Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients

Wang, Xueling; Liu, Juanjuan; Wang, Dongqing; Zhu, Honghua; Kang, Le; Jiang, Juan

doi:10.3892/etm.2019.8247

Cited by 15 publications

(22 citation statements)

References 30 publications

(26 reference statements)

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“…This link between GDM and two members of the sFRP protein family implicates a role of the Wnt signaling pathway in impaired glucose tolerance. Furthermore, our results are in concordance with previous studies that showed decreased Adiponectin concentrations [37,38,61] and increased Chemerin and Leptin concentrations [32,36,41,62] in the first trimester of pregnancy in women who later developed GDM. In contrast to T2DM, it is proposed that GDM has a hormonal and autoimmunological background as underlying pathological mechanism [6][7][8][9][10][11][12].…”

Section: Plos Onesupporting

confidence: 93%

“…Adiponectin is an adipocytokine abundantly present in the circulation and involved in regulating glucose concentrations as well as fatty acid breakdown [39,40]. Moreover, higher Chemerin and Leptin concentrations during early pregnancy have also been shown to be associated with the development of GDM suggesting that these two adipocytokines can also be used as predictive biomarkers of GDM [32,41]. Chemerin modulates adipogenesis and immune system functions by binding to its own receptor [42][43][44].…”

Section: Introductionmentioning

confidence: 99%

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First trimester secreted Frizzled-Related Protein 4 and other adipokine serum concentrations in women developing gestational diabetes mellitus

et al. 2020

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Background The aim of this study was to evaluate whether soluble frizzled-related protein 4 (sFRP4) concentration in the first trimester of pregnancy is individually, or in combination with Leptin, Chemerin and/or Adiponectin, associated with the development of gestational diabetes (GDM). Methods In a nested case-control study, 50 women with GDM who spontaneously conceived and delivered a live-born infant were matched with a total of 100 uncomplicated singleton control pregnancies based on body mass index (± 2 kg/m2), gestational age at sampling (exact day) and maternal age (± 2 years). In serum samples, obtained between 70–90 days gestational age, sFRP4, Chemerin, Leptin and Adiponectin concentrations were determined by ELISA. Statistical comparisons were performed using univariate and multi-variate logistic regression analysis after logarithmic transformation of the concentrations. Discrimination of the models was assessed by the area under the curve (AUC). Results First trimester sFRP4 concentrations were significantly increased in GDM cases (2.04 vs 1.93 ng/ml; p<0.05), just as Chemerin (3.19 vs 3.15 ng/ml; p<0.05) and Leptin (1.44 vs 1.32 ng/ml; p<0.01). Adiponectin concentrations were significantly decreased (2.83 vs 2.94 ng/ml; p<0.01) in GDM cases. Further analysis only showed a weak, though significant, correlation of sFRP4 with Chemerin (R2 = 0.124; p<0.001) and Leptin (R2 = 0.145; p<0.001), and Chemerin with Leptin (R2 = 0.282; p<0.001) in the control group. In a multivariate logistic regression model of these four markers, only Adiponectin showed to be significantly associated with GDM (odds ratio 0.12, 95%CI 0.02–0.68). The AUC of this model was 0.699 (95%CI 0.605–0.793). Conclusion In the first trimester of pregnancy, a multi-marker model with sFRP4, Leptin, Chemerin and Adiponectin is associated with the development of GDM. Therefore, this panel seems to be an interesting candidate to further evaluate for prediction of GDM in a prospective study.

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Section: Plos Onesupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

First trimester secreted Frizzled-Related Protein 4 and other adipokine serum concentrations in women developing gestational diabetes mellitus

et al. 2020

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“…Whereas some authors did not observe any significant correlations between those parameters [ 177 ], the others found that chemerin values were positively markedly correlated with HOMA-IR or insulin levels [ 172 , 179 , 180 , 181 ]. Chemerin values were also found to be positively correlated with fatty acid-binding protein 4, interleukin-6, and tumor necrosis factor-α [ 182 ].…”

Section: Clinical Applications Of Adipokines Measurements In Variomentioning

confidence: 99%

“…To analyze its utility in the prediction of GDM, it is crucial to evaluate its blood concentrations in patients with GDM and healthy individuals. Some authors found that chemerin concentrations in peripheral blood are significantly increased throughout the pregnancy in patients with GDM [ 172 , 177 , 179 , 182 , 183 , 184 , 185 ]. Whereas some studies reported that chemerin levels are also significantly elevated in the cord blood samples [ 172 , 186 ], the others did not find any differences [ 187 ].…”

Section: Clinical Applications Of Adipokines Measurements In Variomentioning

confidence: 99%

“…Nonetheless, it is noteworthy that first and second trimester multiple regression models revealed that chemerin values are positively associated with the elevated risk of GDM, and along with other parameters, chemerin may be treated as an independent risk factor of GDM [ 177 , 182 , 184 , 193 ]. The implementation of the results of chemerin levels measurement improves the predictive values of models used in the prediction of GDM [ 177 , 182 ]. Finally, it is unlikely that its concentration measurement could be used as a single early marker in the prediction of GDM.…”

Section: Clinical Applications Of Adipokines Measurements In Variomentioning

confidence: 99%

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The Role of the Adipokines in the Most Common Gestational Complications

Gutaj

Sibiak

Jankowski

et al. 2020

IJMS

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Adipocytokines are hormonally active molecules that are believed to play a key role in the regulation of crucial biological processes in the human body. Numerous experimental studies established significant alterations in the adipokine secretion patterns throughout pregnancy. The exact etiology of various gestational complications, such as gestational diabetes, preeclampsia, and fetal growth abnormalities, needs to be fully elucidated. The discovery of adipokines raised questions about their potential contribution to the molecular pathophysiology of those diseases. Multiple studies analyzed their local mRNA expression and circulating protein levels. However, most studies report conflicting results. Several adipokines such as leptin, resistin, irisin, apelin, chemerin, and omentin were proposed as potential novel early markers of heterogeneous gestational complications. The inclusion of the adipokines in the standard predictive multifactorial models could improve their prognostic values. Nonetheless, their independent diagnostic value is mostly insufficient to be implemented into standard clinical practice. Routine assessments of adipokine levels during pregnancy are not recommended in the management of both normal and complicated pregnancies. Based on the animal models (e.g., apelin and its receptors in the rodent preeclampsia models), future implementation of adipokines and their receptors as new therapeutic targets appears promising but requires further validation in humans.

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Proteins and metabolites fingerprints of gestational diabetes mellitus forming protein–metabolite interactomes are its potential biomarkers

Chatterjee

Thakur

2023

Proteomics

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Gestational diabetes mellitus (GDM) is a consequence of glucose intolerance with an inadequate production of insulin that happens during pregnancy and leads to adverse health consequences for both mother and fetus. GDM patients are at higher risk for preeclampsia, and developing diabetes mellitus type 2 in later life, while the child born to GDM mothers are more prone to macrosomia, and hypoglycemia. The universally accepted diagnostic criteria for GDM are lacking, therefore there is a need for a diagnosis of GDM that can identify GDM at its early stage (first trimester). We have reviewed the literature on proteins and metabolites fingerprints of GDM. Further, we have performed protein-protein, metabolite-metabolite, and protein-metabolite interaction network studies on GDM proteins and metabolites fingerprints. Notably, some proteins and metabolites fingerprints are forming strong interaction networks at high confidence scores. Therefore, we have suggested that those proteins and metabolites that are forming protein-metabolite interactomes are the potential biomarkers of GDM. The protein-metabolite biomarkers interactome may help in a deep understanding of the prognosis, pathogenesis of GDM, and also detection of GDM. The protein-metabolites interactome may be further applied in planning future therapeutic strategies to promote long-term health benefits in GDM mothers and their children.

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Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients

Cited by 15 publications

References 30 publications

First trimester secreted Frizzled-Related Protein 4 and other adipokine serum concentrations in women developing gestational diabetes mellitus

First trimester secreted Frizzled-Related Protein 4 and other adipokine serum concentrations in women developing gestational diabetes mellitus

The Role of the Adipokines in the Most Common Gestational Complications

Proteins and metabolites fingerprints of gestational diabetes mellitus forming protein–metabolite interactomes are its potential biomarkers

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