The role of androgens in determining acne severity in adult women

Cibula, David; Hill, Martin; Vohradníková, O; Kužel, D; Fanta, M.; Živný, J

doi:10.1046/j.1365-2133.2000.03669.x

Cited by 95 publications

(84 citation statements)

References 21 publications

(24 reference statements)

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“…8 Cibula et al demonstrated that, the severity of acne manifestation in adult women was not determined by androgen production and there must therefore be key factors other than androgen levels in the pathogenesis of acne. 6 In our study we found elevated serum testosterone in 7 (10%) cases and below normal level of serum testosterone was found among 13 (18.6%) of the control individuals. The difference between case and control was statistically significant (p<0.001).…”

Section: Discussionmentioning

confidence: 65%

“…Their study suggests that the severity of acne manifestation in adult women is not determined by androgen production. 6 Held et al investigated the relationship between hyperandogenism and acne. Elevated serum androgen levels have been reported in patients with acne resistant to conventional dermatologic therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Androgens enhance the sebum production and follicular keratosis that plays the key role in the aetiology of acne. 6 Acne is a common feature in the course of endocrine diseases, characterized by raised levels of androgens. 3 The mechanisms suggested include: Increased circulating levels of androgens, increased local metabolism of androgens in skin and increased tissue sensitivity to androgens.…”

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confidence: 99%

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Association of Serum Testosterone with Acne Vulgaris in Women

Rahman¹,

Sikder

Rashid

et al. 2012

Bangabandhu Sheikh Mujib Medical University Journal

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Background: Androgens enhance the sebum production and follicular keratosis that plays the key role in the aetiology of acne. Objective: To find out the association between serum testosterone and acne vulgaris. Methods: A case control study was carried out for a period of two years in the outpatient department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Female patients having acne vulgaris were selected as case. Healthy control (age and sex matched) were enrolled from the community. Results: The study showed that the mean age of the cases was 22.43 with standard deviation 5.2 years and the mean age of the control was 23.23 with standard deviation 5.9 years. The mean duration of disease was 62.6 months ranging from 12 months to 300 months. All the patients had presented with comedones (blackheads and whiteheads) followed by 94.3% had papules and 58.6% had pustules. Considering the site of lesion, all the patients had acne in the face. Data analysis revealed that the percentage of serum testosterone above normal was found to be high among the cases with acne (10%) whereas below normal level of serum testosterone was found among the control and the difference was statistically significant (p<0.001). Conclusion:The study found a significant association between serum testosterone and acne vulgaris. As serum testosterone is associated with acne vulgaris, testosterone levels should be measured in patients presenting with acne vulgaris especially in treatment resistant cases and anti-androgen treatment may be indicated in cases with elevated testosterone level.DOI: http://dx.doi.org/10.3329/bsmmuj.v5i1.10980 BSMMU J 2012; 5(1):1-5

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Association of Serum Testosterone with Acne Vulgaris in Women

Rahman¹,

Sikder

Rashid

et al. 2012

Bangabandhu Sheikh Mujib Medical University Journal

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“…10 Uso de cosméticos, alterações hormonais e nutricionais, coexistência de hirsutismo, dermatite seborreica, alopecia, irregularidade menstrual ou aspectos psicoevolutivos são elementos aventados na explicação dos diferentes padrões clínicos e de histó-ria natural da acne em diferentes grupos populacionais. 8,[11][12][13][14][15][16][17][18][19][20] Há carência de pesquisas epidemiológicas que comparem aspectos clínicos associados à acne feminina juvenil e adulta. O presente estudo objetiva analisar as características clínicas e epidemiológicas associadas às diferentes faixas etárias acometidas por acne nessa população.…”

Section: Introductionunclassified

Padrões clínicos de acne em mulheres de diferentes faixas etárias

Schmitt

Masuda

Miot

2009

An. Bras. Dermatol.

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Resumo: FUNDAMENTOS: Acne é dermatose comum que acomete ambos os gêneros e todas as faixas etárias. Mulheres apresentam diferentes padrões clínicos da doença, além de frequente persistência da acne após a adolescência. OBJETIVO: Analisar características clínicas e epidemiológicas associadas às diferentes faixas etárias acometidas por acne feminina. MÉTODOS: Estudo transversal envolvendo mulheres com diagnóstico de acne, atendidas em ambulatório de dermatologia geral. Variáveis relacionadas à doença e às pacientes foram avaliadas com o emprego de questionário padronizado. RESULTADOS: Avaliaram-se 103 pacientes, cuja idade média na época da consulta foi 21,7 ± 7,3 anos. Definiram-se dois subgrupos com idade de corte de 21 anos e idades médias de 15,8 ± 2,3 e 28,0 ± 5,1 anos. Houve correlação entre a duração do quadro e a idade das pacientes na consulta (R = 0,7). Observaram-se diferenças entre os grupos nas frequências de uso de contraceptivo oral combinado (OR = 48,1), lesões no colo (OR = 11,6), lesões no dorso (OR = 0,2), predominância na topografia superior da face (OR = 0,1) e idade de início das lesões (OR = 1,8). No grupo de mulheres adultas, 80% relataram iní-cio do quadro antes dos 20 anos. CONCLUSÕES: Identificaram-se padrões clínicos cronológicos e topográficos que caracterizaram a acne feminina em diferentes faixas etárias, alertando para a importância da abordagem diagnóstica e terapêutica individualizada. Palavras-chave: Acne vulgar; Dermatologia; Estudos transversais; Hiperandrogenismo Abstract: BACKGROUND: Acne is a frequent skin disease that occurs in both sexes and all age-groups. Women present several clinical disease patterns; moreover, persistence after adolescence is common. OBJECTIVE: To analyze clinical and epidemiological characteristics associated with different age-groups affected by acne in women. METHODS: Cross-sectional study involving female patients diagnosed with acne, at a general dermatology outpatient clinic. Variables related to disease and patients were assessed through a standardized questionnaire. RESULTS: One hundred and three women were assessed. The average age of patients at the time of the consultation was 21.7 ± 7.3 years. Two groups were defined (cut-off age of 21 years), with means of 15.8 ± 2.3 and 28.0 ± 5.1 years. There was correlation between disease duration and current age (R=0.7). There were group differences among frequencies of covariables: combined oral contraceptive (OR=48.1), lesions located on upper chest (OR=11.6), lesions on upper dorsum (OR=0.2), predominance on upper half of face (OR=0.1) and age at disease onset (OR=1.8). Among adult women, 80% reported acne onset before 20 years of age. CONCLUSION: Chronologic and topographic patterns of female acne in different age-groups were defined, reinforcing the importance of an individualized diagnostic and therapeutic approach.

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“…30 It is not necessary to demonstrate androgen excess to achieve a benefit from antiandrogen therapy. Clinical observation suggests that deep-seated nodules on the lower face and neck are especially responsive to hormonal therapy.…”

Section: Hormonal Therapiesmentioning

confidence: 99%