The role of antibiotic prophylaxis in mesh repair of primary inguinal hernias using prolene hernia system: a randomized prospective double-blind control trial

Jain, Sudhir; Jayant, Mayank; Norbu, Choden

doi:10.1258/td.2007.060031

Cited by 31 publications

(40 citation statements)

References 18 publications

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“…They concluded that antibiotic prophylaxis has no benefit in the incidence of SSI in elective repair of inguinal hernias with mesh. 18 Similar results were documented by Jain et al, 19 Tzovaras et al, 20 and Aufenacker et al, 21 which did not support the use of prophylactic antibiotics in low-risk patients with inguinal mesh hernioplasty.…”

Section: Discussionsupporting

confidence: 56%

The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh

Bahar

Nooghabi

et al. 2015

Asian Journal of Surgery

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Section: Discussionsupporting

confidence: 56%

The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh

Bahar

Nooghabi

et al. 2015

Asian Journal of Surgery

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“…[8], [19], [20] Recent studies in Indian setting have consistently showed similar incidences of infection in the antibiotics prophylaxis group and control group. [21], [22], [23] However, in one of the studies the incidence of infection in the control group was quiet high.(10.5%). [21] In the recent Cochrane review, which evaluated patients of hernioplasty subgroup, showed that the antibiotic prophylaxis show a significant reduction of wound infection rates.…”

Section: Graphmentioning

confidence: 89%

The Role of Single Dose Antibiotic Prophylaxis in Open Mesh Repair of Inguinal Hernia : A Prospective, Double Blind Randomized Trial

Razack¹,

Kapoor²,

Tambat³

2015

jemds

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OBJECTIVE:To assess the value of single-dose, intravenous, prophylactic antibiotic in the prevention of wound infections during tension free inguinal hernia mesh repair by a double-blind, prospective, randomized trial. BACKGROUND: Hernia repair is considered as one of the so-called 'clean' operations which may not require antibiotic coverage. Many surgeons, however, continue to give antibiotics empirically, as prophylaxis. This practice was more widely used after the establishment of the tension-free mesh repair technique as the method of choice for hernia repair, because of the fear of infection of the introduced foreign body. Several controlled randomised trials have been published on this topic, even before the introduction of the mesh repair techniques, however results are conflicting. METHODS AND MATERIALS: 200 patients were included in the study and the study population was randomized in two groups. The study group was administered parenteral cefazolin while the control group received placebo preoperatively. Follow up was done for 30 days post-surgery which included 180patients.The study was a double-blind randomized controlled trial, the results of which were analyzed statistically. RESULT: The overall infection rate was 8.3% (15 out of 180). The incidence of wound infection in antibiotic group was 7.4% and 9.3% in control group. There was no statistically significant difference in the infection rates between the two groups. CONCLUSION: Antibiotics showed a protective effect in preventing SSI after mesh inguinal hernia repair. However significant values cannot be obtained and cost effectiveness of antibiotic prophylaxis needs further evaluation. Therefore routine use is not recommended.

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“…The number needed to treat was calculated from the ORs and the background risk of incision infection in patients in the control Table 1. Study characteristics and quality evaluation of each selected study on the use of antibiotic prophylaxis to prevent postoperative complications in patients undergoing tension-free hernioplasty Characteristic Perez et al 18 Yerdel et al 19 Aufenacker et al 20 Celdran et al 21 Tzovaras et al 22 Jain et al 23 Jadad RESEARCH group. We also performed a sensitivity analysis adjusted by study quality.…”

Section: Discussionmentioning

confidence: 99%

“…[18][19][20][21][22][23] The characteristics and quality of each selected study are shown in Table 1. The studies were homogeneous in terms of clinical and methodologic criter ia.…”

Section: Primary Outcomementioning

confidence: 99%

“…For incision hematoma, data were extracted from 3 RCTs. 18,19,23 These trials included a total of 749 patients, 18 of whom had an incision hematoma. Among these patients, 11 were in the antibiotic prophylaxis group and 7 patients were in the control group, indicating that antibiotic prophylaxis did not reduce the incidence of incision hematoma compared with the control condition (OR 1.57, 95% CI 0.60-4.10, p = 0.35; Fig.…”

Section: Secondary Outcomementioning

confidence: 99%

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Meta-analysis of the effectiveness of prophylactic antibiotics in the prevention of postoperative complications after tension-free hernioplasty

Lai

Zhang

et al. 2012

Can J Surg

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Background: Previous reviews of the effectiveness of antibiotic prophylaxis for elective inguinal hernia repair were not conclusive owing to the limited number of patients enrolled in randomized controlled trials (RCTs). However, since new RCTs involving patients undergoing tension-free hernioplasty have been published in recent years, we performed a new meta-analysis to evaluate the effectiveness of antibiotic prophylaxis in the prevention of postoperative complications after this procedure. Methods:We performed a meta-analysis of RCTs studying the use of antibiotic prophylaxis to prevent postoperative complications in patients undergoing tension-free hernioplasty. Results Conclusion:Antibiotic prophylaxis use in patients undergoing tension-free hernioplasty decreases the rate of incision infection by 55%.Contexte : Les études antérieures sur l'efficacité de la prophylaxie aux antibiotiques pour la réparation élective d'une hernie inguinale n'étaient pas concluantes à cause du nombre limité de patients inscrits aux essais contrôlés randomisés (ECR). Cependant, comme les résultats de nouveaux ECR mettant en cause des personnes qui ont subi une hernioplastie sans tension ont été publiés au cours des dernières années, nous avons procédé à une nouvelle méta-analyse pour évaluer l'efficacité de la prophylaxie aux antibiotiques dans la prévention des complications postopératoires. Méthodes :Nous avons effectué une méta-analyse d'ECR portant sur l'utilisation de la prophylaxie aux antibiotiques pour prévenir les complications postopératoires chez tous les patients qui ont subi une hernioplastie sans tension.

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The role of antibiotic prophylaxis in mesh repair of primary inguinal hernias using prolene hernia system: a randomized prospective double-blind control trial

Cited by 31 publications

References 18 publications

The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh

The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh

The Role of Single Dose Antibiotic Prophylaxis in Open Mesh Repair of Inguinal Hernia : A Prospective, Double Blind Randomized Trial

Meta-analysis of the effectiveness of prophylactic antibiotics in the prevention of postoperative complications after tension-free hernioplasty

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