The role of AMH in the reproductive system of women (a review)

Soghoyan, N. S.; Козаченко, И. Ф.; Adamyan, LV

doi:10.17116/repro201723137-42

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Между тем известно, что АМГ имеет тесную корреляционную связь с количеством ооцитов, полученных в результате стимуляции суперовуляции. Пациентки с низким уровнем АМГ стандартно слабо реагируют на стимуляцию и, следовательно, имеют низкую вероятность наступления беременности с собственными яйцеклетками [7][8][9].…”

Section: результаты и обсуждениеunclassified

Immunological and immunohistochemical features of endometrial implantation factor in healthy patients of late reproductive age

Кравцова

Колесникова

Lukoshkina

et al. 2023

Vestn. Ross. univ. družby nar., Ser. Med.

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Аbstract. Relevance. The number of women of older reproductive age is steadily increasing, and repeated failures of Assisted Reproductive Technologies programs during the transfer of high-quality embryos indicate the possibility of disruption of embryo implantation processes associated with impaired receptivity and functionality of the endometrium. Morphological, immunological and immunohistochemical changes in the endometrium associated with age factor may be decisive for the formation of the «implantation window» and correction of these changes and may improve the outcomes of Assisted Reproductive Technologies for a cohort of patients of older reproductive age. The aim of the study - to expand the pathogenetic understanding of the violation of the implantation ability of the endometrium in healthy patients of older reproductive age. Materials and Methods. A prospective sample study of 46 patients (group 1), aged 38 to 45 years with an officially registered diagnosis of infertility lasting no more than 4 years, with a successful gynecological and obstetric history, who were about to have their first IVF attempt, was conducted. The patients were examined according to Order № 803n of the Ministry of Health of the Russian Federation. Additionally, the level of peripheral blood melatonin, the determination of progesterone, estrogen, HLA-DR (MHC II), CD56 (NK cells), CD138, leukemia inhibiting factor receptors in the endometrium were studied. Concentrations of IL-6, IL-10, TGFß, and VGEF were determined in the cervical secretion, with the calculation of the pro-inflammatory index, as the ratio of IL-6/IL-10 cu and the ratio of TGFß1/VEGF. Statistical data processing was performed using the Statistica 10.0 application software package (StatSoft, Inc., USA). Results and Discussion. In the group of healthy patients of older reproductive age, there is an imbalance of steroid receptors and secretory transformation of the endometrium against the background of relative hyperestrogenism, with a decrease in the reception of own hormones in the endometrium. A decrease in melatonin signals a disorder of pineal and pituitary control over ovarian cycling. There is a decrease in the expression of leukemia inhibiting factor. Signs of inactive chronic endometritis with an autoimmune component are monitored, confirmed by a pro-inflammatory cytokine balance. The predominance of fibrosis processes over angiogenesis processes is confirmed by an increase in the ratio of TGFß1/VEGF and highly resistant blood flow in the uterine arteries. Conclusion. Standard pre-gravidar preparation cannot compensate for all factors that violate the implantation potential of the endometrium in this cohort of patients and requires the development of new complex techniques that directly affect the diversity of all factors that ensure the natural extinction of reproductive potential in order to increase the effectiveness of Assisted Reproductive Technologies programs.

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Section: результаты и обсуждениеunclassified

Immunological and immunohistochemical features of endometrial implantation factor in healthy patients of late reproductive age

Кравцова

Колесникова

Lukoshkina

et al. 2023

Vestn. Ross. univ. družby nar., Ser. Med.

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Importance of investigation of ovarian biopsy in assessing the ovarian reserve in infertile patients

Denisenko¹,

Курцер²,

Курило³

et al. 2017

Ross. vestn. akush.-ginekol.

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В мировой литературе сообщения о методах, определяющих состояние овариального резерва (ОР), стали появляться с конца 80-х годов XX века. В настоящее время интерес к изучению этого вопроса не ослабевает. Обсуждается роль новых факторов, возможно, способных наиболее точно отразить функциональное состояние яичников. Существуют следующие методы определения состояния овариального резерва:-гормональные тесты: базальный уровень ФСГ, соотношение ФСГ/ЛГ, базальный уровень эстрадиола; -ультразвуковой метод: измерение объема яичников, определение числа антральных фолликулов (ЧАФ), *e-mail: margarita_pmc@mail.ru; ORCID: http://orcid.org/0000-0002-9018-0994 допплерометрическое исследование кровотока в яичниках;-уровень антимюллерова гормона (АМГ); -подсчет числа фолликулов в биоптатах яичников. Влияние различных факторов на функциональное состояние яичников определяет значительную вариабельность биохимических и ультразвуковых характеристик, что нивелирует их диагностическую значимость в дефиниции ОР.В настоящее время для оценки состояния ОР в практике используют уровень АМГ в сыворотке крови [1].

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Ultrasound and Doplerometric Characteristics of Pelvic Organs in Women With Infertility and the History of Prenatal Stress

Semenenko

2021

WOMAB

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The role of AMH in the reproductive system of women (a review)

Cited by 3 publications

References 18 publications

Immunological and immunohistochemical features of endometrial implantation factor in healthy patients of late reproductive age

Immunological and immunohistochemical features of endometrial implantation factor in healthy patients of late reproductive age

Importance of investigation of ovarian biopsy in assessing the ovarian reserve in infertile patients

Ultrasound and Doplerometric Characteristics of Pelvic Organs in Women With Infertility and the History of Prenatal Stress

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