The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults

Shao, Xiaoliang; Wei, Yang; Shao, Xiaonan; Qiu, Chao; Wang, Xiaosong; Wang, Yuetao

doi:10.1186/s12944-016-0310-8

Cited by 9 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The potential explanation may be that increased total energy and fat intake in humans was associated with spicy food intake. The type of dyslipidaemia (mainly hypertriacylglycerolaemia and low HDL-cholesterol) in Chinese adults is different from those in Western countries (mainly hypercholesteraemia and high LDL-cholesterol) ( 3 , 4 ) , probably because of low dietary fat and cholesterol intake and high carbohydrate intake in Chinese adults ( 4 ) . In contrast with meat being part of the staple food in a typical Western diet, plain and tasteless rice- or flour-based foods are staples for the Chinese population ( 55 ) .…”

Section: Discussionmentioning

confidence: 99%

“…Dyslipidaemia is one of the major risk factors in the pathogenesis of CVD ( 2 ) , often including hypercholesteraemia, hypertriacylglycerolaemia, high LDL-cholesterol and low HDL-cholesterol. Different from those in the USA and Europe, the main types of dyslipidaemia in Asian countries including China manifest as hypertriacylglycerolaemia and low HDL-cholesterol ( 3 , 4 ) . A report of the China National Diabetes and Metabolic Disorders Study from 2007–2008 estimated that 9·0 % (88·1 million) of Chinese adults had high total cholesterol (TC), 6·5 % (62·8 million) had high LDL-cholesterol and 22·3 % (214·9 million) had low HDL-cholesterol ( 5 ) .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Association between spicy food consumption and lipid profiles in adults: a nationwide population-based study

Xue

et al. 2017

Br J Nutr

View full text Add to dashboard Cite

CVD remains the leading cause of mortality worldwide, with abnormal lipid metabolism as a major risk factor. The aim of this study was to investigate associations between spicy food consumption and serum lipids in Chinese adults. Data were extracted from the 2009 phase of the China Health and Nutrition Survey, consisting of 6774 apparently healthy Chinese adults aged 18-65 years. The frequency of consumption and degree of pungency of spicy food were self-reported, and regular spicy food consumption was assessed using three consecutive 24-h recalls. Total cholesterol, TAG, LDL-cholesterol and HDL-cholesterol in fasting serum were measured. Multilevel mixed-effects models were constructed to estimate associations between spicy food consumption and serum lipid profiles. The results showed that the frequency and the average amount of spicy food intake were both inversely associated with LDL-cholesterol and LDL-cholesterol:HDL-cholesterol ratio (all P for trend<0·05) after adjustment for potential confounders and cluster effects. HDL-cholesterol in participants who usually consumed spicy food (≥5 times/week) and who consumed spicy food perceived as moderate in pungency were significantly higher than those who did not (both P<0·01). The frequency and the average amount of spicy food intake and the degree of pungency in spicy food were positively associated with TAG (all P for trend<0·05). Spicy food consumption was inversely associated with serum cholesterol and positively associated with serum TAG, and additional studies are needed to confirm the findings as well as to elucidate the potential roles of spicy food consumption in lipid metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Association between spicy food consumption and lipid profiles in adults: a nationwide population-based study

Xue

et al. 2017

Br J Nutr

View full text Add to dashboard Cite

show abstract

“…Thus, in rodents, metabolically active BAT exerts significant impact on circulating TRL metabolism. Lower plasma TG and increased HDL-c has been observed in subjects with metabolically active BAT determined by 18 FDG PET/CT ( 148 ). Experimental acute cold exposure in humans does not however lead to significant reduction in plasma TG levels ( 108 , 109 ) and may even lead to small increase in TG and cholesterol levels in some instances ( 106 , 141 ).…”

Section: Energy Substrates Utilization By Batmentioning

confidence: 99%

Brown Adipose Tissue Energy Metabolism in Humans

et al. 2018

View full text Add to dashboard Cite

The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily using positron emission tomography coupled to computed tomography (PET/CT) with the glucose tracer 18-fluorodeoxyglucose (18FDG) has renewed the interest of the scientific and medical community in the possible role of BAT as a target for the prevention and treatment of obesity and type 2 diabetes (T2D). Here, we offer a comprehensive review of BAT energy metabolism in humans. Considerable advances in methods to measure BAT energy metabolism, including nonesterified fatty acids (NEFA), chylomicron-triglycerides (TG), oxygen, Krebs cycle rate, and intracellular TG have led to very good quantification of energy substrate metabolism per volume of active BAT in vivo. These studies have also shown that intracellular TG are likely the primary energy source of BAT upon activation by cold. Current estimates of BAT's contribution to energy expenditure range at the lower end of what would be potentially clinically relevant if chronically sustained. Yet, 18FDG PET/CT remains the gold-standard defining method to quantify total BAT volume of activity, used to calculate BAT's total energy expenditure. Unfortunately, BAT glucose metabolism better reflects BAT's insulin sensitivity and blood flow. It is now clear that most glucose taken up by BAT does not fuel mitochondrial oxidative metabolism and that BAT glucose uptake can therefore be disconnected from thermogenesis. Furthermore, BAT thermogenesis is efficiently recruited upon repeated cold exposure, doubling to tripling its total oxidative capacity, with reciprocal reduction of muscle thermogenesis. Recent data suggest that total BAT volume may be much larger than the typically observed 50–150 ml with 18FDG PET/CT. Therefore, the current estimates of total BAT thermogenesis, largely relying on total BAT volume using 18FDG PET/CT, may underestimate the true contribution of BAT to total energy expenditure. Quantification of the contribution of BAT to energy expenditure begs for the development of more integrated whole body in vivo methods.

show abstract

“…Importantly, diet and lifestyle factors are associated with the development of CKD and some of those factors are population-specific. Indeed, dyslipidemia among Chinese individuals is mainly manifested as high triglycerides and low HDL-C [23–25], and this pattern has been associated, among other factors, with the high consumption of peppers [26]. Previous studies from Japan showed that high triglyceride and low HDL-C levels were associated with declining eGFR [27–29].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, since CKD is related to environmental factors such as diet, stress, and population [21,22], population-specific studies are necessary to identify the factors adequately. The main manifestation of dyslipidemia in China is high triglycerides and low high-density lipoprotein cholesterol (HDL-C) levels [23–25]. The Chinese diet has been associated with high blood triglycerides levels [26].…”

Section: Introductionmentioning

confidence: 99%

Serum Triglycerides Are Related to Chronic Kidney Disease (CKD) Stage 2 in Young and Middle-Aged Chinese Individuals During Routine Health Examination

et al. 2019

View full text Add to dashboard Cite

Background The aim of this study was to determine the risk factors for early chronic kidney disease (CKD) (GFR 60–89 ml/min/1.73 m 2 ; CKD stage 2) in asymptomatic Chinese individuals undergoing routine health examination. Material/Methods This cross-sectional study enrolled 9100 individuals who received voluntary medical examinations between 10/01/2011 and 09/30/2017. Demographic data, clinical history, clinical examination, medication, smoking, alcohol, blood biochemistry, urinalysis, and carotid ultrasound were extracted from the medical records. All laboratory analyses were performed routinely. Multivariable logistic regression for factors predicting CKD stage 2 was performed. Result A total of 9100 individuals were enrolled (age of 18–65 and 65.4% male). CKD stage 2 was found in 1989/9100 individuals (21.9%). Male gender (OR=6.711, 95%CI: 5.376–8.403, P<0.001), older age (OR=1.077, 95%CI: 1.068–1.086, P<0.001), hemoglobin levels (OR=1.051, 95%CI: 1.046–1.057, P<0.001), triglycerides levels (OR=1.174, 95%CI: 1.067–1.292, P=0.001), HDL-C (OR=0.539, 95%CI: 0.380–0.763, P<0.001), Lp(a) levels (OR=1.000, 95%CI: 1.000–1.001, P=0.03), and carotid atherosclerosis (OR=1.248, 95%CI: 1.005–1.550, P=0.045) were associated with CKD stage 2 among all subjects. Serum triglycerides levels were associated with CKD stage 2 in the 18–45 and 45–65 years of age subgroups. Conclusions Factors that are routinely assessed during routine health examinations (male gender, age, hemoglobin levels, triglycerides levels, HDL-C, Lp(a) levels, and carotid atherosclerosis) can help identify individuals at higher risk of having CKD stage 2. The Chinese dyslipidemia is characterized by high triglycerides and low HDL-C and occurs in young and middle-aged individuals. Those factors could help identify individuals at higher risk for CKD stage 2 and who could benefit from preventive treatments.

show abstract

The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults

Cited by 9 publications

References 24 publications

Association between spicy food consumption and lipid profiles in adults: a nationwide population-based study

Association between spicy food consumption and lipid profiles in adults: a nationwide population-based study

Brown Adipose Tissue Energy Metabolism in Humans

Serum Triglycerides Are Related to Chronic Kidney Disease (CKD) Stage 2 in Young and Middle-Aged Chinese Individuals During Routine Health Examination

Contact Info

Product

Resources

About