The role of adipokines in the pathogenesis of gestational diabetes mellitus

Gennaro, Giovanni; Palla, Giulia; Battini, Lorella; Simoncini, Tommaso; Prato, Stefano Del; Bertolotto, Alessandra; Bianchi, Cristina

doi:10.1080/09513590.2019.1597346

Cited by 55 publications

(69 citation statements)

References 134 publications

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“…In a recent review of clinical studies investigating the relationship between apelin and GDM, nearly all of the studies showed that lower apelin levels occurred in women with GDM compared to those without GDM. However, a few studies reported that the level of apelin-36 was increased in GDM [18].…”

Section: Discussionmentioning

confidence: 99%

“…Omentin, or intelectin-1, is an adipokine consisting of 313 amino acids primarily secreted from visceral adipose tissue, but it is also expressed in the heart, placenta, and ovaries [17]. Adipokines likely influence GDM; however, data on the roles of apelin, chemerin, and omentin in GDM are limited and inconsistent [18]. The aim of this study was to systematically evaluate the correlations between the serum levels of such adipokines and GDM.…”

Section: Introductionmentioning

confidence: 99%

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Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

et al. 2020

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Background: The available data on the significance of circulating apelin, chemerin and omentin in women with gestational diabetes mellitus (GDM) are inconsistent. This analysis includes a systematic review of the evidence associating the serum concentrations of these adipokines with GDM. Methods: Publications through December 2019 were retrieved from PubMed, Embase, the Cochrane Library, and Web of Science. Subgroup analysis and meta-regression were conducted to evaluate sources of heterogeneity. Results: Analysis of 20 studies, including 1493 GDM patients and 1488 normal pregnant women did not find significant differences in circulating apelin and chemerin levels (apelin standardized mean difference [SMD] = 0.43, 95% confidence interval (CI): − 0.40 to 1.26, P = 0.31; chemerin SMD = 0.77, 95% CI − 0.07 to 1.61, P = 0.07). Circulating omentin was significantly lower in women with GDM than in healthy controls (SMD = − 0.72, 95% CI − 1.26 to − 0.19, P = 0.007). Publication bias was not found; sensitivity analysis confirmed the robustness of the pooled results. Conclusions: Circulating omentin was decreased in GDM patients, but apelin and chemerin levels were not changed. The results suggest that omentin has potential as a novel biomarker for the prediction and early diagnosis of GDM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

et al. 2020

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“…Ning et al (17), reported that FABP4 was overexpressed in GDM patients and has a significant positive correlation with IR and inflammatory factor TNF-α, suggesting that FABP4 can be used as a new biomarker for GDM. Chemerin and FABP4 are both inflammatory adipocyte factors expressed in adipocytes, both of which are related to the development and progression of GDM (18).…”

Section: Introductionmentioning

confidence: 99%

Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients

Wang

Liu²,

Wang

et al. 2019

Exp Ther Med

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Expression and correlation of Chemerin and fatty acid-binding protein 4 (FABP4) in peripheral blood of gestational diabetes mellitus (GDM) patients were investigated. Sixty patients with GDM from March 2018 to March 2019 in the People's Hospital of Zhangqiu Area were selected as the study group (SG) and another 50 healthy pregnant women corresponding to their age and pregnancy were selected as the control group (CG). Enzyme linked immunosorbent assay (ELISA) was used to detect the expression of Chemerin and FABP4 in serum. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of Chemerin and FABP4 in peripheral blood for GDM patients. Pearson's correlation coefficient was used to analyze the correlation between Chemerin and FABP4 and the correlation between Chemerin and inflammatory factors such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Expression of Chemerin and FABP4 in peripheral blood of GDM patients were significantly higher than those in CG. The AUC of GDM patients diagnosed with Chemerin and FABP4 in peripheral blood was 0.820 and 0.814, while the AUC of GDM patients diagnosed with Chemerin combined with FABP4 in peripheral blood was 0.904. Expression of inflammatory factors IL-6 and TNF-α in the SG were significantly higher than those in the CG. Chemerin in the SG was positively correlated with FABP4 and positively correlated with inflammatory factors IL-6 and TNF-α. Patients with advanced age (≥35 years), family history of diabetes, hyperlipidemia, high pre-pregnancy BMI, high fasting blood glucose, high Chemerin and high FABP4 expression have high risk of GDM. In conclusion, Chemerin and FABP4 were upregulated in the peripheral blood of GDM patients. There was a positive correlation between the two and a positive correlation with the inflammatory factors IL-6 and TNF-α.

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“…The etiology of GDM is still unclear; however, numerous evidence has shown that GDM is a multifactorial disease, and its pathogenesis might be related to genetic factors, lifestyle, chronic inflammation and adipokines 5,6 . As a temporary organ formed during pregnancy, the placenta is not just the only interface connecting the mother and fetus, participating in the process of nutrient transport, gas exchange and blood circulation, but also has important endocrine functions.…”

Section: Introductionmentioning

confidence: 99%

Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus

Tang

2020

J of Diabetes Invest

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Aims/Introduction Non‐coding ribonucleic acids (ncRNAs) have recently been shown to be involved in various biological processes. However, most of these ncRNAs are of unknown function or without annotation. This study first investigated the whole transcriptome profiles of placentas to identify the potential functions that ncRNAs exerted in gestational diabetes mellitus (GDM). Materials and Methods Six placenta samples from healthy pregnant women (n = 3) and GDM (n = 3) were collected to analyze the whole transcriptome profiles by high‐throughput sequencing. Differentially expressed ncRNAs were further validated by quantitative real‐time polymerase chain reaction on an independent set of normal (n = 20) and GDM (n = 20) placenta samples. Results A total of 2,817 microRNAs (miRNAs), 23,339 long non‐coding RNAs (lncRNAs) and 9,513 circular RNAs (circRNAs) were identified. There were 290 differentially expressed ncRNAs in GDM placentas compared with the placentas of healthy pregnant women. Two miRNAs, 86 lncRNAs and 55 circRNAs were upregulated, while two miRNAs, 86 lncRNAs and 59 circRNAs were downregulated in GDM. The expression of the selected ncRNAs, which were further validated by quantitative real‐time polymerase chain reaction, was consistent with the sequencing results. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that the major targets of these ncRNAs were associated with insulin resistance, and abnormal glucose and lipid metabolism. A GDM‐related competing endogenous RNA network suggested the interactions between lncRNAs, circRNAs, messenger RNAs and miRNAs. Conclusions The whole transcriptome profiles significantly differed in GDM placentas compared with the placentas of healthy pregnant women, which might be valuable for detecting novel ncRNAs, and providing new research insights into exploring the pathogenic mechanisms of GDM.

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The role of adipokines in the pathogenesis of gestational diabetes mellitus

Cited by 55 publications

References 134 publications

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients

Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus

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