The role of allopregnanolone in the anxiolytic-like effect of free and easy wanderer plus (FEWP), a polyherbal preparation

Translocator protein mediates the anxiolytic and antidepressant effects of midazolam

“…The anxiolytic effect is indicated by an increase in the number of shocks that the rats receive following inhibition of the conflict between the desire to drink water and aversion to an electric shock (Kasahara et al, 2015;Qiu et al, 2015). The test was performed as described previously (Zhang et al, 2014a).…”

Jiawei Xiaoyao San in treatment of anxiety disorder and anxiety: A review

“…Besides, the administration of JWXYS (5 and 10 mg/kg, p.o.) increased allopregnanolone levels in the prefrontal cortex and hippocampus ( Qiu et al, 2015 ). Reduced levels of allopregnanolone in the peripheral blood or cerebrospinal fluid were found to be associated with major depression, anxiety disorders, premenstrual dysphoric disorder, negative symptoms in schizophrenia, or impulsive aggression.…”