The Role of anti-HBc IgM in Screening of Blood Donors

Kumar, Harsh; Gupta, PK; Jaiprakash, M

doi:10.1016/s0377-1237(07)80013-x

Cited by 25 publications

(35 citation statements)

References 13 publications

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“…anti-HBc) may be considered. 9 Validation of screened nonreactive blood units may be part of the routine process in referrals as part of the quality assurance in the national blood program.…”

Section: Recommendationsmentioning

confidence: 99%

Validation using Nucleic Acid Testing (NAT) on Blood Donor Samples Non-Reactive to Transfusion-Transmissible Viruses by Immunoassay (EIA/ChLIA)

Chamen

Punzalan

et al. 2016

PJP

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Transfusion-transmissible infections (HIV, HBV and HCV) remain a threat to public health specifically in assuring safe transfusion practices. This study aims to determine the ability of a blood service facility to accurately detect HIV, Hepatitis B and C and assess the need to include nucleic acid testing as part of the routine screening algorithm. Of the 3,233 samples from participants with screened sero-negative blood units, testing for HIV and Hepatitis C showed no discrepancies with EIA and NAT in all samples. Testing for Hepatitis B showed 12 (4.00%) samples which are reactive in both EIA and NAT, 3 (0.09%) samples were reactive with EIA only and 48 (1.48%) were detected for the presence of Hepatitis B Virus via NAT.

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Section: Recommendationsmentioning

confidence: 99%

Validation using Nucleic Acid Testing (NAT) on Blood Donor Samples Non-Reactive to Transfusion-Transmissible Viruses by Immunoassay (EIA/ChLIA)

Chamen

Punzalan

et al. 2016

PJP

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“…The IgM class of anti-HBc is the first to appear and indicates a recent infection, while IgG anti-HBc appears later during the infection and points to a past HBV infection. 4 The use of HBsAg and anti-HBc screening tests has been the basis of HBV screening in many countries, and this has significantly reduced but not eliminated TAHBV.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of antibody to hepatitis B core antigen among hepatitis B surface antigen-negative blood donors in Ilorin, Nigeria: A cross-sectional study

Ogunfemi¹,

Olawumi²,

Olokoba³

et al. 2017

Mal. Med. J

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BackgroundPost-transfusion hepatitis occurs even with stringent donor selection criteria and screening for hepatitis B surface antigen (HBsAg). The objective of this study was to determine the prevalence of antibody to hepatitis B core antigen (anti-HBc) in HBsAg-negative blood donors. MethodsThis was a cross-sectional study in which 200 HBsAg-negative blood donors were recruited. Screening for viral markers was done using both a rapid test kit and enzyme-linked immunosorbent assay (ELISA) for anti-HBc IgM. Quantitative and qualitative analysis of anti-HBc IgM was done by "capture" enzyme immunoassay using DIA.PRO HBc IgM test kits. The other viral markers were investigated using one step cassette style HBV tests. SPSS version 16 was used for data analysis. A P-value of 0.05 or less was considered significant. ResultsThere were 190 male (95%) and 10 female (5%) blood donors, with a mean age of 31.7 ± 7.9 years. The prevalence of anti-HBc IgM was 4%. The other viral markers (HBeAg, anti-HBeAg, anti-HBs and total anti-HBc) had a prevalence of 1.5%, 23%, 2.5%, and 32.5%, respectively.

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“…In an article in this issue of the journal, Kumar H et al [11], have proposed testing for IgM-anti-HBc amongst voluntary blood donors as a screening procedure for window period hepatitis B in donated blood. IgM-antiHBc may be the only HBV marker present in acute HBV during the "window period" between the disappearance of HBsAg and the appearance of antiHBs.…”

Section: H Epatitis B Virus (Hbv) Infection Is a Health Problemmentioning

confidence: 99%