2002
DOI: 10.1634/stemcells.20-6-493
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The Role of Activin A in Regulation of Hemopoiesis

Abstract: Activin A, a cytokine member of the transforming growth factor-β superfamily, is expressed locally by the mesenchymal component of the hemopoietic microenvironment. Its expression is regulated on the mRNA level by different cytokines, and the biological activity of the protein is tightly controlled by several inhibitory molecules. Activin A affects hemopoietic cells of various lineages, as evidenced by in vitro studies of leukemia and lymphoma cell lines, which were used to elucidate the mechanism of its actio… Show more

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Cited by 62 publications
(15 citation statements)
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“…Type 1 collagen, the main osteogenic collagen was not amongst the regulated genes, however, multiple other osteogenic markers genes including aggrecan (ACAN), sparc/osteonectin (SPOCK1), osteoblast cadherin (CDH11) and Wnt pathway members Frizzled homologue-8 (FZD8) and Secreted frizzled related protein 4 (SFRP4) were induced in parallel with decreased expression of the negative osteogenic regulator osteocrin (Tables 2 and 3 ) [ 52 , 53 ]. Four of the most strongly induced genes including early growth response 2 (EGR2 > 6-fold) [ 54 ], interleukin 11 (Il-11 > 5-fold), growth differentiation factor 6 (GDF6 > 5-fold) and hemopoietic cell kinase (HCK ~5-fold) as well as activin-A receptor (2-fold [ 55 ]) are associated with hematopoiesis. Transcript levels of multiple genes associated with angiogenesis were increased by hypoxia [ 56 ] while there were marked decreases of multiple striated muscle markers (Tables 2 and 3 ).…”
Section: Resultsmentioning
confidence: 99%
“…Type 1 collagen, the main osteogenic collagen was not amongst the regulated genes, however, multiple other osteogenic markers genes including aggrecan (ACAN), sparc/osteonectin (SPOCK1), osteoblast cadherin (CDH11) and Wnt pathway members Frizzled homologue-8 (FZD8) and Secreted frizzled related protein 4 (SFRP4) were induced in parallel with decreased expression of the negative osteogenic regulator osteocrin (Tables 2 and 3 ) [ 52 , 53 ]. Four of the most strongly induced genes including early growth response 2 (EGR2 > 6-fold) [ 54 ], interleukin 11 (Il-11 > 5-fold), growth differentiation factor 6 (GDF6 > 5-fold) and hemopoietic cell kinase (HCK ~5-fold) as well as activin-A receptor (2-fold [ 55 ]) are associated with hematopoiesis. Transcript levels of multiple genes associated with angiogenesis were increased by hypoxia [ 56 ] while there were marked decreases of multiple striated muscle markers (Tables 2 and 3 ).…”
Section: Resultsmentioning
confidence: 99%
“…Further, TP53 has been shown to modulate CDK4/RB1 through CDKN1A in human colon cancer cells [77]. TP53 can increase the expression of CDKN1A, which in turn decreases phosphorylation of RB1 [78]. Additionally, CDKN1A may also decrease phosphorylation of RB1 via CDK2-Cyclin D1 complex [79].…”
Section: Resultsmentioning
confidence: 99%
“…A distinct role for TGF-β and activin in erythropoiesis has been reported in studies of primary and transformed cells [16-28,30-32,36,49,50]. However, given the many stages of erythropoiesis from the stem cell quiescence to red cell enucleation and the many cytokines involved, these studies cannot be fully informative about the context in which signaling networks co-mediate TGF-β/activin effects [8,9].…”
Section: Discussionmentioning
confidence: 99%
“…TGF-β and activin both regulate different cellular events of hematopoiesis in a lineage specific manner [26-28]. Both cytokines stimulate erythroid differentiation, accompanied by hemoglobin synthesis, and TGF-β inhibited growth of early but not late erythroid progenitor cells [26,29-32].…”
Section: Introductionmentioning
confidence: 99%