2010
DOI: 10.2174/1573210ccr06210403x
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The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease

Abstract: Endothelium plays a crucial role in the maintenance of vascular tone and structure. Endothelial dysfunction is known to precede overt coronary artery disease. A number of cardiovascular risk factors, as well as metabolic diseases and systemic or local inflammation cause endothelial dysfunction. Nitric oxide (NO) is one of the major endothelium derived vaso-active substances whose role is of prime importance in maintaining endothelial homeostasis. Low levels of NO are associated with impaired endothelial functi… Show more

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Cited by 42 publications
(63 citation statements)
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References 88 publications
(97 reference statements)
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“…In the present study, the mean serum level of the endogenous eNOS inhibitor and L-Arg analog ADMA was similar in ME/CFS patients and healthy controls. ADMA is usually elevated in cardiovascular endothelial dysfunction (50), indicating that the endothelial dysfunction mechanisms in ME/CFS, mainly affecting women of fertile age, differ from those in cardiovascular diseases.…”
Section: Discussionmentioning
confidence: 99%
“…In the present study, the mean serum level of the endogenous eNOS inhibitor and L-Arg analog ADMA was similar in ME/CFS patients and healthy controls. ADMA is usually elevated in cardiovascular endothelial dysfunction (50), indicating that the endothelial dysfunction mechanisms in ME/CFS, mainly affecting women of fertile age, differ from those in cardiovascular diseases.…”
Section: Discussionmentioning
confidence: 99%
“…The relationship between the increase in ADMA levels and endothelial dysfunction has been established clearly. ADMA level has also been found to be influential in diabetes mellitus, chronic renal failure, metabolic syndrome, and Behçet's disease (14)(15)(16).…”
Section: Discussionmentioning
confidence: 99%
“…Ezek tanulsága szerint az elhízott, hypertoniás, diabeteses, hypercholesterinaemiás, illetve dohányzó betegeknél a kontrollcsoporthoz képest magasabb az ADMA koncentrációja. Jellemzően emelkedett az ADMA szintje stroke-on átesett betegekben, végstádiumú veseelégte-lenségben és pangásos szívelégtelenségben szenvedőknél is [19][20][21].…”
Section: Adma éS a Cardiovascularis Rizikóunclassified