Management of acne

Kraft, John; Freiman, Anatoli

doi:10.1503/cmaj.090374

Cited by 113 publications

(99 citation statements)

References 43 publications

(60 reference statements)

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“…Topical retinoids, by acting on follicular keratinocytes, prevent the excessive cornification and follicular blockage, and also decrease the release of inflammatory cytokines. 10 Benzoyl peroxide and antibiotics are the topical antimicrobials which have efficacy in treating inflammatory acne. 10 One of the novel retinoid is adapalene which has efficacy in the topical treatment of acne vulgaris as shown in some studies.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of efficacy and safety of adapalene and benzoyl peroxide-clindamycin combination in the topical treatment of acne vulgaris

Dubey

Amane

2016

Int J Basic Clin Pharmacol

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Section: Discussionmentioning

confidence: 99%

“…10 Benzoyl peroxide and antibiotics are the topical antimicrobials which have efficacy in treating inflammatory acne. 10 One of the novel retinoid is adapalene which has efficacy in the topical treatment of acne vulgaris as shown in some studies. 6,11,12 It is a derivative of naphthoic acid and has retinoid receptor agonistic activity.…”

Section: Discussionmentioning

confidence: 99%

Comparison of efficacy and safety of adapalene and benzoyl peroxide-clindamycin combination in the topical treatment of acne vulgaris

Dubey

Amane

2016

Int J Basic Clin Pharmacol

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“…7 Benzoyl peroxide and antibiotics are the topical antimicrobials which have efficacy in treating inflammatory acne. 8 Topical niacinamide has marked anti-inflammatory properties. 4% Nicotinamide gel for the topical treatment of mild to moderate acne vulgaris.…”

Section: Discussionmentioning

confidence: 99%

A prospective randomised open labelled comparative study of anti inflammatory effects of topical 5% benzoyl peroxide gel vs topical 4% nicotinamide gel for grade I-II acne in a tertiary care hospital

Kumar¹,

Mohan²,

Shwetha³

et al. 2018

Int J Basic Clin Pharmacol

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Background: Acne vulgaris is a dermatological disorder characterised by formation of comedones and inflammatory lesions. The treatment of acne basically involves reduction of lesions. Benzoyl peroxide, in concentrations of 5%, 10%, and 20%, has been used effectively in the treatment of acne for more than 20 years. Nicotinamide/ Niacinamide is a newly-approved anti-acne drug with a potent anti-inflammatory effect. The present study assessed the efficacy of 5% Benzoyl peroxide gel in comparison to 4% Nicotinamide gel for topical treatment of mild to moderate acne vulgaris.Methods: In this study, the patients with mild to moderate acne vulgaris with inflammation were divided into two groups, group I was treated with topical 5% Benzoyl peroxide gel whereas topical Nicotinamide gel was given to the group II. Assessment of efficacy was done by total lesion counting according acne global severity index, the results were compared at the end of 2 weeks and 4 weeks with the baseline values.Results: At the end of this study, it was found that the reduction of inflammatory and total percentage of decrease in counts of lesions from baseline were highly significant in both the groups (p<0.001), between the groups, differences were statistically significant (p<0.001), therefore 5% Benzoyl peroxide gel has better efficacy than 4% Nicotinamide gel.Conclusions: Benzoyl peroxide is more efficacious than 4 % Nicotinamide gel in mild to moderate acne.

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“…It may cure the mother of syphilis but not the infant. If the mother is an HIV carrier, the physician should be aware of [18]. Because it is a category B drug, erythromycin is considered safe during pregnancy, although some studies found an association between use of erythromycin early in pregnancy and cardiovascular malformations, and between prolonged use of erythromycin ethylsuccinate formulation and hepatotoxicity [12•].…”

Section: Macrolidesmentioning

confidence: 99%

“…Several studies have suggested that these retinoids are teratogenic during the first trimester. Both are category C and should not be used during pregnancy [18].…”

Section: Retinoidsmentioning

confidence: 99%

Safety of Common Medications for Treating Dermatology Disorders in Pregnant Women

Malka

Ziv

2013

Curr Derm Rep

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Treating the pregnant woman poses challenges to the physician that requires balancing between eliminating or alleviating a condition or disease and ensuring no untoward effects on the mother and fetus. Despite the importance of the task, human studies are limited for obvious reasons, and animal studies do not fully resemble human physiology. Nevertheless, thanks to epidemiology studies and large-scale reviews of case reports on pregnant patients with comorbidities or refractory diseases that necessitate treatment with drugs of uncertain safety, data are accumulating on the safety of medications during pregnancy. This review summarizes the current literature on the safety during pregnancy of medications frequently used for common dermatologic diseases. The goal is to provide physicians with a handy database for when to, and when not to, prescribe those medications.

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Management of acne

Abstract: Key points• Effective therapies for acne target one or more pathways in the pathogenesis of acne, and combination therapy gives better results than monotherapy.• Topical therapies are the standard of care for mild to moderate acne.

Cited by 113 publications

References 43 publications

Comparison of efficacy and safety of adapalene and benzoyl peroxide-clindamycin combination in the topical treatment of acne vulgaris

Comparison of efficacy and safety of adapalene and benzoyl peroxide-clindamycin combination in the topical treatment of acne vulgaris

A prospective randomised open labelled comparative study of anti inflammatory effects of topical 5% benzoyl peroxide gel vs topical 4% nicotinamide gel for grade I-II acne in a tertiary care hospital

Safety of Common Medications for Treating Dermatology Disorders in Pregnant Women

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