The role of a dairy fraction rich in milk fat globule membrane in the suppression of postprandial inflammatory markers and bone turnover in obese and overweight adults: an exploratory study

Abstract

BackgroundInflammation is associated with increased bone resorption; the role of inflammation in postprandial bone turnover has not been explored. Consumption of milk fat globule membrane (MFGM) reduces inflammation in animal models. This study aimed to measure postprandial changes in bone turnover after intake of high saturated fat test meals, with- and without the anti-inflammatory ingredient MFGM.MethodsSubjects (n = 36 adults) were obese (BMI 30–39.9 kg/m2) or overweight (BMI 25–29.9 kg/m2) with two traits of Metabolic Syndrome. Subjects consumed a different test meal on four occasions at random; blood draws were taken at baseline and 1, 3, and 6 h postprandial. Test meals included whipping cream (WC), WC + MFGM, palm oil (PO) and PO + MFGM. Biomarkers of bone turnover and inflammation were analyzed from all four time points.ResultsTest meal (treatment) by time interactions were significant for bone resorption marker C-telopeptide of type 1 collagen (CTX) (p < 0.0001) and inflammatory marker interleukin 10 (IL-10) (p = 0.012). Significant differences in overall postprandial response among test meals were found for CTX and soluble intercellular adhesion molecule (sICAM), with the greatest overall postprandial suppression of CTX occurring in meals containing MFGM. However, test meal by MFGM interactions were non- significant for bone and inflammatory markers. Correlations between CTX and inflammatory markers were non-significant.ConclusionThis exploratory analysis advances the study of postprandial suppression of bone turnover by demonstrating differing effects of high SFA meals that contained MFGM; however MFGM alone did not directly moderate the difference in postprandial CTX response among test meals in this analysis. These observations may be useful for identifying foods and ingredients which maximize the suppression of bone resorption, and for generating hypotheses to test in future studies examining the role of inflammation in postprandial bone turnover.Trial registrationClinicaltrials.gov NCT01811329. Registered 11 March 2013.Electronic supplementary materialThe online version of this article (doi:10.1186/s12986-017-0189-z) contains supplementary material, which is available to authorized users.

Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study

“…Dairy fats comprise predominantly SFAs of varying carbon chain lengths with divergent effects on various blood lipids, glucose-insulin homeostasis, and insulin resistance (1,41), which may partially explain neutral associations. In addition, emerging evidence from randomized controlled trials suggests the differential effects of dairy foods on plasma lipids might be influenced by the presence of milk-fat globule membrane, a tri-layered membrane rich in bioactive phospholipids and proteins enclosing the milk fat (42)(43)(44). Consistent with these divergent and complex physiologic effects, our results suggest that overall dairy fat consumption later in life does not significantly influence total mortality but may have associations with specific outcomes.…”

Addition of milk fat globule membrane-enriched supplement to a high-fat meal attenuates insulin secretion and induction of soluble epoxide hydrolase gene expression in the postprandial state in overweight and obese subjects

“…The test meals on both study visit days included either a WC or WC+MFGM smoothie, along with a thin slice of bagel with strawberry preserves. The smoothie contained deionised water, whey protein isolate, raspberry sorbet and anhydrous cream composed of 99·8 % dairy fat ( 33 ) . The WC+MFGM smoothie contained the ingredients previously mentioned, as well as 10 % by weight BPC50, a proprietary cream-derived complex milk lipid fraction powder ( β serum concentrate) supplied by the Fonterra Co-operative Group Ltd (New Zealand).…”

Dietary and Endogenous Sphingolipid Metabolism in Chronic Inflammation

“…IL-10 is an anti-inflammatory cytokine while sICAM is a biomarker positively associated with inflammation [ 178 ]. A pilot study comparing four isocaloric smoothies containing whipping cream or palm oil, made with and without MFGM, found modest effects on the postprandial response when MFGM was fed to obese adults [ 179 ]. The area under the curve for serum sICAM after consuming the palm oil-based smoothie was reduced with added MFGM, although there were no other significant effects on inflammatory markers.…”