Understanding the CRSwNP Patient as Whole

Abstract

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a distinct inflammatory disease of the upper airways with a significant impact on the health and quality of life of affected patients. Several comorbid conditions such as allergic rhinitis, asthma, sleep disorders, and gastroesophageal reflux disease are commonly reported in patients with CRSwNP. Objective In this article, we intended to review the UpToDate information on how these comorbidities can impact CRSwNP patients’ health and well-being. Methods A PUBMED search was performed to review relevant recent article on the topic. Results While there have been significant advances in the knowledge and management options for CRSwNP in the past few years, additional studies are needed to understand the underlying pathophysiologic mechanisms of these associations. In addition, awareness of the impact of CRSwNP on mental health, quality of life, and cognition is paramount to treating this condition. Conclusion Recognition and addressing CRSwNP comorbidities such as allergic rhinitis, asthma, sleep disorders, gastroesophageal reflux disease, and cognitive function impairment are important to optimally understand and manage the patient with CRSwNP as a whole.

Adherence to Intranasal Steroids in Chronic Rhinosinusitis with Nasal Polyposis Prior to and during Biologic Therapy: A Neglected Matter

“…Its prevalence in the general population is estimated to be around 3-4% with a variability based on geographical area, but it increases to 40-60% in patients suffering from severe eosinophilic asthma [10,11]. Though this is not a life-threatening condition, it heavily impacts the quality of life of affected patients, particularly because of the nasal obstruction with concomitant hypo/anosmia and sleep disturbances it causes [12]. Interestingly, a similar scenario can be observed in this condition compared to asthma regarding the adherence to therapy, specifically about the use of intranasal corticosteroids (INCS).…”