming to provide ideas for potential new treatment and research directions.

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Section: Other Emt-targeted Therapies In Clinical Applicationsmentioning

confidence: 99%

The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update

Zhu

Lin

et al. 2022

Respir Res

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“…Subsequently, ATRA has also been used in the treatment of central nervous system disorders (depression), allergic disorders (asthma), metabolic disorders (atherosclerosis), infectious disorders (invasive pulmonary aspergillosis and bacterial infections), tumor immunity and other diseases ( Sakamoto et al, 2015 ; Hu et al, 2020 ; Campione et al, 2021 ; Kalisz et al, 2021 ; Ma et al, 2022 ). In solid tumors, ATRA promotes programmed death ligand-1 (PD-L1) expression to modulate immunosurveillance in gastric cancer (GC), ATRA treats breast cancer by reversing the mesenchymal transcription programs, and disruption of ATRA signaling plays a role in driving aberrant behavior in cancer stem cells ( Bobal et al, 2021 ; Ma et al, 2022 ; Brown, 2023 ). ATRA is not new to hematologists.…”

Section: Introductionmentioning

confidence: 99%

All-trans retinoic acid in hematologic disorders: not just acute promyelocytic leukemia

Chen,

Tong,

et al. 2024

Front. Pharmacol.

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All-trans retinoic acid (ATRA) plays a role in tissue development, neural function, reproduction, vision, cell growth and differentiation, tumor immunity, and apoptosis. ATRA can act by inducing autophagic signaling, angiogenesis, cell differentiation, apoptosis, and immune function. In the blood system ATRA was first used with great success in acute promyelocytic leukemia (APL), where ATRA differentiated leukemia cells into mature granulocytes. ATRA can play a role not only in APL, but may also play a role in other hematologic diseases such as immune thrombocytopenia (ITP), myelodysplastic syndromes (MDS), non-APL acute myeloid leukemia (AML), aplastic anemia (AA), multiple myeloma (MM), etc., especially by regulating mesenchymal stem cells and regulatory T cells for the treatment of ITP. ATRA can also increase the expression of CD38 expressed by tumor cells, thus improving the efficacy of daratumumab and CD38-CART. In this review, we focus on the mechanism of action of ATRA, its role in various hematologic diseases, drug combinations, and ongoing clinical trials.

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Hypophosphorylation of retinoic acid receptor alpha inhibits triple-negative breast cancer cell migration and invasion

Ying

Zheng

et al. 2022

ARCH BIOL SCI BELGRA

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Retinoic acid receptor ? (RAR?) is a transcription factor that plays an essential role in tumor progression. Triple-negative breast cancer (TNBC) is a subtype of breast carcinoma with a poor prognosis due to early therapeutic escape from conventional treatments and aggressive metastatic relapse by the occurrence of an epithelial-mesenchymal transition (EMT). However, as the expression level of RAR? does not correlate with the overall survival of TNBC patients, we speculate that post-translational modification such as phosphorylation of RAR? may be involved in EMT and TNBC metastasis. After overexpressing a phosphorylation-defective mutant of RAR? at serine 77 residue (RAR?S77A), we found that RAR? hypophosphorylation inhibited MDA-MB-231 cell motility and migration in vitro while reducing the lung metastatic potential in vivo. This was accompanied by increased expression of the epithelial marker E-cadherin and decreased expression of the mesenchymal markers ?-catenin and zinc finger E-box-binding homeobox 1 (ZEB1) in agreement with the suppression of EMT. Interestingly, the overexpression of wild-type RAR? in the presence of the RAR? agonist AM580 failed to suppress EMT and cell migration. These results indicate that hypophosphorylated RAR?S77 can directly mimic activated RAR? to inhibit EMT and migration/invasion of cells, thus providing a novel target in the therapeutic intervention of TNBC.

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The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview

Cited by 5 publications

References 96 publications

The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update

The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update

All-trans retinoic acid in hematologic disorders: not just acute promyelocytic leukemia

Hypophosphorylation of retinoic acid receptor alpha inhibits triple-negative breast cancer cell migration and invasion

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