The Role of &amp;beta;-Glucan Receptors on Blood and Tissue Leukocytes in Phagocytosis and Metabolic Activation

Czop, J K

doi:10.1159/000157022

Cited by 80 publications

(42 citation statements)

References 31 publications

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“…Once in the bloodstream or lymph, different receptors on a range of leucocytes are able to bind the glucan molecules (Czop 1986, Chettri et al 2010. Dectin-1 is a transmembrane lectin-like receptor that has been identified on the surface of macrophages, dendritic cells, neutrophils, and certain T-cells in various mammals (Ariizumi et al 2000, Taylor et al 2002, Brown 2006 but not in fish.…”

Section: Discussionmentioning

confidence: 99%

“…(Brown et al 2003, Gantner et al 2003, Brown 2006. Furthermore, the binding may also induce phagocytosis and a subsequent respiratory burst (Czop 1986, Herre et al 2004. A dectin-1 homologue has not yet been found in fish but a complement receptor in carp is known to bind β-glucans (Nakao et al 2003) which could explain glucan effects in fish.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Short- and Long-Term Glucan Feeding of Rainbow Trout (Salmonidae) on the Susceptibility to <I>Ichthyophthirius Multifiliis</I> Infections

Lauridsen¹,

Buchmann

2010

Acta Icth et Piscat

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Lauridsen J.H., Buchmann K. 2010. Effects of short-and long-term glucan feeding of rainbow trout (Salmonidae) on the susceptibility to Ichthyophthirius multifiliis infections. Acta Ichthyol. Piscat. 40 (1): 61-66.Background. Various compounds are being used as immuno-stimulants in various aquaculture feed types but the importance of their prolonged use is at present unknown. It is also true for those intended to modify trout susceptibility to white spot disease caused by Ichthyophthirius multifiliis. The immuno-modulating effects on rainbow trout of short-and long-term feeding using dry feed with inclusion of beta-glucan (0.2%) have therefore been evaluated. Materials and Methods. The immune reactivity was assessed by measuring susceptibility to I. multifiliis infections and plasma lysozyme in the host, factors which are considered innate response parameters. Rainbow trout, Oncorhynchus mykiss (Walbaum, 1792) (Actinopterygii: Salmoniformes: Salmonidae), were fed (control feed or glucan-containing feed) for 14 or 35 days before challenge (exposure to infective I. multifiliis theronts) and the resulting infection (number of trophonts in the skin) was recorded on day 11 post-exposure to theronts. Results. All fish obtained infection following parasite exposure but glucan-fed fish showed a lower infection at day 46 compared to fish fed control-feed. The lysozyme activity of fish plasma was evaluated throughout the experimental period and found slightly but significantly increased in association with glucan-feeding at day 14, 17, and 46. Conclusion.No evidence for an exhaustion of these selected innate response parameters due to prolonged glucan-feeding could be detected within the experimental period of 46 days.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Short- and Long-Term Glucan Feeding of Rainbow Trout (Salmonidae) on the Susceptibility to <I>Ichthyophthirius Multifiliis</I> Infections

Lauridsen¹,

Buchmann

2010

Acta Icth et Piscat

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“…17 Now, we know that CR3 on neutrophils and natural killer cells plays very important roles in ß-glucan-mediated immune responses. [18][19] Additionally, other cell surface molecules such as dectin-1, lactosylceramide (CDw17), some scavenger receptors, and Toll-like receptor 2/6 (TLR2/6) are among those for ß-glucans.…”

Section: Discussionmentioning

confidence: 99%

Differential Adjuvant Effects of Soluble Beta Glucans from Barley and Saccharomyches Cerevisia in Primary and Secondary Humoral Immune Responses

Uslu¹

2011

UHOD

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The purpose of this study was to investigate and compare adjuvant effects of soluble ß-glucans from barley and Saccharomyches cerevisia in induction of antigen specific humoral immune responses. Mice were immunized with conalbumin at a relatively low concentration in the presence of beta glucans. Anti-conalbumin antibodies in the sera of immunized and control mice were quantified by ELISA. At high doses, both of glucans increased effectively levels of circulating IgM and IgG antibodies which were specific for conalbumin. However, coadministration of glucan from barley at 1 µg dose resulted in lower yield in IgG1, IgG2a, IgG2b, and IgA levels in comparison to that of yeast-derived glucan at the same dose. We also found that antigen (conalbumin) specific antibody levels enhanced by ß-glucan from Saccharomyches cerevisia were always higher than those of the glucan from barley. Based on these findings, we concluded that ( ÖZET Saccharomyches cerevisia ve Arpadan Elde Edilen Beta Glukanlar›n Primer ve Sekonder Hümoral ‹mmün Cevaptaki Farkl› Adjuvan EtkisiBu çal›flman›n amac› antijene özgül hümoral immün cevab›n oluflmas› s›ras›nda arpa ve Saccharomyches cerevisia'dan elde edilen çözünebilir ß-glukanlar›n adjuvan etkilerinin araflt›r›lmas›d›r. Fareler beta glukan varl›¤›nda göreceli olarak düflük dozlarda konalbümin ile immünize edildi. ‹mmünize edilmifl ve edilmemifl kontrol fare serumunda anti-konalbumin antikorlar› ELISA yöntemi ile tayin edildi. Yüksek dozlarda uyguland›¤› zaman her iki glukan konalbümine özgül IgM ve IgG antikor seviyelerini etkin bir flekilde artt›rd›. Ancak, ayn› dozda maya (Saccharomyches cerevisia) kökenli glukan ile karfl›laflt›r›ld›¤›nda, konalbümin ve 1 µg arpadan elde edilen glukan›n birlikte enjeksiyonu, daha düflük seviyelerde IgG1, IgG2a, IgG2b, and IgA üretimine neden oldu. Saccharomyches cerevisia köken-li glukan taraf›ndan artt›r›lan antijene özgül antikor seviyeleri, arpa kökenli glukan taraf›ndan artt›r›lan antijene özgül antikor seviyelerinden daima daha fazla oldu. Bu sonuçlar temel al›narak antijene özgül hümoral immün yan›t oluflmas›nda, mayadan elde edilen (1,3),( 1,6)-ß-D-glukan›n, arpadan elde edilen (1,3),( 1,4)-b-D-glukan'a göre daha fazla immünostimülan aktiviteye sahip oldu¤u düflünüle-bilir.

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“…The putative β-glucan receptor was first identified as a receptor capable of ingesting zymosan [61]. Since this inaugural study, several membrane receptors were presented as serious candidates to be the β-glucan receptor, among which lactosylceramide receptor [62], scavenger receptors, CR3 and dectin-1.…”

Section: β-Glucan Receptormentioning

confidence: 99%

Phagocytic functions of microglial cells in the central nervous system and their importance in two neurodegenerative diseases: multiple sclerosis and Alzheimer’s disease

Choucair¹,

Laporte

Lévy³

et al. 2006

Open Life Sciences

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Microglial cells are the resident phagocytic cells of the central nervous system (CNS). They possess a wide range of receptors allowing them to identify and internalize numerous pathogens. We will discuss here the role of the most important receptors of microglia involved in non-opsonin-dependent phagocytosis (mannose receptor, β-glucan receptor, scavenger receptor) and that of receptors involved in the opsonin-dependent phagocytosis, namely the complement 3 (CR3) and the Fcγ receptors (FcγR). First, the molecular and cellular mechanisms induced when these receptors are conducting a phagocytic event are presented. In the second part, we will discuss the role these receptors may play in multiple sclerosis and Alzheimer's disease, in the elimination by phagocytosis of myelin and beta amyloid peptide respectively.

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The Role of β-Glucan Receptors on Blood and Tissue Leukocytes in Phagocytosis and Metabolic Activation

Cited by 80 publications

References 31 publications

Effects of Short- and Long-Term Glucan Feeding of Rainbow Trout (Salmonidae) on the Susceptibility to <I>Ichthyophthirius Multifiliis</I> Infections

Effects of Short- and Long-Term Glucan Feeding of Rainbow Trout (Salmonidae) on the Susceptibility to <I>Ichthyophthirius Multifiliis</I> Infections

Differential Adjuvant Effects of Soluble Beta Glucans from Barley and Saccharomyches Cerevisia in Primary and Secondary Humoral Immune Responses

Phagocytic functions of microglial cells in the central nervous system and their importance in two neurodegenerative diseases: multiple sclerosis and Alzheimer’s disease

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