The role of adenosine 3′,5′-phosphate in the action of antidiuretic hormone

Orloff, Jack; Handler, Jerome S.

doi:10.1016/0002-9343(67)90093-9

Cited by 338 publications

(94 citation statements)

References 49 publications

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“…Kidney V2 receptors interact with adenylyl cyclase to increase intracellular cyclic adenosine monophosphate (cAMP) and cause retention of water. 61 This interaction occurs through the coupling of the receptor with the s subunit of the G protein complex. 13 V3 pituitary receptors (formerly known as V1b) have central effects, such as increasing adrenocorticotropic hormone (ACTH) production, activating different G proteins, and increasing intracellular cAMP.…”

Section: Vasopressin Receptorsmentioning

confidence: 99%

Physiology of Vasopressin Relevant to Management of Septic Shock

Holmes

Patel

Russell

et al. 2001

Chest

530

395

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Section: Vasopressin Receptorsmentioning

confidence: 99%

Physiology of Vasopressin Relevant to Management of Septic Shock

Holmes

Patel

Russell

et al. 2001

Chest

530

395

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“…The nucleotide cyclic 3',5'-AMP is the putative intracellular mediator of ADH action (Orloff & Handler, 1967). The 0 Minutes Fig.…”

Section: Adh Action On Frog Skinmentioning

confidence: 99%

Independent action of antidiuretic hormone, theophylline and cyclic 3′,5′‐adenosine monophosphate on cell membrane permeability in frog skin

Cuthbert¹,

Painter²

1968

The Journal of Physiology

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1. The effects of antidiuretic hormone (ADH), theophylline and cyclic 3′,5′‐adenosine monophosphate (AMP) on membrane potentials in frog skin have been investigated. 2. Membrane potentials across the outer and inner facing membranes were recorded in both normal and current clamped skins. In the latter condition active transport of sodium had been abolished by ouabain or metabolic inhibitors, but ionic gradients were maintained by passing current through the skin from the inside. 3. ADH increases the potential across the outer facing membranes and reduces the skin resistance. The results are consistent with ADH causing an increase in permeability of the outer facing membranes to sodium ions. 4. Theophylline reduces the skin potential by reducing specifically the potential across the outer facing membranes. At the same time the skin resistance is reduced. Theophylline acts by increasing the permeability of the outer facing membranes to chloride ions. 5. Cyclic 3′,5′‐AMP causes a biphasic potential change accompanied by an increase in skin resistance. 6. Metabolic inhibitors block the response of the skin to ADH but not to theophylline. 7. Separate explanations for the increase in sodium transport by ADH, theophylline and cyclic 3′,5′‐AMP are discussed. It is not necessary to involve cyclic AMP in order to explain the effects of either ADH or theophylline.

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“…Vasopressin, like other peptide hormones, exerts its physiological function by binding to cell-surface receptors in association with a specific guanine nncleotide-binding protein (2). These actions in the kidney are mediated by the adenylate cyclase-coupled V 2 -receptor subtype.…”

Section: Introductionmentioning

confidence: 99%