The role of active brown adipose tissue in human metabolism

Özgüven, Salih; Öneş, Tunç; Yılmaz, Yusuf; Turoğlu, Halil Turgut; İmeryüz, Neşe

doi:10.1007/s00259-015-3166-7

Cited by 24 publications

(25 citation statements)

References 25 publications

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“…The results of this study were partially consistent with previous studies [21]. However, we also showed that serum TG level in aBAT group was lower than that of the control group, which is different from other studies [11, 21]. …”

Section: Discussionsupporting

confidence: 83%

“…Van Marken et al [22] showed that subjects with BMI of 38.7 kg/m 2 did not exhibit BAT imaging even the subjects were exposed to a cold environment. In a retrospective study of 5,907 cases of cancer patients (Caucasian), Ozguven et al [11] showed that 25 subjects were aBAT-positive with a positive rate of 0.4 %. Based on the 1:3 ratio between the number of subjects in aBAT-positive group and that in the control group, the study showed that blood TC and LDL-C in the aBAT-positive group were significantly lower than that in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the previous studies used experimental animals or patients with tumors to investigate the effect of aBAT on lipid metabolism [9–11]. These studies showed that aBAT plays an important role in clearing the triglyceride in the blood.…”

Section: Introductionmentioning

confidence: 99%

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The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults

et al. 2016

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BackgroundThe prevalence of dyslipidemia in China was increased over the last several years. Studies have shown that the activity of aBAT is related to the lipid metabolism. In this study, we analyzed blood lipid level in tumor-free healthy Chinese adults in order to determine the role of aBAT in lipid metabolism.MethodsWe retrospectively analyzed the factors that affect the blood lipid level in 717 tumor-free healthy adults who received blood lipid measurement and PET/CT scan by multivariate regression analysis. We also determined the role of aBAT on lipid profile by case–control study.Results(1) Our results showed that 411 (57.3 %) subjects had dyslipidemia. The prevalence of the subjects with hypercholesteremia, hypertriglyceridemia, low high-density lipoprotein cholesterol and high low-density lipoprotein cholesterol was 9.5 %, 44.4 %, 30.8 % and 1.4 %, respectively. Multivariate logistic regression analysis with dyslipidemia as the dependent variable showed that body mass index (BMI) and smoking are independent risk factors for dyslipidemia (OR > 1, P < 0.05), while the presence of aBAT is the independent protective factor for dyslipidemia (OR < 1, P < 0.05). (2) The incidence of aBAT was 1.81 %. Subjects with aBAT had significantly lower serum triglyceride and higher serum high-density lipoprotein cholesterol than the subjects without aBAT. The serum total cholesterol and low-density lipoprotein cholesterol were not significantly different between the subjects with aBAT and those without aBAT.ConclusionsDyslipidemia is caused by multiple factors and the presence of aBAT is a protective factor for dyslipidemia in healthy Chinese adults.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults

et al. 2016

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“…In line with this notion, activation of BAT and beige fat protects against NAFLD in mice, whereas inhibition of BAT and beige fat has the opposite effect (99, 114, 195, 219, 281). Notably, BAT activity is associated with reduced risk for NAFLD (233, 353), suggesting that BAT activation similarly protects against NAFLD in humans. Furthermore, BAT volumes correlate with cold-stimulated lipolysis and FFA oxidation in humans (47), supporting the notion that human BAT and beige fat are also important consumers of circulating FFAs.…”

Section: Brown and Beige Fat Dysfunction In Metabolic Diseasesmentioning

confidence: 99%

Brown and Beige Adipose Tissues in Health and Disease

Rui

2017

Comprehensive Physiology

142

113

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Brown and beige adipocytes arise from distinct developmental origins. Brown adipose tissue (BAT) develops embryonically from precursors that also give to skeletal muscle. Beige fat develops postnatally and is highly inducible. Beige fat recruitment is mediated by multiple mechanisms, including de novo beige adipogenesis and white-to-brown adipocyte transdifferentiaiton. Beige precursors reside around vasculatures, and proliferate and differentiate into beige adipocytes. PDGFRα+Ebf2+ precursors are restricted to beige lineage cells, while another PDGFRα+ subset gives rise to beige adipocytes, white adipocytes, or fibrogenic cells. White adipocytes can be reprogramed and transdifferentiated into beige adipocytes. Brown and beige adipocytes display many similar properties, including multilocular lipid droplets, dense mitochondria, and expression of UCP1. UCP1-mediated thermogenesis is a hallmark of brown/beige adipocytes, albeit UCP1-independent thermogenesis also occurs. Development, maintenance, and activation of BAT/beige fat are guided by genetic and epigenetic programs. Numerous transcriptional factors and coactivators act coordinately to promote BAT/beige fat thermogenesis. Epigenetic reprograming also influences expression of brown/beige adipocyte-selective genes. BAT/beige fat is regulated by neuronal, hormonal, and immune mechanisms. Hypothalamic thermal circuits define the temperature setpoint that guides BAT/beige fat activity. Metabolic hormones, paracrine/autocrine factors, and various immune cells also play a critical role in regulating BAT/beige fat functions. BAT and beige fat defend temperature homeostasis, and regulate body weight and glucose and lipid metabolism. Obesity is associated with brown/beige fat deficiency, and reactivation of brown/beige fat provides metabolic health benefits in some patients. Pharmacological activation of BAT/beige fat may hold promise for combating metabolic diseases.

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“…Recent studies using FDG-PET/CT have revealed that BAT is involved in adaptive energy expenditure, thereby contributing to the regulation of body fat. 5,6 Moreover, BAT is also suggested to participate in glucose homeostasis [7][8][9][10] and to improve blood lipid profiles 11 in humans. Thus, BAT is expected to be a therapeutic target for obesity and related metabolic disorders in humans.…”

Section: Introductionmentioning

confidence: 99%

Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy

et al. 2016

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"Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy," J. Biomed. Opt. 21(9), 091305 (2016), doi: 10.1117/1.JBO.21.9.091305. Abstract.18 F-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is widely used as a standard method for evaluating human brown adipose tissue (BAT), a recognized therapeutic target of obesity. However, a longitudinal BAT study using FDG-PET/CT is lacking owing to limitations of the method. Near-infrared time-resolved spectroscopy (NIR TRS ) is a technique for evaluating human BAT density noninvasively. This study aimed to test whether NIR TRS could detect changes in BAT density during or after long-term intervention. First, using FDG-PET/CT, we confirmed a significant increase (þ48.8%, P < 0.05) in BAT activity in the supraclavicular region after 6-week treatment with thermogenic capsaicin analogs, capsinoids. Next, 20 volunteers were administered either capsinoids or placebo daily for 8 weeks in a double-blind design, and BAT density was measured using NIR TRS every 2 weeks during the 8-week treatment period and an 8-week period after stopping treatment. Consistent with FDG-PET/CT results, NIR TRS successfully detected an increase in BAT density during the 8-week treatment (þ46.4%, P < 0.05), and a decrease in the 8-week follow-up period (−12.5%, P ¼ 0.07), only in the capsinoid-treated, but not the placebo, group. Thus, NIR TRS can be applied for quantitative assessment of BAT in longitudinal intervention studies in humans. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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The role of active brown adipose tissue in human metabolism

Cited by 24 publications

References 25 publications

The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults

The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults

Brown and Beige Adipose Tissues in Health and Disease

Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy

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