The role of altered cutaneous immune responses in the induction and persistence of rosacea

Margalit, Anatte; Kowalczyk, Michał; Żaba, Ryszard; Kavanagh, Kevin

doi:10.1016/j.jdermsci.2015.12.006

Cited by 40 publications

(39 citation statements)

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“…The excessive presence of B. olerinus near the eyelids triggers a cascade of events that may degenerate into chronic inflammation of the ocular surface. First, the immune system responds by orchestrating an army of proinflammatory agents, including antimicrobial peptides, toll-like receptors, cytokines, chemokines, and matrix metal-loproteinases (MMPs) 47,48. In small quantities, these agents may perform well.…”

Section: Eradicating Demodexmentioning

confidence: 99%

Intense pulsed light for evaporative dry eye disease

Dell¹

2017

OPTH

102

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There is a clear association between dry eye disease (DED) and skin inflammatory diseases occurring in close proximity to the eyelids, such as facial skin rosacea. Intense pulsed light (IPL) is widely accepted as a treatment for skin rosacea. A number of recent studies demonstrated that, in patients suffering from meibomian gland dysfunction (MGD), IPL therapy also reduces signs and symptoms of DED. Despite these encouraging results, in the context of DED and MGD, the mechanisms of action of IPL are not well understood. The purpose of this review was to raise the potential mechanisms of action and to discuss their plausibility.

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Section: Eradicating Demodexmentioning

confidence: 99%

Intense pulsed light for evaporative dry eye disease

Dell¹

2017

OPTH

102

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“…The exact cause of rosacea remains unclear. It may contain hereditary components, and has been hypothesized to be associated with disorders of the innate immune system, dysfunction of facial vascular regulation, neurogenic inflammation, and elevated levels of Demodex mites, among others (Gibson, 2004; Yamasaki & Gallo, 2009; Abram et al, 2010; Steinhoff et al, 2011; Van Zuuren et al, 2015; Margalit et al, 2016). Morbidity of rosacea varies greatly among different ethnic populations, with a higher prevalence amongst fair-skinned individuals of northern European or Celtic ancestry (Spoendlin et al, 2012; Tuzun et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

An observational descriptive survey of rosacea in the Chinese population: clinical features based on the affected locations

Xie

Huang

Yang

et al. 2017

PeerJ

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BackgroundThere is currently no study that has evaluated the differences in epidemiological and clinical characteristics among rosacea patients according to different facial sites.MethodsClinical and demographic data were obtained from 586 rosacea patients. The patients were divided into four groups based on the main sites involved with the rosacea lesions (full-face, cheeks, nose, or perioral involvement). Clinical signs were measured through self-reported, dermatologist-evaluated grading of symptoms, and physiological indicators of epidermal barrier function.ResultsThere were 471 (80.4%), 49 (8.4%), 52 (8.9%), and 14 (2.4%) cases in the full-face, cheek, nasal and perioral groups, respectively. Compared with the healthy control, the full-face group had lower water content and higher transepidermal water loss (TEWL) in the cheeks, and chin; the perioral group had lower water content and higher TEWL in the chin; while the nasal group had the normal water content and TEWL. Compared with the full-face group, the nasal group had more severe phymatous changes, less severe self-reported and dermatologist-evaluated grading of symptoms. All the patients in the perioral or the nasal group had their first rosacea lesions start and remain at the chin or on the nose. In the full-face group, 55.8% of patients had their lesions start with the full face, 40.1% on the cheek, and the rest (4.1%) on the nose.ConclusionSignificant differences in clinical features were observed among rosacea patients with lesions at four different sites. The lesion localization of each group was relatively stable and barely transferred to other locations.

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“…The fisher ranking applied favours the detection of larger groups over smaller subgroups, which is reasonable considering the limits of the presented meta‐analysis, yet definite molecular functions appeared highly enriched in the groups analysed. These were CCR chemokine receptor binding and chemokine activity, as well as serine and threonine endopeptidase supporting the pathological peptide‐based rosacea progression, and cellular factors involved in redox process which features rosacea phenotypes. Subtype‐specific rosacea genes (groups c1‐3) were analysed to emphasize the predominance of specific processes or functional groups.…”

Section: Resultsmentioning

confidence: 82%

Exploring the potential for rosacea therapeutics of siRNA dispersion in topical emulsions

Colombo¹,

Harmankaya

Water³

et al. 2019

Experimental Dermatology

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Rosacea is a prevalent skin condition dependent on the individual genetic profile. The current pharmacological management of this condition is mostly based on small molecule drugs predominately effective in ameliorating the inflammatory condition. Emerging molecular approaches could present an opportunity for managing rosacea conditions at transcriptomic level, and in the future allow personalized approaches. RNA medicines, such as small RNA interference (siRNA), could provide a flexible and applicable tool reaching this aim. However, the topical siRNA delivery by dermatological emulsions, commonly used in the daily management of rosacea, is still largely unexplored. Consequently, RNA interference application to rosacea was defined on molecular bases by genetic expression meta‐data analysis. Based on this, a siRNA directed against TLR2 was designed and validated in vitro on murine macrophages and fibroblasts. Next, siRNA was dispersed in the continuous phase of emulsions and was characterized for commonly used dermatologic bases. Finally, the potential delivery performance of the topical emulsions was tested in vivo on healthy Balb/c mice. It was found that the interaction of siRNA with combination of excipients, such as urea and glycerol, is likely to favour the siRNA delivery, inducing genetic silencing of TLR2. These findings provide a foundation for the future development of topical RNA‐based dispersions for topical molecular medicines, by emphasizing on the formulation and therapeutic‐based opportunities with dermatological treatments.

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The role of altered cutaneous immune responses in the induction and persistence of rosacea

Cited by 40 publications

References 50 publications

Intense pulsed light for evaporative dry eye disease

Intense pulsed light for evaporative dry eye disease

An observational descriptive survey of rosacea in the Chinese population: clinical features based on the affected locations

Exploring the potential for rosacea therapeutics of siRNA dispersion in topical emulsions

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