The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh

Bahar, Mostafa Mehrabi; Nooghabi, Azadeh Jabbari; Nooghabi, Mehdi Jabbari; Jangjoo, Ali

doi:10.1016/j.asjsur.2015.01.006

Cited by 16 publications

(11 citation statements)

References 16 publications

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“…Of these, 195 unique articles were selected by title or abstract data; 98/195 of these did not meet the inclusion criteria. This left a total of 99 articles for evaluation: 34 from Asia (Austin et al, 2004;Duerink et al, 2006;Kanafani et al, 2006;Wu et al, 2006;Ali et al, 2009;Buang and Haspani, 2012;Ee et al, 2014;El Beltagy et al, 2010;Khan et al, 2010Khan et al, , 2011Lee et al, 2007Lee et al, , 2010Lee et al, , 2015Malik et al, 2009;Mathur et al, 2013;Memon et al, 2013;Nausheen et al, 2013;Sangrasi et al, 2008;Saramma et al, 2011;Akhter et al, 2016;Al-Mulhim et al, 2014;Bibi et al, 2015;Hey et al, 2017;Jyothirmayi et al, 2017;Mehrabi Bahar et al, 2015;Mundhada and Tenpe, 2015;Ng et al, 2015;Pardhan et al, 2013;Sahu et al, 2016;Shah et al, 2015Shah et al, , 2017Singh et al, 2015;Vaze et al, 2014;Yu et al, 2015), 27 from LATAM (Alvarez-Moreno et al, 2014;Bannura et al, 2016;Barbosa et al, 2004;Bellusse et al, 2015;da Cunha et al, 2011;…”

Section: Resultsmentioning

confidence: 99%

“…,Gao et al (2010),Gil-Londoño et al (2016),Giri et al (2008),Hafez et al (2012),Hao et al (2013),Hernaiz-Leonardo et al (2017),Hey et al (2017),Ibrahim et al (2014),Jyothirmayi et al (2017),Kanafani et al (2006),Khan et al (2010),Khan et al (2011),Ledur et al (2011),Lee et al (2007),Lee et al (2010),Lee et al (2015),Legesse Laloto et al (2017),Leon et al (2011),Li et al (2013),Liu et al (2017),Lyimo et al (2013),Madu et al (2011), El Maerrawi and Carvalho (2015),Malik et al (2009),Martins et al (2008),Marwa et al (2015),Mathur et al (2013),Mawalla et al (2011),Mehrabi Bahar et al (2015),Memon et al (2013),Mundhada and Tenpe (2015),Nagaya et al (2017),Ng et al (2015),Ning et al (2014),Nwankwo and Edino (2014),Oliveira and Carvalho (2004),Pardhan et al (2013), Porras-Hernandez et al (2008,Portillo-Gallo et al (2014),Qi et al (2013),Qin et al (2014),Qiu et al (2011),Rabiu ...…”

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confidence: 99%

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Surgical site infection in elective clean and clean-contaminated surgeries in developing countries

Curcio

Cané

Fernández³

et al. 2019

International Journal of Infectious Diseases

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Background: Surgical site infection (SSI) is both the most frequently studied healthcare-associated infection and the most common healthcare-associated infection in the developing world. A systematic review and meta-analysis was conducted to evaluate the relative size of this burden and to estimate the prevalence of SSI in clean and clean-contaminated surgeries in a large sample of countries in the developing world. Methods: A systematic search of the MEDLINE/PubMed, Scopus, and LILACS databases was conducted to identify studies providing the prevalence of SSI in elective clean and clean-contaminated surgeries in 39 countries or regions around the world. Data of interest were limited to publications from January 2000 to December 2017. Studies with information on the number of cases of SSI and number of total elective clean and clean-contaminated surgeries during the same period were included in this evaluation. Studies lacking clear definition of the total number of exposed patients were excluded. Results: Based on the combined data from the 99 articles evaluated in this analysis, the overall prevalence of SSI in elective clean and clean-contaminated surgeries was estimated to be 6% (95% confidence interval (CI) 5-7%). This increased to 15% (95% CI 6-27%) when considering only those reports with post-discharge surveillance data. The overall prevalence of SSI in Africa/Middle East, Latin America, Asia, and China was 10% (95% CI 6-15%), 7% (95% CI 5-10%), 4% (95% CI 4-5%), and 4% (95% CI 2-6%), respectively. Significant variability in the data was confirmed by both the funnel plot and the Egger test (p = 0.008). Conclusions: Although the data are variable, it is clear that the incidence of SSI in the developing world is higher than that in the developed world.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Surgical site infection in elective clean and clean-contaminated surgeries in developing countries

Curcio

Cané

Fernández³

et al. 2019

International Journal of Infectious Diseases

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“…Moreover, in a prospective randomized control study evaluating wound infection rates in 395 patients with various types of hernia undergoing elective mesh repair, 237 patients (60.0%) received prophylactic cefazolin (study group), while the remaining 158 patients (40.0%) did not receive any prophylactic antibiotics (control group) [ 29 ]. Patients were monitored for infections at multiple intervals postoperatively, including at 10 days, 30 days, 12 months, and annually for at least two years.…”

Section: Reviewmentioning

confidence: 99%

“…Patients were monitored for infections at multiple intervals postoperatively, including at 10 days, 30 days, 12 months, and annually for at least two years. The results revealed that eight patients (2.03%) experienced infection at the surgical site, with two (1.27%) occurring in the control group and six (2.53%) in the study group, suggesting that preoperative administration of single-dose cefazolin for prosthetic hernia repairs did not markedly decrease the risk of wound infection [ 29 ]. Similarly, in a prospective, randomized, double-blind trial involving 450 patients undergoing primary inguinal hernia repair electively using polypropylene mesh, analysis of 334 out of the 450 patients who completed a one-month follow-up period revealed that the overall infection rate was 8.7% (29 out of 334), with a wound infection incidence of 7% in the antibiotic group and 10.5% in the control group.…”

Section: Reviewmentioning

confidence: 99%

A Comparative Analysis of Prophylactic Antibiotic Administration in Emergency Surgery Versus Elective Surgery: A Comprehensive Review

Meretsky,

Krumbach,

Schiuma

2024

Cureus

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Surgical site infections (SSIs) contribute to increased patient morbidity, prolonged hospital stays, and substantial healthcare costs. Prophylactic antibiotics play a pivotal role in mitigating the risk of SSIs, with their administration being a standard practice before both emergency and elective surgeries. This paper provides a comprehensive review and comparative analysis of the benefits of prophylactic antibiotic administration in emergency surgery versus elective surgery. Through a systematic literature review and analysis of relevant studies identified through PubMed searches, this paper highlights the specific benefits of prophylactic antibiotics between emergency and elective surgeries. The findings underscore the importance of tailored antibiotic regimens and administration protocols to optimize patient care and promote successful surgical outcomes in diverse clinical settings. Further research is warranted to refine guidelines and enhance understanding of the relationship between prophylactic antibiotics and surgical outcomes across different surgical contexts.

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“…The microbiological cultured in these two cases showed infection by Staphylococcus aureus and by Pseudomonas aeruginosaalso in the second case. S. aureus [198] and Staphylococcus epidermidis [199] are the most common microorganisms related to mesh infection (approximately 90%), S. aureus (MRSA) [200], involved in up to 63% of surgical site mesh-related infections [201][202][203], being methicillin-resistant. Other microorganisms related to mesh infection include Streptococcus pyogenes [204], Enterococcus faecalis [205,206], Pseudomonas sp.…”

Section: Chronic Mesh Infection Problemmentioning

confidence: 99%

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

Serrano‐Aroca¹,

Pous‐Serrano²

2021

Preprint

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Worldwide, hernia repair represents one of the most frequent surgical procedures encompassing a global market valued at several billion dollars. This type of surgery usually requires the implantation of a mesh that needs the appropriate chemical, physical and biological properties for the type of repair. This review thus presents a description of the types of hernias, current hernia repair methods, and the state of the art of prosthetic meshes for hernia repair providing the most important meshes used in clinical practice by surgeons working in this area classified according to their biological or chemical nature, morphology and whether bioabsorbable or not. We emphasise the importance of surgical site infection in herniatology, how to deal with this microbial problem, and we go further into the future research lines on the production of advanced antimicrobial meshes to improve hernia repair and prevent microbial infections, including multidrug-resistant strains. A great deal of progress has been made in this biomedical field in the last decade. However, we are still far from an ideal antimicrobial mesh that can also provide excellent integration to the abdominal wall, mechanical performance, low visceral adhesion and minimal inflammatory or foreign body reactions, among many other problems.

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The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh

Abstract: Preoperative administration of single-dose cefazolin for prosthetic hernia repairs did not markedly decrease the risk of wound infection. Our results do not support the use of cefazolin as a prophylactic antibiotic for various kinds of abdominal wall hernia repair with mesh.

Cited by 16 publications

References 16 publications

Surgical site infection in elective clean and clean-contaminated surgeries in developing countries

Surgical site infection in elective clean and clean-contaminated surgeries in developing countries

A Comparative Analysis of Prophylactic Antibiotic Administration in Emergency Surgery Versus Elective Surgery: A Comprehensive Review

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

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