The Role of Allergen-Specific Immunotherapy in ENT Diseases: A Systematic Review

Cantone, Elena; Gallo, Stefania; Torretta, Sara; Detoraki, Aikaterini; Cavaliere, Carlo; Nola, Claudio Di; Spirito, Luca; Cesare, Tiziana Di; Settimi, Stefano; Furno, Daniela; Corso, Eugenio De

doi:10.3390/jpm12060946

Cited by 6 publications

(8 citation statements)

References 121 publications

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“…Subcutaneous immunotherapy (SCIT) or sublingual immunotherapy (SLIT) against pollen is strongly recommended for seasonal allergic rhinitis induced by pollen. 93 For pollen-induced asthma, SCIT reduces asthma symptoms and asthma medications, with lower evidence for SLIT. 94 However, it is a key question whether the changes in pollen allergenicity will affect the efficacy of immunotherapy.…”

Section: What Is Known About Therapy and Prevention For Pollen Asthma?mentioning

confidence: 99%

“…Other therapies such as anti‐IL5/IL5Rα receptor or anti‐IL4Rα antibodies may also be considered with evidence of Type 2 inflammation. Subcutaneous immunotherapy (SCIT) or sublingual immunotherapy (SLIT) against pollen is strongly recommended for seasonal allergic rhinitis induced by pollen 93 . For pollen‐induced asthma, SCIT reduces asthma symptoms and asthma medications, with lower evidence for SLIT 94 .…”

Section: State Of Artmentioning

confidence: 99%

See 1 more Smart Citation

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Annesi‐Maesano

Cecchi

Biagioni

et al. 2023

Allergy

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Limited number of studies have focused on the impact of pollen exposure on asthma. As a part of the EAACI Guidelines on Environment Science, this first systematic review on the relationship of pollen exposure to asthma exacerbations aimed to bridge this knowledge gap in view of implementing recommendations of prevention. We searched electronic iPubMed, Embase, and Web of Science databases using a set of MeSH terms and related synonyms and identified 73 eligible studies that were included for systemic review. When possible, meta‐analyses were conducted. Overall meta‐analysis suggests that outdoor pollen exposure may have an effect on asthma exacerbation, but caution is needed due to the low number of studies and their heterogeneity. The strongest associations were found between asthma attacks, asthma‐related ED admissions or hospitalizations, and an increase in grass pollen concentration in the previous 2‐day overall in children aged less than 18 years of age. Tree pollen may increase asthma‐related ED visits or admissions lagged up to 7‐day overall in individuals younger than 18 years. Rare data show that among subjects under 18 years of age, an exposure to grass pollen lagged up to 3 days may lower lung function. Further research considering effect modifiers of pollen sensitization, hay fever, asthma, air pollution, green spaces, and pre‐existing medications is urgently warranted to better evaluate the impacts of pollen on asthma exacerbation. Preventive measures in relation to pollen exposure should be integrated in asthma control as pollen increase continues due to climate change.

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Section: What Is Known About Therapy and Prevention For Pollen Asthma?mentioning

confidence: 99%

Section: State Of Artmentioning

confidence: 99%

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Annesi‐Maesano

Cecchi

Biagioni

et al. 2023

Allergy

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“…It has been suggested that the comorbid AR and its associated type 2 inflammatory response may amplify the CRS disease process. 21 Several prospective studies have shown that the addition of allergen immunotherapy to standard CRS treatment is associated with decreased nasal symptom scores, improved radiologic outcome scores, and, in one study, a 54% decrease in sinus surgeries. [21][22][23]…”

Section: Ar and Crswnpmentioning

confidence: 99%

“…21 Several prospective studies have shown that the addition of allergen immunotherapy to standard CRS treatment is associated with decreased nasal symptom scores, improved radiologic outcome scores, and, in one study, a 54% decrease in sinus surgeries. [21][22][23]…”

Section: Ar and Crswnpmentioning

confidence: 99%

Understanding the CRSwNP Patient as Whole

Bandi

Stephen

Bansal

et al. 2023

Am J Rhinol�Allergy

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Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a distinct inflammatory disease of the upper airways with a significant impact on the health and quality of life of affected patients. Several comorbid conditions such as allergic rhinitis, asthma, sleep disorders, and gastroesophageal reflux disease are commonly reported in patients with CRSwNP. Objective In this article, we intended to review the UpToDate information on how these comorbidities can impact CRSwNP patients’ health and well-being. Methods A PUBMED search was performed to review relevant recent article on the topic. Results While there have been significant advances in the knowledge and management options for CRSwNP in the past few years, additional studies are needed to understand the underlying pathophysiologic mechanisms of these associations. In addition, awareness of the impact of CRSwNP on mental health, quality of life, and cognition is paramount to treating this condition. Conclusion Recognition and addressing CRSwNP comorbidities such as allergic rhinitis, asthma, sleep disorders, gastroesophageal reflux disease, and cognitive function impairment are important to optimally understand and manage the patient with CRSwNP as a whole.

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“…Some factors, such as allergy and infection, are thought to be involved in the development of OME. 8 Therefore, atopic condition and infection are probably the risk factors of OME in children with AH and it is warranted to further study.…”

Section: Introductionmentioning

confidence: 98%

Analysis of Risk Factors for Otitis Media with Effusion in Children with Adenoid Hypertrophy

Yang¹,

Jv²,

Zhang³

et al. 2023

RMHP

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Objective This study aimed to explore whether children with AH have a higher obesity prevalence and analyze the risk factors for otitis media with effusion(OME) in AH children. Methods AH patients aged 3–12 years old that were hospitalized in our hospital for adenoidectomy from June 2020 to September 2022 were included in this study. Height and weight were measured to calculate the body mass index, weight for height and weight z-score to evaluate the development of AH children. Propensity score matching was applied to minimize patient selection bias and adjust for confounding factors to analyze the risk factors for OME in children with AH. Results A total of 887 children with AH were enrolled in this study. The prevalence of overweight or obesity was higher in children with AH than the control group. The size of adenoids is significantly different between AH children with and without OME. For children aged over 5, there are significantly higher counts of white blood cells, neutrophils, and monocytes in the AH children with OME than those without OME. More individuals represent to be atopic in children with OME than those without OME. Conclusion The obstruction of the Eustachian tube is the most important factor of OME in AH children. It seems that there is no apparent correlation between OME and atopic conditions in AH children. In addition to surgical resection of adenoids, active control of infection and inflammation are also important to prevent OME for AH children aged over 5.

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The Role of Allergen-Specific Immunotherapy in ENT Diseases: A Systematic Review

Cited by 6 publications

References 121 publications

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Understanding the CRSwNP Patient as Whole

Analysis of Risk Factors for Otitis Media with Effusion in Children with Adenoid Hypertrophy

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