The Role of Alcoholic Intake in Esophageal Carcinoma

Kamionkowski, Mario D.; Fleshler, Bertram

doi:10.1097/00000441-196506000-00011

Cited by 23 publications

(4 citation statements)

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“…Mossbach and Viddeback (17) have reported that 65% of 84 male esophageal cancer patients were alcoholics, and 21% of them were employed as brewery workers. In other studies it has been shown that the risk of the disease is 17 times greater for alcoholics than nonalcoholics (18). In France and in some parts of Africa, esophageal cancer appears to correlate to the type of alcoholic beverage more than to the amount that is consumed, suggesting some type of contaminant.…”

Section: Esophageal Carcinogenesismentioning

confidence: 82%

Promotion of Gastrointestinal Tract Tumors in Animals: Dietary Factors

Newberne¹,

Schrager²

1983

Environmental Health Perspectives

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Section: Esophageal Carcinogenesismentioning

confidence: 82%

Promotion of Gastrointestinal Tract Tumors in Animals: Dietary Factors

Newberne¹,

Schrager²

1983

Environmental Health Perspectives

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“…19,20) Development of esophageal squamous cell carcinomas has been associated with increased exposure to exogenous factors, such as smoking and drinking of alcohol. [25][26][27] Many carcinogens are detoxified by conjugation with GSH, catalyzed by GSTs. The etiology of squamous cell carcinoma is complex and multifactorial and there is little evidence for progression to cancer via intermediate premalignant lesions such as dysplasia, which hampers early detection.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Localization of Glutathione S‐Transferase α and π in Human Esophageal Squamous Epithelium, Barrett's Epithelium and Carcinoma

Lieshout

Haelst

Wobbes

et al. 1999

Japanese Journal of Cancer Research

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High tissue levels of glutathione S-transferases (GSTs), a family of detoxification enzymes, are inversely correlated with cancer risk in the human gastrointestinal tract. Patients with Barrett's esophagus, wherein squamous epithelium is replaced by columnar epithelium, have an increased risk for developing esophageal adenocarcinoma. Biochemical analyses revealed that Barrett's epithelium contains lower levels of GST enzyme activity as well as some GST isoforms, as compared with squamous epithelium. So far, little information on the immunohistochemical distribution of the GST α α α α and π π π π isoforms in normal squamous epithelium, in Barrett's metaplastic epithelium or in adeno-and squamous cell carcinomas of the esophagus is available. Tissues were fixed in formalin and embedded in paraffin. Three 4 µ µ µ µm thick sections were used for hematoxylin and eosin staining and for immunostaining with antibodies against GST α α α α and π π π π. GST α α α α and π π π π were seen in normal squamous epithelium (0% and 75%, respectively), Barrett's epithelium (75% and 100%), adenocarcinoma (25% and 100%) and squamous cell carcinoma (27% and 91%). Staining was mainly cytoplasmic, though some nuclear staining with the GST π π π π antibody was apparent. The varying expression of GST α α α α and π π π π in normal and (pre)neoplastic esophagus may have consequences for the treatment of these diseases and may contribute to an understanding of the development of these esophageal disorders.

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“…Eine Reihe von Beobachtungen machen diesen Zusammenhang wahrscheinlich. Das Ösophaguskarzinom überwiegt nach Angaben verschiedener Autoren beim männlichen Geschlecht mit dem durchschnittlich höheren Alkoholkonsum gegenüber Frauen um etwa das Vierfache (21,58 (21). Außerdem fanden sich bei Juden, die bekanntlich nur sehr geringe Mengen von Alkohol konsumieren, erheblich weniger Ösophaguskarzinome als bei anderen Bevölkerungsgruppen (21).…”

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“…Das Ösophaguskarzinom überwiegt nach Angaben verschiedener Autoren beim männlichen Geschlecht mit dem durchschnittlich höheren Alkoholkonsum gegenüber Frauen um etwa das Vierfache (21,58 (21). Außerdem fanden sich bei Juden, die bekanntlich nur sehr geringe Mengen von Alkohol konsumieren, erheblich weniger Ösophaguskarzinome als bei anderen Bevölkerungsgruppen (21). Schließlich sei noch auf Beobachtungen aus Zentralafrika hingewiesen, wo in bestimmten geographischen Bezirken mit einem relativ hohen Alkoholkonsum Ösophaguskarzinome gehäuft auftreten (30).…”

unclassified

Akute und chronische Alkoholschäden im Bereich des Gastrointestinaltraktes

Ha¹,

Ga²

1975

Dtsch med Wochenschr

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The Role of Alcoholic Intake in Esophageal Carcinoma

Cited by 23 publications

References 0 publications

Promotion of Gastrointestinal Tract Tumors in Animals: Dietary Factors

Promotion of Gastrointestinal Tract Tumors in Animals: Dietary Factors

Immunohistochemical Localization of Glutathione S‐Transferase α and π in Human Esophageal Squamous Epithelium, Barrett's Epithelium and Carcinoma

Akute und chronische Alkoholschäden im Bereich des Gastrointestinaltraktes

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